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Ciao1 Gene Detail
Summary
  • Symbol
    Ciao1
  • Name
    cytosolic iron-sulfur protein assembly 1
  • Synonyms
    Wdr39
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346998
    NCBI Gene: 26371
  • Gene Overview
    MyGene.info: CIAO1
Location & Maps
more
  • Sequence Map
    Chr2:127240938-127247816 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6879 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 61.86 cM, cytoband F3
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    CIAO1, cytosolic iron-sulfur assembly component 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CIAO1, cytosolic iron-sulfur assembly component 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CIA1, WDR39
  • Links
    NCBI Gene ID: 9391
    neXtProt AC: NX_O76071

  • Chr Location
    2q11.2; chr2:96266146-96274179 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 55850
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: CIAO1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Ciao1
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016012 VEGA Gene Model | MGI Sequence Detail 6879 C57BL/6J ±  kb
transcript OTTMUST00000038151 VEGA | MGI Sequence Detail 3075 Not Applicable  
polypeptide OTTMUSP00000017107 VEGA | MGI Sequence Detail 339 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    116 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000005488 protein CIAO1
  • InterPro Domains
    IPR020472 G-protein beta WD-40 repeat
    IPR028608 Probable cytosolic iron-sulfur protein assembly protein, CIAO1/Cia1
    IPR001680 WD40 repeat
    IPR019775 WD40 repeat, conserved site
    IPR017986 WD40-repeat-containing domain
    IPR015943 WD40/YVTN repeat-like-containing domain
Molecular
Reagents
less
  • All nucleic 19
    cDNA 19

    Microarray probesets 6
Other
Accession IDs
less
MGI:2139326
References
more
  • Summaries
    All 39
    Developmental Gene Expression 6
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:71342 Johnstone RW, et al., Ciao 1 is a novel WD40 protein that interacts with the tumor suppressor protein WT1. J Biol Chem. 1998 May 1;273(18):10880-7
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory