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Map3k12 Gene Detail
Summary
  • Symbol
    Map3k12
  • Name
    mitogen-activated protein kinase kinase kinase 12
  • Synonyms
    DLK, MUK, Zpk
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346881
    NCBI Gene: 26404
  • Gene Overview
    MyGene.info: MAP3K12
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:102497649-102517064 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19416 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 57.63 cM, cytoband F3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MAP3K12, mitogen-activated protein kinase kinase kinase 12
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MAP3K12, mitogen-activated protein kinase kinase kinase 12
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DLK, MEKK12, MUK, ZPK, ZPKP1
  • Links
    NCBI Gene ID: 7786
    neXtProt AC: NX_Q12852
    UniProt: Q12852

  • Chr Location
    12q13.13; chr12:53480492-53501066 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 6 alleles in 6 genetic backgrounds
    4 phenotypes from multigenic genotypes
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene-trapped allele lack the brain anterior commissure. Mice homozygous for a knock-out allele exhibit postnatal lethality and abnormal axon growth and radial migration of neocortical pyramidal neurons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000036001 VEGA Gene Model | MGI Sequence Detail 19416 C57BL/6J ±  kb
    transcript OTTMUST00000092376 VEGA | MGI Sequence Detail 5182 Not Applicable  
    polypeptide OTTMUSP00000051036 VEGA | MGI Sequence Detail 888 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      48 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000010131 mitogen-activated protein kinase kinase kinase 12
    • EC
    • InterPro Domains
      IPR027257 Mitogen-activated protein kinase kinase kinase 12
      IPR017419 Mitogen-activated protein kinase kinase kinase 12/13
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    Molecular
    Reagents
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    • All nucleic 23
      cDNA 22
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-19592, MGI:102689
    References
    more
    • Summaries
      All 96
      Developmental Gene Expression 17
      Diseases 1
      Gene Ontology 9
      Phenotypes 50
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:255971 Welsbie DS, et al., Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons. Neuron. 2017 Jun 21;94(6):1142-1154.e6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory