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Map3k10 Gene Detail
Summary
  • Symbol
    Map3k10
  • Name
    mitogen-activated protein kinase kinase kinase 10
  • Synonyms
    mixed lineage kinase 2, MKN28 derived nonreceptor_type, MKN28 kinase, Mlk2, serine/threonine kinase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346879
    NCBI Gene: 269881
  • Gene Overview
    MyGene.info: MAP3K10
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:27656375-27674594 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18220 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 15.95 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MAP3K10, mitogen-activated protein kinase kinase kinase 10
  • Vertebrate Orthologs
    7
  • Human Ortholog
    MAP3K10, mitogen-activated protein kinase kinase kinase 10
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MEKK10, MLK2, MST
  • Links
    NCBI Gene ID: 4294
    neXtProt AC: NX_Q02779
    UniProt: Q02779

  • Chr Location
    19q13.2; chr19:40191657-40215575 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit normal development, reproduction and lifespan.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000023963 VEGA Gene Model | MGI Sequence Detail 18220 C57BL/6J ±  kb
    transcript OTTMUST00000058564 VEGA | MGI Sequence Detail 3682 Not Applicable  
    polypeptide OTTMUSP00000028391 VEGA | MGI Sequence Detail 940 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      69 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • EC
    • InterPro Domains
      IPR015785 Mitogen-activated protein (MAP) kinase kinase kinase 10
      IPR016231 Mitogen-activated protein (MAP) kinase kinase kinase, MLK1-4
      IPR035779 MLK1-3, SH3 domain
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR001452 SH3 domain
      IPR036028 SH3-like domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1336178, MGI:2652863, MGI:2652864
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:51605 Phelan DR, et al., Expression of mixed lineage kinase 2 in germ cells of the testis. Mol Reprod Dev. 1999 Feb;52(2):135-40
    • Latest
      J:261382 Kant S, et al., A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress. Cell Rep. 2017 Sep 19;20(12):2775-2783

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory