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Map3k8
Gene Detail
 Symbol
Name
ID
Map3k8
mitogen-activated protein kinase kinase kinase 8
MGI:1346878
Synonyms c-COT, Cot, Cot/Tpl2, Tpl2, Tpl-2
Feature Type protein coding gene
Genetic Map
Chromosome 18
2.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr18:4331327-4353015 bp, - strand
From VEGA annotation of GRCm38

  21689 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3812  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: mitogen-activated protein kinase kinase kinase 8
Gene Tree: Map3k8

Human
homologs
Human Homolog MAP3K8, mitogen-activated protein kinase kinase kinase 8
NCBI Gene ID 1326
neXtProt AC  NX_P41279
Human Synonyms  c-COT, COT, EST, ESTF, MEKK8, Tpl-2, TPL2
Human Chr (Location)  10p11.23; chr10:30434021-30461833 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human MAP3K8
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(1) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Mutant mice resist endotoxic shock. Their MHC II expression is enhanced. Macrophages' TNF-alpha response to viruses and to all TLR ligands is impaired. Macrophage and T-cell secretion of other cytokines in response to various TLR ligands or OVA is aberrant. Anti-OVA Ig classes are abnormally skewed.
 
Interactions
Map3k8 interacts with 306 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process apoptotic process, cell cycle, ...
Component cytoplasm
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (31)    Tissues (22)   
Theiler Stages: 22, 26, 27, 28
Assay TypeResults
RNA in situ 31
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) Genomic(6) cDNA(24)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037645 (Evidence)
Ensembl Gene ModelENSMUSG00000024235 (Evidence)
Entrez Gene26410 (Evidence)
UniGene3275
DFCITC1581800
DoTSDT.101221331, DT.101367394, DT.40185010
NIA Mouse Gene IndexU130018
EC2.7.11.25
Consensus CDS ProjectCCDS29036.1
International Mouse Knockout Project StatusMap3k8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037645 VEGA Gene Model | MGI Sequence Detail 21689 C57BL/6J ±  kb
transcript OTTMUST00000097151 VEGA | MGI Sequence Detail 2507 Not Applicable 
polypeptide OTTMUSP00000054423 VEGA | MGI Sequence Detail 467 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(6) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(81 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017424 Mitogen-activated protein (MAP) kinase kinase kinase 8
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000010140 mitogen-activated protein kinase kinase kinase 8
References (Earliest) J:1701 Justice MJ, et al., A molecular genetic linkage map of mouse chromosome 18 reveals extensive linkage conservation with human chromosomes 5 and 18. Genomics. 1992 Aug;13(4):1281-8
(Latest) J:211623 Ben-Addi A, et al., IkappaB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinases. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):E2394-403
All references(86)
Other
accession IDs
MGD-MRK-15201, MGD-MRK-2095, MGI:88472, MGI:98808

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory