Map3k8
Gene Detail

Symbol Name ID

Map3k8 mitogen-activated protein kinase kinase kinase 8 MGI:1346878

Synonyms

c-COT, Cot, Cot/Tpl2, Tpl2, Tpl-2

Feature Type

protein coding gene

Genetic Map

Chromosome 18

2.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr18:4331327-4353015 bp, - strand From VEGA annotation of GRCm38   21689 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3812  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: mitogen-activated protein kinase kinase kinase 8
Gene Tree: Map3k8

Human homologs

Human Homolog		MAP3K8, mitogen-activated protein kinase kinase kinase 8
NCBI Gene ID		1326
neXtProt AC		NX_P41279
Human Synonyms		c-COT, COT, EST, ESTF, MEKK8, Tpl-2, TPL2
Human Chr (Location)		10p11.23; chr10:30722950-30750762 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MAP3K8

Alleles and phenotypes

All alleles(9) : Targeted(8) Chemically induced(1)
 

Mutant mice resist endotoxic shock. Their MHC II expression is enhanced. Macrophages' TNF-alpha response to viruses and to all TLR ligands is impaired. Macrophage and T-cell secretion of other cytokines in response to various TLR ligands or OVA is aberrant. Anti-OVA Ig classes are abnormally skewed.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	cell cycle, phosphorylation, ...
Component	cytoplasm
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (31)    Tissues (19)   
Theiler Stages: 22, 26, 28

Assay Type	Results
RNA in situ	31

cDNA source data(23)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(30) Genomic(6) cDNA(24)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000037645 (Evidence)
Ensembl Gene Model	ENSMUSG00000024235 (Evidence)
Entrez Gene	26410 (Evidence)
UniGene	3275
DFCI	TC1581800
DoTS	DT.101221331, DT.101367394, DT.40185010
NIA Mouse Gene Index	U130018
EC	2.7.11.25
Consensus CDS Project	CCDS29036.1
International Mouse Knockout Project Status	Map3k8

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037645	VEGA Gene Model | MGI Sequence Detail	21689	C57BL/6J
transcript	OTTMUST00000097151	VEGA | MGI Sequence Detail	2507	Not Applicable
polypeptide	OTTMUSP00000054423	VEGA | MGI Sequence Detail	467	Not Applicable

All sequences(38) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(1) : SNPs(81 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017424	Mitogen-activated protein (MAP) kinase kinase kinase 8
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000010140	mitogen-activated protein kinase kinase kinase 8

References

(Earliest) J:1701 Justice MJ, et al., A molecular genetic linkage map of mouse chromosome 18 reveals extensive linkage conservation with human chromosomes 5 and 18. Genomics. 1992 Aug;13(4):1281-8
(Latest) J:193546 Koliaraki V, et al., Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis. J Clin Invest. 2012 Nov 1;122(11):4231-42
All references(73)

Other accession IDs

MGD-MRK-15201, MGD-MRK-2095, MGI:88472, MGI:98808