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Map3k8
Gene Detail
Symbol

Name
ID
Map3k8
mitogen-activated protein kinase kinase kinase 8
MGI:1346878
Synonyms
c-COT, Cot, Cot/Tpl2, Tpl2, Tpl-2
Feature Type
protein coding gene
Genetic Map
Chromosome 18
2.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr18:4331327-4353015 bp, - strand
From VEGA annotation of GRCm38

  21689 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3812  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MAP3K8
Protein SuperFamily: mitogen-activated protein kinase kinase kinase 8
Gene Tree: Map3k8

Human
homologs
MAP3K8, mitogen-activated protein kinase kinase kinase 8
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1326
neXtProt AC: NX_P41279

Human Synonyms: AURA2, c-COT, COT, EST, ESTF, MEKK8, Tpl-2, TPL2

Human Chr (Location): 10p11.23; chr10:30434003-30461833 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MAP3K8

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Chemically induced (ENU)(2) Targeted(11)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mutant mice resist endotoxic shock. Their MHC II expression is enhanced. Macrophages' TNF-alpha response to viruses and to all TLR ligands is impaired. Macrophage and T-cell secretion of other cytokines in response to various TLR ligands or OVA is aberrant. Anti-OVA Ig classes are abnormally skewed.
 
Interactions
Map3k8 interacts with 305 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process activation of protein kinase activity, cell cycle, ...
Component cytoplasm
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (31)    Tissues (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 31
cDNA source data(23)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase map3k8    NEW 
Molecular
reagents
All nucleic(30) Genomic(6) cDNA(24)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000037645 (Evidence)
Ensembl Gene Model ENSMUSG00000024235 (Evidence)
Entrez Gene 26410 (Evidence)
UniGene 3275
DFCI TC1581800
DoTS DT.101221331, DT.101367394, DT.40185010
NIA Mouse Gene Index U130018
EC 2.7.11.25
Consensus CDS Project CCDS29036.1
International Mouse Phenotyping Consortium Status Map3k8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037645 VEGA Gene Model | MGI Sequence Detail 21689 C57BL/6J ±  kb
transcript OTTMUST00000097151 VEGA | MGI Sequence Detail 2507 Not Applicable 
polypeptide OTTMUSP00000054423 VEGA | MGI Sequence Detail 467 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(6) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(81 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017424 Mitogen-activated protein (MAP) kinase kinase kinase 8
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000010140 mitogen-activated protein kinase kinase kinase 8
References
(Earliest) J:1701 Justice MJ, et al., A molecular genetic linkage map of mouse chromosome 18 reveals extensive linkage conservation with human chromosomes 5 and 18. Genomics. 1992 Aug;13(4):1281-8
(Latest) J:214726 Xiao Y, et al., TPL2 mediates autoimmune inflammation through activation of the TAK1 axis of IL-17 signaling. J Exp Med. 2014 Jul 28;211(8):1689-702
All references(91)
Other
accession IDs
MGD-MRK-15201, MGD-MRK-2095, MGI:88472, MGI:98808

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory