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Map3k8 Gene Detail
Summary
  • Symbol
    Map3k8
  • Name
    mitogen-activated protein kinase kinase kinase 8
  • Synonyms
    c-COT, Cot, Cot/Tpl2, Tpl2, Tpl-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346878
    NCBI Gene: 26410
Location & Maps
more
  • Sequence Map
    Chr18:4331327-4353015 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21689 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MAP3K8, mitogen-activated protein kinase kinase kinase 8
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MAP3K8, mitogen-activated protein kinase kinase kinase 8
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AURA2, c-COT, COT, EST, ESTF, MEKK8, Tpl-2, TPL2
  • Links
    NCBI Gene ID: 1326
    neXtProt AC: NX_P41279

  • Chr Location
    10p11.23; chr10:30434003-30461833 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human MAP3K8 associations

Human Disease Mouse Models
       Lung Cancer   OMIM: 211980
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 9 alleles in 12 genetic backgrounds
    6 phenotypes from multigenic genotypes
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (ENU)
    3
  • Targeted
    11
  • Transgenic
    1
  • Incidental Mutations
Mutant mice resist endotoxic shock. Their MHC II expression is enhanced. Macrophages' TNF-alpha response to viruses and to all TLR ligands is impaired. Macrophage and T-cell secretion of other cytokines in response to various TLR ligands or OVA is aberrant. Anti-OVA Ig classes are abnormally skewed.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037645 VEGA Gene Model | MGI Sequence Detail 21689 C57BL/6J ±  kb
transcript OTTMUST00000097151 VEGA | MGI Sequence Detail 2507 Not Applicable  
polypeptide OTTMUSP00000054423 VEGA | MGI Sequence Detail 467 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    81 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000010140 mitogen-activated protein kinase kinase kinase 8
  • EC
  • InterPro Domains
    IPR017424 Mitogen-activated protein (MAP) kinase kinase kinase 8
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
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  • All nucleic 30
    Genomic 6
    cDNA 24

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-15201, MGD-MRK-2095, MGI:88472, MGI:98808
References
more
  • Summaries
    All 94
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 51
  • Earliest
    J:1701 Justice MJ, et al., A molecular genetic linkage map of mouse chromosome 18 reveals extensive linkage conservation with human chromosomes 5 and 18. Genomics. 1992 Aug;13(4):1281-8
  • Latest
    J:222892 Luo M, et al., Polycomb protein SCML2 associates with USP7 and counteracts histone H2A ubiquitination in the XY chromatin during male meiosis. PLoS Genet. 2015 Jan;11(1):e1004954

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory