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Map3k5 Gene Detail
Summary
  • Symbol
    Map3k5
  • Name
    mitogen-activated protein kinase kinase kinase 5
  • Synonyms
    7420452D20Rik, ASK, ASK1, Mekk5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346876
    NCBI Gene: 26408
  • Gene Overview
    MyGene.info: MAP3K5
Location & Maps
more
  • Sequence Map
    Chr10:19934472-20142753 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      208282 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 9.35 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MAP3K5, mitogen-activated protein kinase kinase kinase 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAP3K5, mitogen-activated protein kinase kinase kinase 5
    Orthology source: HomoloGene
  • Synonyms
    ASK1, MAPKKK5, MEKK5
  • Links
    NCBI Gene ID: 4217
    neXtProt AC: NX_Q99683

  • Chr Location
    6q22.33; chr6:136557046-136793051 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Targeted
    4
  • Genomic Mutations
    1 involving Map3k5
  • Incidental Mutations
Homozygous mutant mice are overtly normal, however apoptosis abnormalities are evident in cultured cells and after induced heart damage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031050 VEGA Gene Model | MGI Sequence Detail 208282 C57BL/6J ±  kb
transcript OTTMUST00000076924 VEGA | MGI Sequence Detail 5450 Not Applicable  
polypeptide OTTMUSP00000040557 VEGA | MGI Sequence Detail 1380 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1082 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000010138 mitogen-activated protein kinase kinase kinase 5
  • EC
  • InterPro Domains
    IPR025136 Domain of unknown function DUF4071
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
    IPR013761 Sterile alpha motif/pointed domain
Molecular
Reagents
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  • All nucleic 36
    cDNA 34
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
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MGI:1101761, MGI:2445207
References
more
  • Summaries
    All 92
    Developmental Gene Expression 11
    Gene Ontology 11
    Phenotypes 47
  • Earliest
    J:44039 Tobiume K, et al., Molecular cloning and characterization of the mouse apoptosis signal-regulating kinase 1. Biochem Biophys Res Commun. 1997 Oct 29;239(3):905-10
  • Latest
    J:226104 Wang F, et al., ASK1 mediates the teratogenicity of diabetes in the developing heart by inducing ER stress and inhibiting critical factors essential for cardiac development. Am J Physiol Endocrinol Metab. 2015 Sep 1;309(5):E487-99

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory