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Map3k5
Gene Detail
Symbol

Name
ID
Map3k5
mitogen-activated protein kinase kinase kinase 5
MGI:1346876
Synonyms
7420452D20Rik, ASK, ASK1, Mekk5
Feature Type
protein coding gene
Genetic Map
Chromosome 10
9.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:19934472-20142753 bp, + strand
From VEGA annotation of GRCm38

  208282 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38114  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: MAPKKK 5-like kinase
Gene Tree: Map3k5

Human
homologs
Human Homolog MAP3K5, mitogen-activated protein kinase kinase kinase 5
NCBI Gene ID 4217
neXtProt AC  NX_Q99683
Human Synonyms  ASK1, MAPKKK5, MEKK5
Human Chr (Location)  6q22.33; chr6:136557040-136793047 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(3) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice are overtly normal, however apoptosis abnormalities are evident in cultured cells and after induced heart damage.
 
Interactions
Map3k5 interacts with 271 markers (Mir1b, Mir7-1, Mir7-2, ...)
Expression
Literature Summary: (10 records)
Data Summary: Results (303)    Tissues (224)    Images (70)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 303
cDNA source data(34)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) cDNA(34) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000031050 (Evidence)
Ensembl Gene ModelENSMUSG00000071369 (Evidence)
Entrez Gene26408 (Evidence)
UniGene6595
DFCITC1586429, TC1598876
DoTSDT.40154559
NIA Mouse Gene IndexU011315
EC2.7.11.25
Consensus CDS ProjectCCDS35857.1
International Mouse Knockout Project StatusMap3k5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031050 VEGA Gene Model | MGI Sequence Detail 208282 C57BL/6J ±  kb
transcript OTTMUST00000076924 VEGA | MGI Sequence Detail 5450 Not Applicable 
polypeptide OTTMUSP00000040557 VEGA | MGI Sequence Detail 1380 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(4) UniProt(6)
Polymorphisms
SNPs within 2kb(1087 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025136 Domain of unknown function DUF4071
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR013761 Sterile alpha motif/pointed domain
Protein Ontology PR:000010138 mitogen-activated protein kinase kinase kinase 5
References
(Earliest) J:44039 Tobiume K, et al., Molecular cloning and characterization of the mouse apoptosis signal-regulating kinase 1. Biochem Biophys Res Commun. 1997 Oct 29;239(3):905-10
(Latest) J:206462 Noguchi H, et al., Depletion of apoptosis signal-regulating kinase 1 prevents bile duct ligation-induced necroinflammation and subsequent peribiliary fibrosis. Am J Pathol. 2014 Mar;184(3):644-61
All references(86)
Other
accession IDs
MGI:1101761, MGI:2445207

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory