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Map3k4 Gene Detail
Summary
  • Symbol
    Map3k4
  • Name
    mitogen-activated protein kinase kinase kinase 4
  • Synonyms
    D17Rp17, D17Rp17e, MAPKKK4, Mekk4, mKIAA0213, MTK1, RP17, Tas
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346875
    NCBI Gene: 26407
  • Gene Overview
    MyGene.info: MAP3K4
Location & Maps
more
  • Sequence Map
    Chr17:12227621-12318660 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      91040 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 8.42 cM
  • Mapping Data
    45 experiments
Homology
more
  • Human Ortholog
    MAP3K4, mitogen-activated protein kinase kinase kinase 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAP3K4, mitogen-activated protein kinase kinase kinase 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MAPKKK4, MEKK4, MEKK 4, MTK1, PRO0412
  • Links
    NCBI Gene ID: 4216
    neXtProt AC: NX_Q9Y6R4

  • Chr Location
    6q26; chr6:160991727-161117385 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 3 alleles in 4 genetic backgrounds
    12 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (ENU)
    1
  • Gene trapped
    4
  • Not Applicable
    1
  • Targeted
    5
  • Transgenic
    1
  • Genomic Mutations
    1 involving Map3k4
  • Incidental Mutations
Homozygous null mice exhibit some perinatal lethality and survivors appear smaller. On certain genetic backgrounds, heterozygous X/Y mice may develop as phenotypic females or hermaphrodites. The sex-reversal phenotype is dependent on a combination of strain-specific autosomal and Y-linked alleles.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000014426 Ensembl Gene Model | MGI Sequence Detail 91040 C57BL/6J ±  kb
transcript ENSMUST00000089058 Ensembl | MGI Sequence Detail 5305 Not Applicable  
polypeptide ENSMUSP00000086459 Ensembl | MGI Sequence Detail 1597 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    623 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000010137 mitogen-activated protein kinase kinase kinase 4
  • EC
  • InterPro Domains
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
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  • All nucleic 109
    Genomic 6
    cDNA 101
    Primer pair 1
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-14016, MGD-MRK-14718, MGD-MRK-39591, MGD-MRK-4772, MGD-MRK-4773, MGI:109592, MGI:90953, MGI:98486
References
more
  • Summaries
    All 83
    Developmental Gene Expression 10
    Gene Ontology 9
    Phenotypes 23
  • Earliest
    J:85320 Dickie MM, et al., Hairpin tail, Hp. Mouse News Lett. 1965;32:43-44
  • Latest
    J:231463 Haque K, et al., MEKK4 Signaling Regulates Sensory Cell Development and Function in the Mouse Inner Ear. J Neurosci. 2016 Jan 27;36(4):1347-61

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory