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Map2k6
Gene Detail
Symbol

Name
ID
Map2k6
mitogen-activated protein kinase kinase 6
MGI:1346870
Synonyms
MAP kinase kinase 6, MKK6, Prkmk6, SAPKK3
Feature Type
protein coding gene
Genetic Map
Chromosome 11
73.60 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:110399122-110525522 bp, + strand
From VEGA annotation of GRCm38

  126401 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55686  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MAP2K6
Protein SuperFamily: kinase-related transforming protein
Gene Tree: Map2k6

Human
homologs
MAP2K6, mitogen-activated protein kinase kinase 6
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5608
neXtProt AC: NX_P52564

Human Synonyms: MAPKK6, MEK6, MKK6, PRKMK6, SAPKK3, SAPKK-3

Human Chr (Location): 17q24.3; chr17:69414697-69542329 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(17) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for null targeted mutations of this gene are viable, grow normally and have no gross physical or histologic abnormalities.
 
Interactions
Map2k6 interacts with 99 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process activation of MAPK activity, apoptotic process, ...
Component cytoplasm, cytoskeleton, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (177)    Tissues (166)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 117
RT-PCR 54
cDNA source data(40)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase map2k6 ; ZFIN map2k6    NEW 
Molecular
reagents
All nucleic(46) cDNA(42) Primer pair(4)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000003325 (Evidence)
Ensembl Gene Model ENSMUSG00000020623 (Evidence)
Entrez Gene 26399 (Evidence)
UniGene 14487
DFCI TC1579040, TC1657773, TC1681539
DoTS DT.101157308, DT.101381353, DT.480701, DT.91393199, DT.97410803
NIA Mouse Gene Index U013503
EC 2.7.12.2
Consensus CDS Project CCDS25592.1
International Mouse Phenotyping Consortium Status Map2k6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003325 VEGA Gene Model | MGI Sequence Detail 126401 C57BL/6J ±  kb
transcript OTTMUST00000006983 VEGA | MGI Sequence Detail 2068 Not Applicable 
polypeptide OTTMUSP00000003317 VEGA | MGI Sequence Detail 334 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(14) UniProt(7)
Polymorphisms
SNPs within 2kb(652 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000003282 dual specificity mitogen-activated protein kinase kinase 6
References
(Earliest) J:36237 Han J, et al., Characterization of the structure and function of a novel MAP kinase kinase (MKK6). J Biol Chem. 1996 Feb 9;271(6):2886-91
(Latest) J:218387 Greenblatt MB, et al., p38alpha MAPK is required for tooth morphogenesis and enamel secretion. J Biol Chem. 2015 Jan 2;290(1):284-95
All references(65)
Other
accession IDs
MGD-MRK-37068, MGI:108032

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory