Map2k6
Gene Detail

Symbol Name ID

Map2k6 mitogen-activated protein kinase kinase 6 MGI:1346870

Synonyms

MAP kinase kinase 6, MKK6, Prkmk6, SAPKK3

Feature Type

protein coding gene

Genetic Map

Chromosome 11

73.60 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:110399122-110525522 bp, + strand From VEGA annotation of GRCm38   126401 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55686  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Map2k6

Human homologs

Human Homolog		MAP2K6, mitogen-activated protein kinase kinase 6
NCBI Gene ID		5608
neXtProt AC		NX_P52564
Human Synonyms		MAPKK6, MEK6, MKK6, PRKMK6, SAPKK3, SAPKK-3
Human Chr (Location)		17q24.3; chr17:67410838-67538470 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(20) : Targeted(3) Gene trapped(17)
 

Mice homozygous for null targeted mutations of this gene are viable, grow normally and have no gross physical or histologic abnormalities.

 

Gene Ontology (GO) classifications

All GO classifications: (30 annotations)

Process	activation of MAPK activity, apoptotic process, ...
Component	cytoplasm, cytoskeleton, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (164)    Tissues (154)    Images (15)
Theiler Stages: 22, 23, 24, 28

Assay Type	Results
RNA in situ	117
RT-PCR	47

cDNA source data(41)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(46) cDNA(43) Primer pair(3)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000003325 (Evidence)
Ensembl Gene Model	ENSMUSG00000020623 (Evidence)
Entrez Gene	26399 (Evidence)
UniGene	14487
DFCI	TC1579040, TC1657773, TC1681539
DoTS	DT.101157308, DT.101381353, DT.480701, DT.91393199, DT.97410803
NIA Mouse Gene Index	U013503
EC	2.7.12.2
Consensus CDS Project	CCDS25592.1
International Mouse Knockout Project Status	Map2k6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000003325	VEGA Gene Model | MGI Sequence Detail	126401	C57BL/6J
transcript	OTTMUST00000006983	VEGA | MGI Sequence Detail	2068	Not Applicable
polypeptide	OTTMUSP00000003317	VEGA | MGI Sequence Detail	334	Not Applicable

All sequences(48) RefSeq(2) UniProt(7)

Polymorphisms

SNPs(329 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000003282	dual specificity mitogen-activated protein kinase kinase 6

References

(Earliest) J:36237 Han J, et al., Characterization of the structure and function of a novel MAP kinase kinase (MKK6). J Biol Chem. 1996 Feb 9;271(6):2886-91
(Latest) J:194180 Gonzalez-Teran B, et al., Eukaryotic elongation factor 2 controls TNF-alpha translation in LPS-induced hepatitis. J Clin Invest. 2013 Jan 2;123(1):164-78
All references(61)

Other accession IDs

MGD-MRK-37068, MGI:108032