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Map2k2
Gene Detail
Symbol

Name
ID
Map2k2
mitogen-activated protein kinase kinase 2
MGI:1346867
Synonyms
MAP kinase/Erk kinase, MEK2, Prkmk2
Feature Type
protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr10:81105915-81124697 bp, + strand
From VEGA annotation of GRCm38

  18783 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48591  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

HCOP human homology predictions: MAP2K2
Protein SuperFamily: kinase-related transforming protein
Gene Tree: Map2k2

Human
homologs
MAP2K2, mitogen-activated protein kinase kinase 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5605
neXtProt AC: NX_P36507

Human Synonyms: CFC4, MAPKK2, MEK2, MKK2, PRKMK2

Human Chr (Location): 19p13.3; chr19:4090321-4124184 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MAP2K2

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(14) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation are viable, fertile, and apparently normal.
 
Interactions
Map2k2 interacts with 112 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (58 annotations)
Process activation of MAPK activity, epithelial cell proliferation involved in lung morphogenesis, ...
Component cell-cell junction, cell cortex, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (234)    Tissues (192)    Images (48)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 41
RNA in situ 161
Northern blot 10
Western blot 18
RT-PCR 4
cDNA source data(190)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN map2k2a    NEW 
Molecular
reagents
All nucleic(195) cDNA(192) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000016975 (Evidence)
Ensembl Gene Model ENSMUSG00000035027 (Evidence)
Entrez Gene 26396 (Evidence)
UniGene 275436
DFCI TC1572291, TC1626144, TC1647180, TC1756567
DoTS DT.101381227, DT.110605331, DT.94395708, DT.55184980
NIA Mouse Gene Index U011771
EC 2.7.12.2
PDB 1JKY
Consensus CDS Project CCDS24044.1
International Mouse Phenotyping Consortium Status Map2k2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016975 VEGA Gene Model | MGI Sequence Detail 18783 C57BL/6J ±  kb
transcript OTTMUST00000041162 VEGA | MGI Sequence Detail 2405 Not Applicable 
polypeptide OTTMUSP00000018442 VEGA | MGI Sequence Detail 401 Not Applicable 

For the selected sequences
All sequences(89) RefSeq(8) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(24 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000010126 dual specificity mitogen-activated protein kinase kinase 2
References
(Earliest) J:21571 Brott BK, et al., MEK2 is a kinase related to MEK1 and is differentially expressed in murine tissues. Cell Growth Differ. 1993 Nov;4(11):921-9
(Latest) J:219604 Noel A, et al., ERK (MAPK) does not phosphorylate tau under physiological conditions in vivo or in vitro. Neurobiol Aging. 2015 Feb;36(2):901-2
All references(96)
Other
accession IDs
MGD-MRK-18661, MGI:101840, MGI:2143493

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory