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Map2k2 Gene Detail
Summary
  • Symbol
    Map2k2
  • Name
    mitogen-activated protein kinase kinase 2
  • Synonyms
    MAP kinase/Erk kinase, MEK2, Prkmk2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346867
    NCBI Gene: 26396
  • Gene Overview
    MyGene.info: MAP2K2
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:81105912-81124697 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    24 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346867
protein coding gene Chr10:81105912-81133975 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017536
protein coding gene Chr10:81793141-81816680 (+)
A/J MGP_AJ_G0017514
protein coding gene Chr10:78901499-78921387 (+)
AKR/J MGP_AKRJ_G0017475
protein coding gene Chr10:81070472-81093696 (+)
BALB/cJ MGP_BALBcJ_G0017476
protein coding gene Chr10:79116700-79136753 (+)
C3H/HeJ MGP_C3HHeJ_G0017299
protein coding gene Chr10:81154574-81173258 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017930
protein coding gene Chr10:84599281-84618390 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015619
protein coding gene Chr10:75105136-75123458 (+)
CAST/EiJ MGP_CASTEiJ_G0016866
protein coding gene Chr10:81392597-81413053 (+)
CBA/J MGP_CBAJ_G0017271
protein coding gene Chr10:87895035-87920304 (+)
DBA/2J MGP_DBA2J_G0017377
protein coding gene Chr10:78095947-78114723 (+)
FVB/NJ MGP_FVBNJ_G0017371
protein coding gene Chr10:77339016-77360072 (+)
LP/J MGP_LPJ_G0017448
protein coding gene Chr10:82240323-82261401 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017397
protein coding gene Chr10:89763162-89787563 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017971
protein coding gene Chr10:81059479-81080600 (+)
PWK/PhJ MGP_PWKPhJ_G0016647
protein coding gene Chr10:78000265-78019319 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016437
protein coding gene Chr10:80017782-80036936 (+)
WSB/EiJ MGP_WSBEiJ_G0016926
protein coding gene Chr10:81098000-81117412 (+)



Homology
more
  • Human Ortholog
    MAP2K2, mitogen-activated protein kinase kinase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAP2K2, mitogen-activated protein kinase kinase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CFC4, MAPKK2, MEK2, MKK2, PRKMK2
  • Links
    NCBI Gene ID: 5605
    neXtProt AC: NX_P36507
    UniProt: P36507

  • Chr Location
    19p13.3; chr19:4090321-4124184 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human MAP2K2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    25 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation are viable, fertile, and apparently normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26396 NCBI Gene Model | MGI Sequence Detail 18786 C57BL/6J ±  kb
    transcript NM_001358539 RefSeq | MGI Sequence Detail 2548 C57BL/6  
    polypeptide Q63932 UniProt | EBI | MGI Sequence Detail 401 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 196
      cDNA 193
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-18661, MGI:101840, MGI:2143493
    References
    more
    • Summaries
      All 129
      Developmental Gene Expression 30
      Gene Ontology 14
      Phenotypes 39
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:266214 Garg A, et al., FGF-induced Pea3 transcription factors program the genetic landscape for cell fate determination. PLoS Genet. 2018 Sep;14(9):e1007660

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/27/2018
    MGI 6.13
    The Jackson Laboratory