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Mapk13
Gene Detail
 Symbol
Name
ID
Mapk13
mitogen-activated protein kinase 13
MGI:1346864
Synonyms p38 delta MAP kinase, SAPK4, Serk4
Feature Type protein coding gene
Genetic Map
Chromosome 17
15.00 cM, cytoband A3-B
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:28769307-28778698 bp, + strand
From VEGA annotation of GRCm38

  9392 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48133  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Mapk13

Human
homologs
Human Homolog MAPK13, mitogen-activated protein kinase 13
NCBI Gene ID 5603
neXtProt AC  NX_O15264
Human Synonyms  MAPK 13, MAPK-13, p38delta, PRKM13, SAPK4
Human Chr (Location)  6p21.31; chr6:36130484-36144524 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit improved glucose tolerance, increased insulin secretion, decreased blood glucose, and decreased susceptibility to diet- or chemically-induced diabetes.
 
Interactions
Mapk13 interacts with 49 markers (Mir17, Mir20b, Mir103-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cell cycle, intracellular signal transduction, ...
Component intracellular
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (201)    Tissues (34)    Images (27)
Theiler Stages: 19, 23, 24
Assay TypeResults
RNA in situ 201
cDNA source data(49)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(50) cDNA(50)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000024249 (Evidence)
Ensembl Gene ModelENSMUSG00000004864 (Evidence)
Entrez Gene26415 (Evidence)
UniGene27970
DFCITC1581117
DoTSDT.490228, DT.97389875
EC2.7.11.24
Consensus CDS ProjectCCDS28584.1
International Mouse Knockout Project StatusMapk13
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024249 VEGA Gene Model | MGI Sequence Detail 9392 C57BL/6J ±  kb
transcript OTTMUST00000059350 VEGA | MGI Sequence Detail 1392 Not Applicable 
polypeptide OTTMUSP00000028863 VEGA | MGI Sequence Detail 366 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(79 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003527 Mitogen-activated protein (MAP) kinase, conserved site
InterPro IPR008352 Mitogen-activated protein (MAP) kinase, p38
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
Protein Ontology PR:000010154 mitogen-activated protein kinase 13
References (Earliest) J:38682 Foltz IN, et al., Hemopoietic growth factors with the exception of interleukin-4 activate the p38 mitogen-activated protein kinase pathway. J Biol Chem. 1997 Feb 7;272(6):3296-301
(Latest) J:197599 Pitetti JL, et al., Insulin and IGF1 receptors are essential for XX and XY gonadal differentiation and adrenal development in mice. PLoS Genet. 2013;9(1):e1003160
All references(49)
Other
accession IDs
MGI:1195258

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory