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Mapk13 Gene Detail
Summary
  • Symbol
    Mapk13
  • Name
    mitogen-activated protein kinase 13
  • Synonyms
    p38 delta MAP kinase, SAPK4, Serk4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346864
    NCBI Gene: 26415
  • Gene Overview
    MyGene.info: MAPK13
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:28769315-28778704 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 15.00 cM, cytoband A3-B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    77 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346864
protein coding gene Chr17:28769307-28778704 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023449
protein coding gene Chr17:28221595-28231865 (+)
A/J MGP_AJ_G0023407
protein coding gene Chr17:27270782-27281218 (+)
AKR/J MGP_AKRJ_G0023372
protein coding gene Chr17:27481227-27494127 (+)
BALB/cJ MGP_BALBcJ_G0023412
protein coding gene Chr17:27548826-27561265 (+)
C3H/HeJ MGP_C3HHeJ_G0023173
protein coding gene Chr17:27880079-27889045 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023854
protein coding gene Chr17:29355190-29366563 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021329
protein coding gene Chr17:24627936-24637263 (+)
CAST/EiJ MGP_CASTEiJ_G0022674
protein coding gene Chr17:27852361-27862638 (+)
CBA/J MGP_CBAJ_G0023147
protein coding gene Chr17:30434398-30443475 (+)
DBA/2J MGP_DBA2J_G0023278
protein coding gene Chr17:26819731-26829170 (+)
FVB/NJ MGP_FVBNJ_G0023248
protein coding gene Chr17:26648040-26657107 (+)
LP/J MGP_LPJ_G0023356
protein coding gene Chr17:28470107-28479161 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023266
protein coding gene Chr17:29818094-29827983 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023896
protein coding gene Chr17:27924853-27934313 (+)
PWK/PhJ MGP_PWKPhJ_G0022424
protein coding gene Chr17:25645833-25656603 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022242
protein coding gene Chr17:25932703-25941500 (+)
WSB/EiJ MGP_WSBEiJ_G0022736
protein coding gene Chr17:27910064-27919933 (+)



Homology
more
  • Human Ortholog
    MAPK13, mitogen-activated protein kinase 13
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAPK13, mitogen-activated protein kinase 13
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MAPK 13, MAPK-13, p38delta, PRKM13, SAPK4
  • Links
    NCBI Gene ID: 5603
    neXtProt AC: NX_O15264
    UniProt: O15264

  • Chr Location
    6p21.31; chr6:36130484-36144524 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit improved glucose tolerance, increased insulin secretion, decreased blood glucose, and decreased susceptibility to diet- or chemically-induced diabetes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26415 NCBI Gene Model | MGI Sequence Detail 9390 C57BL/6J ±  kb
    transcript NM_011950 RefSeq | MGI Sequence Detail 1406 Not Specified  
    polypeptide Q9Z1B7 UniProt | EBI | MGI Sequence Detail 366 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      cDNA 51

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1195258
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 9
      Gene Ontology 7
      Phenotypes 18
    • Earliest
      J:38682 Foltz IN, et al., Hemopoietic growth factors with the exception of interleukin-4 activate the p38 mitogen-activated protein kinase pathway. J Biol Chem. 1997 Feb 7;272(6):3296-301
    • Latest
      J:263689 Matesanz N, et al., p38alpha blocks brown adipose tissue thermogenesis through p38delta inhibition. PLoS Biol. 2018 Jul;16(7):e2004455

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory