About   Help   FAQ
Nr5a2
Gene Detail
 Symbol
Name
ID
Nr5a2
nuclear receptor subfamily 5, group A, member 2
MGI:1346834
Synonyms D1Ertd308e, Ftf, LRH-1, UF2-H3B
Feature Type protein coding gene
Genetic Map
Chromosome 1
59.98 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:136843584-136960427 bp, - strand
From Ensembl annotation of GRCm38

  116844 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20827  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: steroidogenic factor-like nuclear receptor
Gene Tree: Nr5a2

Human
homologs
Human Homolog NR5A2, nuclear receptor subfamily 5, group A, member 2
NCBI Gene ID 2494
neXtProt AC  NX_O00482
Human Synonyms  B1F, B1F2, CPF, FTF, FTZ-F1, FTZ-F1beta, hB1F-2, LRH1, LRH-1
Human Chr (Location)  1q32.1; chr1:200027602-200177424 (+)  GRCh38
Alleles
and
phenotypes
All alleles(94) : Targeted(8) Gene trapped(86)
 
Mice homozygous for disruptions in this gene die around embryonic day 7.5. Heterozygotes are essentially normal but with lower plasma cholesterol, increased bile acids, and shorter intestinal crypt length.
 
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process bile acid metabolic process, cholesterol homeostasis, ...
Component cytoplasm, nucleus
Function DNA binding, double-stranded DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (28 records)
Data Summary: Results (371)    Tissues (231)    Images (63)
Theiler Stages: 2, 3, 4, 5, 8, 9, 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 25, 28
Assay TypeResults
RNA in situ 285
RT-PCR 86
cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(20) Genomic(1) cDNA(12) Primer pair(7)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000026398 (Evidence)
Entrez Gene26424 (Evidence)
DFCITC1586407, TC1609002, TC1631802, TC1639182
DoTSDT.101136289, DT.101339533, DT.102542852, DT.110884454, DT.488491, DT.489032
NIA Mouse Gene IndexU021824
PDB3F5C, 1PK5, 1ZH7
Consensus CDS ProjectCCDS15328.1, CCDS48382.1
International Mouse Knockout Project StatusNr5a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026398 Ensembl Gene Model | MGI Sequence Detail 116844 C57BL/6J ±  kb
transcript ENSMUST00000027649 Ensembl | MGI Sequence Detail 3699 Not Applicable 
polypeptide ENSMUSP00000027649 Ensembl | MGI Sequence Detail 560 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(10) UniProt(3)
Polymorphisms SNPs within 2kb(1366 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR001723 Steroid hormone receptor
InterPro IPR016355 Steroidogenic factor 1
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000011412 nuclear receptor subfamily 5 group A member 2
References (Earliest) J:33569 Galarneau L, et al., The alpha1-fetoprotein locus is activated by a nuclear receptor of the Drosophila FTZ-F1 family. Mol Cell Biol. 1996 Jul;16(7):3853-65
(Latest) J:200000 Zhang C, et al., Liver receptor homolog-1 is essential for pregnancy. Nat Med. 2013 Aug;19(8):1061-6
All references(89)
Other
accession IDs
MGI:1098732, MGI:1203501, MGI:2684066

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/08/2014
MGI 5.17
The Jackson Laboratory