Nr5a2
Gene Detail

Symbol Name ID

Nr5a2 nuclear receptor subfamily 5, group A, member 2 MGI:1346834

Synonyms

D1Ertd308e, Ftf, LRH-1, UF2-H3B

Feature Type

protein coding gene

Genetic Map

Chromosome 1

59.98 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr1:136843584-136960427 bp, - strand From Ensembl annotation of GRCm38   116844 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20827  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: steroidogenic factor-like nuclear receptor
Gene Tree: Nr5a2

Human homologs

Human Homolog		NR5A2, nuclear receptor subfamily 5, group A, member 2
NCBI Gene ID		2494
neXtProt AC		NX_O00482
Human Synonyms		B1F, B1F2, CPF, FTF, FTZ-F1, FTZ-F1beta, hB1F-2, LRH1, LRH-1
Human Chr (Location)		1q32.1; chr1:199996770-200146552 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(94) : Targeted(8) Gene trapped(86)
 

Mice homozygous for disruptions in this gene die around embryonic day 7.5. Heterozygotes are essentially normal but with lower plasma cholesterol, increased bile acids, and shorter intestinal crypt length.

 

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	bile acid metabolic process, cholesterol homeostasis, ...
Component	cytoplasm, nucleus
Function	DNA binding, double-stranded DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (27 records)
Data Summary: Results (325)    Tissues (205)    Images (41)
Theiler Stages: 2, 3, 4, 5, 8, 9, 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 25, 28

Assay Type	Results
RNA in situ	239
RT-PCR	86

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) Genomic(1) cDNA(11) Primer pair(7)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000026398 (Evidence)
Entrez Gene	26424 (Evidence)
DFCI	TC1586407, TC1609002, TC1631802, TC1639182
DoTS	DT.101136289, DT.101339533, DT.102542852, DT.110884454, DT.488491, DT.489032
NIA Mouse Gene Index	U021824
PDB	3F5C, 1PK5, 1ZH7
Consensus CDS Project	CCDS15328.1, CCDS48382.1
International Mouse Knockout Project Status	Nr5a2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000026398	Ensembl Gene Model | MGI Sequence Detail	116844	C57BL/6J
transcript	ENSMUST00000027649	Ensembl | MGI Sequence Detail	3699	Not Applicable
polypeptide	ENSMUSP00000027649	Ensembl | MGI Sequence Detail	560	Not Applicable

All sequences(35) RefSeq(4) UniProt(3)

Polymorphisms

SNPs(1129 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008946	Nuclear hormone receptor, ligand-binding
InterPro	IPR000536	Nuclear hormone receptor, ligand-binding, core
InterPro	IPR001723	Steroid hormone receptor
InterPro	IPR016355	Steroidogenic factor 1
InterPro	IPR013088	Zinc finger, NHR/GATA-type
InterPro	IPR001628	Zinc finger, nuclear hormone receptor-type
Protein Ontology	PR:000011412	nuclear receptor subfamily 5 group A member 2

References

(Earliest) J:33569 Galarneau L, et al., The alpha1-fetoprotein locus is activated by a nuclear receptor of the Drosophila FTZ-F1 family. Mol Cell Biol. 1996 Jul;16(7):3853-65
(Latest) J:190077 Oosterveer MH, et al., LRH-1-dependent glucose sensing determines intermediary metabolism in liver. J Clin Invest. 2012 Aug 1;122(8):2817-26
All references(86)

Other accession IDs

MGI:1098732, MGI:1203501, MGI:2684066