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Nr5a2
Gene Detail
Symbol

Name
ID
Nr5a2
nuclear receptor subfamily 5, group A, member 2
MGI:1346834
Synonyms
D1Ertd308e, Ftf, LRH-1, UF2-H3B
Feature Type
protein coding gene
Genetic Map
Chromosome 1
59.98 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:136842571-136960448 bp, - strand
From NCBI annotation of GRCm38

  117878 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20827  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: steroidogenic factor-like nuclear receptor
Gene Tree: Nr5a2

Human
homologs
Human Homolog NR5A2, nuclear receptor subfamily 5, group A, member 2
NCBI Gene ID 2494
neXtProt AC  NX_O00482
Human Synonyms  B1F, B1F2, CPF, FTF, FTZ-F1, FTZ-F1beta, hB1F-2, LRH1, LRH-1
Human Chr (Location)  1q32.1; chr1:200027602-200177424 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(94) : Gene trapped(86) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene die around embryonic day 7.5. Heterozygotes are essentially normal but with lower plasma cholesterol, increased bile acids, and shorter intestinal crypt length.
 
Interactions
Nr5a2 interacts with 303 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process bile acid metabolic process, cholesterol homeostasis, ...
Component cytoplasm, nucleus
Function DNA binding, double-stranded DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (31 records)
Data Summary: Results (364)    Tissues (233)    Images (63)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 285
RT-PCR 79
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(1) cDNA(12) Primer pair(7)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000026398 (Evidence)
Entrez Gene26424 (Evidence)
DFCITC1631802, TC1639182, TC1586407, TC1609002
DoTSDT.488491, DT.110884454, DT.102542852, DT.101339533, DT.101136289, DT.489032
NIA Mouse Gene IndexU021824
PDB3F5C, 1PK5, 1ZH7
Consensus CDS ProjectCCDS15328.1, CCDS48382.1
International Mouse Knockout Project StatusNr5a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 26424 NCBI Gene Model | MGI Sequence Detail 117878 C57BL/6J ±  kb
transcript NM_030676 RefSeq | MGI Sequence Detail 3720 C57BL/6 
polypeptide P45448 UniProt | EBI | MGI Sequence Detail 560 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(10) UniProt(5)
Polymorphisms
SNPs within 2kb(1370 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR001723 Steroid hormone receptor
InterPro IPR016355 Steroidogenic factor 1
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000011412 nuclear receptor subfamily 5 group A member 2
Graphical View of Protein Domain Structure
References
(Earliest) J:33569 Galarneau L, et al., The alpha1-fetoprotein locus is activated by a nuclear receptor of the Drosophila FTZ-F1 family. Mol Cell Biol. 1996 Jul;16(7):3853-65
(Latest) J:214089 Hale MA, et al., The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis. Development. 2014 Aug;141(16):3123-33
All references(95)
Other
accession IDs
MGI:1098732, MGI:1203501, MGI:2684066

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory