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Psmb8 Gene Detail
Summary
  • Symbol
    Psmb8
  • Name
    proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
  • Synonyms
    Lmp7, Lmp-7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346527
    NCBI Gene: 16913
  • Gene Overview
    MyGene.info: PSMB8
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34198195-34201454 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346527
protein coding gene Chr17:34197721-34201454 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023563
protein coding gene Chr17:34199889-34204392 (+)
A/J MGP_AJ_G0023525
protein coding gene Chr17:33039466-33043149 (+)
AKR/J MGP_AKRJ_G0023490
protein coding gene Chr17:33424504-33428189 (+)
BALB/cJ MGP_BALBcJ_G0023529
protein coding gene Chr17:33197303-33208712 (+)
C3H/HeJ MGP_C3HHeJ_G0023289
protein coding gene Chr17:33774281-33778764 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023969
protein coding gene Chr17:35491856-35498447 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021448
protein coding gene Chr17:30529604-30533369 (+)
CAST/EiJ MGP_CASTEiJ_G0022789
protein coding gene Chr17:33879552-33883226 (+)
CBA/J MGP_CBAJ_G0023267
protein coding gene Chr17:36940170-36948877 (+)
DBA/2J MGP_DBA2J_G0023396
protein coding gene Chr17:32392836-32396586 (+)
FVB/NJ MGP_FVBNJ_G0023362
protein coding gene Chr17:32253011-32257069 (+)
LP/J MGP_LPJ_G0023473
protein coding gene Chr17:34469315-34473764 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023385
protein coding gene Chr17:35923317-35926992 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024012
protein coding gene Chr17:33765285-33768986 (+)
PWK/PhJ MGP_PWKPhJ_G0022539
protein coding gene Chr17:31325643-31331139 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022354
protein coding gene Chr17:31718751-31722205 (+)
WSB/EiJ MGP_WSBEiJ_G0022850
protein coding gene Chr17:33800882-33804581 (+)



Homology
more
  • Human Ortholog
    PSMB8, proteasome subunit beta 8
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PSMB8, proteasome subunit beta 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALDD, D6S216, D6S216E, JMP, LMP7, NKJO, PRAAS1, PSMB5i, RING10
  • Links
    NCBI Gene ID: 5696
    neXtProt AC: NX_P28062
    UniProt: P28062

  • Chr Location
    6p21.32; chr6:32840717-32844935 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display an essentially normal phenotype. However they have a reduced ability to process MHC class I restricted antigens.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16913 NCBI Gene Model | MGI Sequence Detail 3260 C57BL/6J ±  kb
transcript NM_010724 RefSeq | MGI Sequence Detail 1223 C57BL/6  
polypeptide P28063 UniProt | EBI | MGI Sequence Detail 276 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    Genomic 3
    cDNA 21

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-11822, MGD-MRK-11824, MGI:96798
References
more
  • Summaries
    All 98
    Developmental Gene Expression 1
    Gene Ontology 10
    Phenotypes 52
  • Earliest
    J:8266 Monaco JJ, et al., The LMP antigens: a stable MHC-controlled multisubunit protein complex. Hum Immunol. 1986 Apr;15(4):416-26
  • Latest
    J:255576 Hewing B, et al., Immunoproteasome subunit ss5i/LMP7-deficiency in atherosclerosis. Sci Rep. 2017 Oct 17;7(1):13342

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory