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Psmb8
Gene Detail
Symbol

Name
ID
Psmb8
proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
MGI:1346527
Synonyms
Lmp7, Lmp-7
Feature Type
protein coding gene
Genetic Map
Chromosome 17
17.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:34197721-34201454 bp, + strand
From VEGA annotation of GRCm38

  3734 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56499  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PSMB8
Gene Tree: Psmb8

Human
homologs
PSMB8, proteasome (prosome, macropain) subunit, beta type, 8
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5696
neXtProt AC: NX_P28062

Human Synonyms: ALDD, D6S216, D6S216E, JMP, LMP7, NKJO, PSMB5i, RING10

Human Chr (Location): 6p21.3; chr6:32840717-32844935 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PSMB8

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene display an essentially normal phenotype. However they have a reduced ability to process MHC class I restricted antigens.
 
Interactions
Psmb8 interacts with 15 markers (Mir134, Mir194-1, Mir367, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process antigen processing and presentation, cell differentiation, ...
Component cytoplasm, extracellular exosome, ...
Function endopeptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (6)    Tissues (1)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 6
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase psmb8 ; ZFIN psmb8a    NEW 
Molecular
reagents
All nucleic(23) Genomic(3) cDNA(20)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000037118 (Evidence)
Ensembl Gene Model ENSMUSG00000024338 (Evidence)
Entrez Gene 16913 (Evidence)
DFCI TC1574225, TC1624940
DoTS DT.99860280, DT.55175214, DT.94270856, DT.94291729, DT.532504, DT.101721542
NIA Mouse Gene Index U017848
EC 3.4.25.1
PDB 3UNF, 3UNH
Consensus CDS Project CCDS50073.1
International Mouse Phenotyping Consortium Status Psmb8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037118 VEGA Gene Model | MGI Sequence Detail 3734 C57BL/6J ±  kb
transcript OTTMUST00000095570 VEGA | MGI Sequence Detail 1628 Not Applicable 
polypeptide OTTMUSP00000053327 VEGA | MGI Sequence Detail 276 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(77 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000243 Peptidase T1A, proteasome beta-subunit
InterPro IPR016050 Proteasome, beta-type subunit, conserved site
InterPro IPR023333 Proteasome B-type subunit
InterPro IPR001353 Proteasome, subunit alpha/beta
Protein Ontology PR:000013376 proteasome subunit beta type-8
References
(Earliest) J:8266 Monaco JJ, et al., The LMP antigens: a stable MHC-controlled multisubunit protein complex. Hum Immunol. 1986 Apr;15(4):416-26
(Latest) J:206749 Cui Z, et al., Identification of the immunoproteasome as a novel regulator of skeletal muscle differentiation. Mol Cell Biol. 2014 Jan;34(1):96-109
All references(86)
Other
accession IDs
MGD-MRK-11822, MGD-MRK-11824, MGI:96798

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory