Psmb8
Gene Detail

Symbol Name ID

Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) MGI:1346527

Synonyms

Lmp7, Lmp-7

Feature Type

protein coding gene

Genetic Map

Chromosome 17

17.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr17:34197721-34201454 bp, + strand From VEGA annotation of GRCm38   3734 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56499  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Psmb8

Human homologs

Human Homolog		PSMB8, proteasome (prosome, macropain) subunit, beta type, 8
NCBI Gene ID		5696
neXtProt AC		NX_P28062
Human Synonyms		ALDD, D6S216, D6S216E, JMP, LMP7, NKJO, PSMB5i, RING10
Human Chr (Location)		6p21.3; chr6:32808494-32812712 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PSMB8

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for disruptions in this gene display an essentially normal phenotype. However they have a reduced ability to process MHC class I restricted antigens.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	antigen processing and presentation, cell differentiation, ...
Component	cytoplasm, nucleus, ...
Function	endopeptidase activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (6)    Tissues (1)    Images (6)
Theiler Stages: 23

Assay Type	Results
RNA in situ	6

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) Genomic(3) cDNA(20)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000037118 (Evidence)
Ensembl Gene Model	ENSMUSG00000024338 (Evidence)
Entrez Gene	16913 (Evidence)
DFCI	TC1574225, TC1624940
DoTS	DT.101721542, DT.532504, DT.55175214, DT.94270856, DT.94291729, DT.99860280
NIA Mouse Gene Index	U017848
EC	3.4.25.1
PDB	3UNF, 3UNH
Consensus CDS Project	CCDS50073.1
International Mouse Knockout Project Status	Psmb8

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037118	VEGA Gene Model | MGI Sequence Detail	3734	C57BL/6J
transcript	OTTMUST00000095570	VEGA | MGI Sequence Detail	1628	Not Applicable
polypeptide	OTTMUSP00000053327	VEGA | MGI Sequence Detail	276	Not Applicable

All sequences(45) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(36 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000243	Peptidase T1A, proteasome beta-subunit
InterPro	IPR016050	Proteasome, beta-type subunit, conserved site
InterPro	IPR023333	Proteasome B-type subunit
InterPro	IPR001353	Proteasome, subunit alpha/beta
Protein Ontology	PR:000013376	proteasome subunit beta type-8

References

(Earliest) J:8266 Monaco JJ, et al., The LMP antigens: a stable MHC-controlled multisubunit protein complex. Hum Immunol. 1986 Apr;15(4):416-26
(Latest) J:193666 Nathan JA, et al., Immuno- and constitutive proteasomes do not differ in their abilities to degrade ubiquitinated proteins. Cell. 2013 Feb 28;152(5):1184-94
All references(82)

Other accession IDs

MGD-MRK-11822, MGD-MRK-11824, MGI:96798