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Sgcd
Gene Detail
Symbol

Name
ID
Sgcd
sarcoglycan, delta (dystrophin-associated glycoprotein)
MGI:1346525
Synonyms
delta-SG
Feature Type
protein coding gene
Genetic Map
Chromosome 11
28.09 cM, cytoband B1.2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:46896253-47988969 bp, - strand
From VEGA annotation of GRCm38

  1092717 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:285  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: sarcoglycan, beta/gamma/delta/zeta types
Gene Tree: Sgcd

Human
homologs
Human Homolog SGCD, sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
NCBI Gene ID 6444
neXtProt AC  NX_Q92629
Human Synonyms  35DAG, CMD1L, DAGD, SGCDP, SGD, SG-delta
Human Chr (Location)  5q33-q34; chr5:156035139-156767788 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human SGCD
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene display cardiomyopathy and muscular dystrophy.
 
Human Diseases Modeled Using Mouse Sgcd (2)    Alleles Annotated to Human Diseases(2)   
Interactions
Sgcd interacts with 266 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cardiac muscle tissue development, heart contraction, ...
Component cytoplasm, cytoskeleton, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (27)    Tissues (2)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 27
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005512 (Evidence)
Ensembl Gene ModelENSMUSG00000020354 (Evidence)
Entrez Gene24052 (Evidence)
UniGene338890
DFCITC1588875
DoTSDT.40178762
NIA Mouse Gene IndexU032704
Consensus CDS ProjectCCDS24584.1
International Mouse Knockout Project StatusSgcd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005512 VEGA Gene Model | MGI Sequence Detail 1092717 C57BL/6J ±  kb
transcript OTTMUST00000012261 VEGA | MGI Sequence Detail 1617 Not Applicable 
polypeptide OTTMUSP00000005662 VEGA | MGI Sequence Detail 289 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(8) UniProt(7)
Polymorphisms
SNPs within 2kb(4398 from dbSNP Build 137)    SNPs within 2kb including multiple locations(4424)
Protein-related
information
ResourceIDDescription
InterPro IPR006875 Sarcoglycan complex subunit protein
Protein Ontology PR:000014783 delta-sarcoglycan
References
(Earliest) J:57106 Noguchi S, et al., Developmental expression of sarcoglycan gene products in cultured myocytes. Biochem Biophys Res Commun. 1999 Aug 19;262(1):88-93
(Latest) J:212146 Burr AR, et al., Na+ dysregulation coupled with Ca2+ entry through NCX1 promotes muscular dystrophy in mice. Mol Cell Biol. 2014 Jun;34(11):1991-2002
All references(68)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory