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Sgcd
Gene Detail
Symbol

Name
ID
Sgcd
sarcoglycan, delta (dystrophin-associated glycoprotein)
MGI:1346525
Synonyms
delta-SG
Feature Type
protein coding gene
Genetic Map
Chromosome 11
28.09 cM, cytoband B1.2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:46896253-47988969 bp, - strand
From VEGA annotation of GRCm38

  1092717 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:285  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SGCD
Protein SuperFamily: sarcoglycan, beta/gamma/delta/zeta types
Gene Tree: Sgcd

Human
homologs
SGCD, sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6444
neXtProt AC: NX_Q92629

Human Synonyms: 35DAG, CMD1L, DAGD, SGCDP, SGD, SG-delta

Human Chr (Location): 5q33-q34; chr5:156117934-156767788 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human SGCD

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene display cardiomyopathy and muscular dystrophy.
 
Human Diseases Modeled in Mice Using Sgcd (2)    Mutations Annotated to Human Diseases (2)   
Interactions
Sgcd interacts with 266 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cardiac muscle tissue development, heart contraction, ...
Component cytoplasm, cytoskeleton, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (27)    Tissues (2)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 27
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN sgcd    NEW 
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000005512 (Evidence)
Ensembl Gene Model ENSMUSG00000020354 (Evidence)
Entrez Gene 24052 (Evidence)
UniGene 338890
DFCI TC1588875
DoTS DT.40178762
NIA Mouse Gene Index U032704
Consensus CDS Project CCDS24584.1
International Mouse Phenotyping Consortium Status Sgcd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005512 VEGA Gene Model | MGI Sequence Detail 1092717 C57BL/6J ±  kb
transcript OTTMUST00000012261 VEGA | MGI Sequence Detail 1617 Not Applicable 
polypeptide OTTMUSP00000005662 VEGA | MGI Sequence Detail 289 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(12) UniProt(3)
Polymorphisms
SNPs within 2kb(4398 from dbSNP Build 137)    SNPs within 2kb including multiple locations(4424)
Protein-related
information
ResourceIDDescription
InterPro IPR027661 Delta-sarcoglycan
InterPro IPR006875 Sarcoglycan complex subunit protein
Protein Ontology PR:000014783 delta-sarcoglycan
References
(Earliest) J:57106 Noguchi S, et al., Developmental expression of sarcoglycan gene products in cultured myocytes. Biochem Biophys Res Commun. 1999 Aug 19;262(1):88-93
(Latest) J:220869 Spinazzola JM, et al., Gamma-sarcoglycan is required for the response of archvillin to mechanical stimulation in skeletal muscle. Hum Mol Genet. 2015 May 1;24(9):2470-81
All references(71)
Disease annotation references (4)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory