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Sgcb Gene Detail
Summary
  • Symbol
    Sgcb
  • Name
    sarcoglycan, beta (dystrophin-associated glycoprotein)
  • Synonyms
    beta-SG
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346523
    NCBI Gene: 24051
  • Gene Overview
    MyGene.info: SGCB
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:73632749-73647790 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15042 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 38.89 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    SGCB, sarcoglycan beta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SGCB, sarcoglycan beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    A3b, LGMD2E, SGC
  • Links
    NCBI Gene ID: 6443
    neXtProt AC: NX_Q16585
    UniProt: Q16585

  • Chr Location
    4q12; chr4:52020695-52038319 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Sgcb mouse models; 1 with human SGCB associations

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    263 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit muscular dystrophy and cardiomyopathy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000055946 VEGA Gene Model | MGI Sequence Detail 15042 C57BL/6J ±  kb
    transcript OTTMUST00000138417 VEGA | MGI Sequence Detail 3786 Not Applicable  
    polypeptide OTTMUSP00000072782 VEGA | MGI Sequence Detail 320 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      203 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      cDNA 55

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:2140958, MGI:2140980
    References
    more
    • Summaries
      All 301
      Developmental Gene Expression 4
      Diseases 3
      Gene Ontology 6
      Phenotypes 263
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:263139 Philp AR, et al., Kcnn4 is a modifier gene of intestinal cystic fibrosis preventing lethality in the Cftr-F508del mouse. Sci Rep. 2018 Jun 18;8(1):9320

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory