Sgcb
Gene Detail

Symbol Name ID

Sgcb sarcoglycan, beta (dystrophin-associated glycoprotein) MGI:1346523

Synonyms

beta-SG

Feature Type

protein coding gene

Genetic Map

Chromosome 5

38.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr5:73632749-73647713 bp, - strand From Ensembl annotation of GRCm38   14965 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:195  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: sarcoglycan, beta/gamma/delta/zeta types
Gene Tree: Sgcb

Human homologs

Human Homolog		SGCB, sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
NCBI Gene ID		6443
neXtProt AC		NX_Q16585
Human Synonyms		A3b, LGMD2E, SGC
Human Chr (Location)		4q12; chr4:52886861-52904485 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SGCB

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for a null allele exhibit muscular dystrophy and cardiomyopathy.

 
Human Diseases Modeled Using Mouse Sgcb (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	cardiocyte differentiation, cellular membrane organization
Component	cytoplasm, cytoskeleton, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (96)    Tissues (36)    Images (24)
Theiler Stages: 17, 20, 23

Assay Type	Results
RNA in situ	96

cDNA source data(51)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(53) cDNA(53)
Microarray probesets(9)

Other database links

Ensembl Gene Model	ENSMUSG00000029156 (Evidence)
Entrez Gene	24051 (Evidence)
UniGene	89310
DFCI	TC1576916, TC1626031, TC1720414
DoTS	DT.486360, DT.55126365, DT.55173955
NIA Mouse Gene Index	U026300
Consensus CDS Project	CCDS19344.1
International Mouse Knockout Project Status	Sgcb

Sequences

Length	Strain/Species
genomic	ENSMUSG00000029156	Ensembl Gene Model | MGI Sequence Detail	14965	C57BL/6J
transcript	ENSMUST00000081170	Ensembl | MGI Sequence Detail	3709	Not Applicable
polypeptide	ENSMUSP00000079937	Ensembl | MGI Sequence Detail	320	Not Applicable

All sequences(25) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(94 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006875	Sarcoglycan complex subunit protein
Protein Ontology	PR:000014782	beta-sarcoglycan

References

(Earliest) J:57106 Noguchi S, et al., Developmental expression of sarcoglycan gene products in cultured myocytes. Biochem Biophys Res Commun. 1999 Aug 19;262(1):88-93
(Latest) J:186918 Barnabei MS, et al., Ex vivo stretch reveals altered mechanical properties of isolated dystrophin-deficient hearts. PLoS One. 2012;7(3):e32880
All references(46)

Other accession IDs

MGI:2140958, MGI:2140980