About   Help   FAQ
Sgcb Gene Detail
Summary
  • Symbol
    Sgcb
  • Name
    sarcoglycan, beta (dystrophin-associated glycoprotein)
  • Synonyms
    beta-SG
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346523
    NCBI Gene: 24051
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:73790092-73805080 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 38.89 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    512 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346523
 protein coding gene Chr5:73790092-73805133 (-)
129S1/SvImJ ENSMUSG00200035337
 protein coding gene Chr5:69449378-69464430 (-)
A/J ENSMUSG00195030264
 protein coding gene Chr5:68773998-68789007 (-)
AKR/J ENSMUSG00220003200
 protein coding gene Chr5:68879461-68894525 (-)
BALB/cJ ENSMUSG00180022782
 protein coding gene Chr5:68531032-68546037 (-)
C3H/HeJ ENSMUSG00175025058
 protein coding gene Chr5:70606583-70621720 (-)
C57BL/6NJ ENSMUSG00215004946
 protein coding gene Chr5:69365362-69380405 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027299
 protein coding gene Chr5:66561578-66578213 (-)
CAST/EiJ ENSTCUG00005028800
 protein coding gene Chr5:68350989-68366051 (-)
CBA/J ENSMUSG00210022910
 protein coding gene Chr5:69544656-69559799 (-)
DBA/2J ENSMUSG00185016452
 protein coding gene Chr5:71374470-71389607 (-)
FVB/NJ ENSMUSG00205021713
 protein coding gene Chr5:68297949-68312956 (-)
JF1/MsJ ENSUMUG00000004245
 protein coding gene Chr5:75858835-75873980 (-)
LP/J ENSMUSG00230021064
 protein coding gene Chr5:76023637-76038685 (-)
NOD/ShiLtJ ENSMUSG00190003922
 protein coding gene Chr5:68473308-68488463 (-)
NZO/HlLtJ ENSMUSG00225009298
 protein coding gene Chr5:81094169-81109174 (-)
PWK/PhJ ENSLUMG00010011495
 protein coding gene Chr5:68418636-68433680 (-)
SPRET/EiJ ENSMSPG00010030715
 protein coding gene Chr5:70413690-70428762 (-)
WSB/EiJ ENSIUOG00005017187
 protein coding gene Chr5:71305984-71321059 (-)



Homology
more
  • Human Ortholog
    SGCB, sarcoglycan beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SGCB, sarcoglycan beta
  • Synonyms
    A3b, LGMD2E, LGMDR4, SGC
  • Links
    NCBI Gene ID: 6443
    UniProt: Q16585

  • Chr Location
    4q12; chr4:52020706-52038299 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Sgcb mouse models; 2 with human SGCB associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 3 alleles in 3 genetic backgrounds
    419 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit muscular dystrophy and cardiomyopathy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    693
  • Tissues
    36
  • cDNA Data
    53
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 24051 NCBI Gene Model | MGI Sequence Detail 14989 C57BL/6J ±  kb
    transcript NM_011890 RefSeq | MGI Sequence Detail 3733 C57BL/6  
    polypeptide P82349 UniProt | EBI | MGI Sequence Detail 320 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      cDNA 55

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:2140958, MGI:2140980
    References
    more
    • Summaries
      All 466
      Developmental Gene Expression 4
      Diseases 4
      Gene Ontology 13
      Phenotypes 419
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:390040 Dang L, et al., Activation of Intestinal Mast Cells Contributes to Gut Damage After Cardiac Arrest in Mice. Shock. 2026 Jan 1;65(1):85-92
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory