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Sgcb
Gene Detail
 Symbol
Name
ID
Sgcb
sarcoglycan, beta (dystrophin-associated glycoprotein)
MGI:1346523
Synonyms beta-SG
Feature Type protein coding gene
Genetic Map
Chromosome 5
38.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:73632749-73647713 bp, - strand
From Ensembl annotation of GRCm38

  14965 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:195  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: sarcoglycan, beta/gamma/delta/zeta types
Gene Tree: Sgcb

Human
homologs
Human Homolog SGCB, sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
NCBI Gene ID 6443
neXtProt AC  NX_Q16585
Human Synonyms  A3b, LGMD2E, SGC
Human Chr (Location)  4q12; chr4:52019586-52052400 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SGCB
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit muscular dystrophy and cardiomyopathy.
 
Human Diseases Modeled Using Mouse Sgcb (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Sgcb interacts with 329 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cardiac muscle cell development, membrane organization, ...
Component cytoplasm, cytoskeleton, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (96)    Tissues (36)    Images (24)
Theiler Stages: 17, 20, 23
Assay TypeResults
RNA in situ 96
cDNA source data(52)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(54) cDNA(54)
Microarray probesets(9)
Other database
links
Ensembl Gene ModelENSMUSG00000029156 (Evidence)
Entrez Gene24051 (Evidence)
UniGene89310
DFCITC1576916, TC1626031, TC1720414
DoTSDT.486360, DT.55126365, DT.55173955
NIA Mouse Gene IndexU026300
Consensus CDS ProjectCCDS19344.1
International Mouse Knockout Project StatusSgcb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029156 Ensembl Gene Model | MGI Sequence Detail 14965 C57BL/6J ±  kb
transcript ENSMUST00000081170 Ensembl | MGI Sequence Detail 3709 Not Applicable 
polypeptide ENSMUSP00000079937 Ensembl | MGI Sequence Detail 320 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(206 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006875 Sarcoglycan complex subunit protein
Protein Ontology PR:000014782 beta-sarcoglycan
References (Earliest) J:57106 Noguchi S, et al., Developmental expression of sarcoglycan gene products in cultured myocytes. Biochem Biophys Res Commun. 1999 Aug 19;262(1):88-93
(Latest) J:208398 Korner Z, et al., Bortezomib Partially Improves Laminin alpha2 Chain-Deficient Muscular Dystrophy. Am J Pathol. 2014 May;184(5):1518-28
All references(47)
Disease annotation references (2)
Other
accession IDs
MGI:2140958, MGI:2140980

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory