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Sgcb
Gene Detail
Symbol

Name
ID
Sgcb
sarcoglycan, beta (dystrophin-associated glycoprotein)
MGI:1346523
Synonyms
beta-SG
Feature Type
protein coding gene
Genetic Map
Chromosome 5
38.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:73632749-73647713 bp, - strand
From Ensembl annotation of GRCm38

  14965 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:195  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SGCB
Protein SuperFamily: sarcoglycan, beta/gamma/delta/zeta types
Gene Tree: Sgcb

Human
homologs
SGCB, sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6443
neXtProt AC: NX_Q16585

Human Synonyms: A3b, LGMD2E, SGC

Human Chr (Location): 4q12; chr4:52020695-52038319 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SGCB

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Radiation induced(1) Targeted(4)
Genomic Mutations involving Sgcb (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit muscular dystrophy and cardiomyopathy.
 
Human Diseases Modeled in Mice Using Sgcb (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(4)
Interactions
Sgcb interacts with 329 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cardiac muscle cell development, membrane organization, ...
Component cytoplasm, cytoskeleton, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (96)    Tissues (36)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 96
cDNA source data(52)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase sgcb ; ZFIN sgcb    NEW 
Molecular
reagents
All nucleic(54) cDNA(54)
Microarray probesets(9)
Other database
links
Ensembl Gene Model ENSMUSG00000029156 (Evidence)
Entrez Gene 24051 (Evidence)
UniGene 89310
DFCI TC1576916, TC1626031, TC1720414
DoTS DT.486360, DT.55126365, DT.55173955
NIA Mouse Gene Index U026300
Consensus CDS Project CCDS19344.1
International Mouse Phenotyping Consortium Status Sgcb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029156 Ensembl Gene Model | MGI Sequence Detail 14965 C57BL/6J ±  kb
transcript ENSMUST00000081170 Ensembl | MGI Sequence Detail 3709 Not Applicable 
polypeptide ENSMUSP00000079937 Ensembl | MGI Sequence Detail 320 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(206 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006875 Sarcoglycan complex subunit protein
Protein Ontology PR:000014782 beta-sarcoglycan
References
(Earliest) J:57106 Noguchi S, et al., Developmental expression of sarcoglycan gene products in cultured myocytes. Biochem Biophys Res Commun. 1999 Aug 19;262(1):88-93
(Latest) J:208398 Korner Z, et al., Bortezomib Partially Improves Laminin alpha2 Chain-Deficient Muscular Dystrophy. Am J Pathol. 2014 May;184(5):1518-28
All references(46)
Disease annotation references (2)
Other
accession IDs
MGI:2140958, MGI:2140980

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory