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Igbp1 Gene Detail
Summary
  • Symbol
    Igbp1
  • Name
    immunoglobulin (CD79A) binding protein 1
  • Synonyms
    alpha 4, p52, Pc52, Tap42
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346500
    NCBI Gene: 18518
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:99537897-99559731 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 43.72 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    536 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346500
 protein coding gene ChrX:99537897-99559731 (+)
129S1/SvImJ ENSMUSG00200037907
 protein coding gene ChrX:81250570-81272406 (+)
A/J ENSMUSG00195038351
 protein coding gene ChrX:85012180-85034012 (+)
AKR/J ENSMUSG00220027156
 protein coding gene ChrX:79702907-79724743 (+)
BALB/cJ ENSMUSG00180019998
 protein coding gene ChrX:81722576-81744407 (+)
C3H/HeJ ENSMUSG00175037614
 protein coding gene ChrX:85383075-85404903 (+)
C57BL/6NJ ENSMUSG00215045833
 protein coding gene ChrX:81897171-81919009 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033268
 protein coding gene ChrX:94777739-94799156 (+)
CAST/EiJ ENSTCUG00005040054
 protein coding gene ChrX:82771682-82793284 (+)
CBA/J ENSMUSG00210041028
 protein coding gene ChrX:82153937-82175765 (+)
DBA/2J ENSMUSG00185042489
 protein coding gene ChrX:94590079-94611915 (+)
FVB/NJ ENSMUSG00205024520
 protein coding gene ChrX:81405720-81427557 (+)
JF1/MsJ ENSUMUG00000022182
 protein coding gene ChrX:115178543-115200133 (+)
LP/J ENSMUSG00230011233
 protein coding gene ChrX:101284112-101305947 (+)
NOD/ShiLtJ ENSMUSG00190018142
 protein coding gene ChrX:81301917-81323746 (+)
NZO/HlLtJ ENSMUSG00225045074
 protein coding gene ChrX:106374977-106396813 (+)
PWK/PhJ ENSLUMG00010034540
 protein coding gene ChrX:80455741-80477355 (+)
SPRET/EiJ ENSMSPG00010036054
 protein coding gene ChrX:84738365-84759889 (+)
WSB/EiJ ENSIUOG00005041838
 protein coding gene ChrX:81848262-81869929 (+)



Homology
more
  • Human Ortholog
    IGBP1, immunoglobulin binding protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGBP1, immunoglobulin binding protein 1
  • Synonyms
    alpha4, ALPHA-4, IBP1, MRXS28
  • Links
    NCBI Gene ID: 3476
    UniProt: P78318

  • Chr Location
    Xq13.1; chrX:70133345-70166324 (+)  GRCh38
  • Human Ortholog
    IGBP1C, IGBP1 family member C
  • Synonyms
    IGBP1P2
  • Links
    NCBI Gene ID: 645545
    UniProt: A0A1W2PR95

  • Chr Location
    17q22; chr17:58660424-58692045 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human IGBP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 4 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    613
  • Tissues
    16
  • cDNA Data
    20
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18518 NCBI Gene Model | MGI Sequence Detail 21835 C57BL/6J ±  kb
    transcript NM_008784 RefSeq | MGI Sequence Detail 1518 C57BL/6  
    polypeptide Q61249 UniProt | EBI | MGI Sequence Detail 340 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 2
      cDNA 23
      Primer pair 1
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-32087, MGI:105048, MGI:2147845, MGI:2147906, MGI:2148003, MGI:2148070
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 4
      Gene Ontology 11
      Phenotypes 10
    • Earliest
      J:27712 Kuwahara K, et al., Identification of a 52-kDa molecule (p52) coprecipitated with the Ig receptor-related MB-1 protein that is inducibly phosphorylated by the stimulation with phorbol myristate acetate. J Immunol. 1994 Mar 15;152(6):2742-52
    • Latest
      J:353712 Sakaguchi M, et al., Phosphatase protector alpha4 (alpha4) is involved in adipocyte maintenance and mitochondrial homeostasis through regulation of insulin signaling. Nat Commun. 2022 Oct 14;13(1):6092
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    09/01/2026
    MGI 6.24     		The Jackson Laboratory