Sh3bp2
Gene Detail

Symbol Name ID

Sh3bp2 SH3-domain binding protein 2 MGI:1346349

Synonyms

3BP2

Feature Type

protein coding gene

Genetic Map

Chromosome 5

17.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr5:34525838-34563625 bp, + strand From VEGA annotation of GRCm38   37788 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2276  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Sh3bp2

Human homologs

Human Homolog		SH3BP2, SH3-domain binding protein 2
NCBI Gene ID		6452
neXtProt AC		NX_P78314
Human Synonyms		3BP2, 3BP-2, CRBM, CRPM
Human Chr (Location)		4p16.3; chr4:2794750-2842823 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SH3BP2

Alleles and phenotypes

All alleles(6) : Targeted(5) Gene trapped(1)
 

Nullizygous mutations may lead to higher pre-B cell numbers and impaired B cell receptor signaling or thymus-independent type 2 humoral responses. Homozygosity for a knock-in allele causes premature death, enhanced osteoclast differentiation and TNF production, systemic bone loss and inflammation.

 
Human Diseases Modeled Using Mouse Sh3bp2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (3 annotations)

Function

phospholipid binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (83)    Tissues (9)    Images (24)
Theiler Stages: 23

Assay Type	Results
RNA in situ	83

cDNA source data(32)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(32) cDNA(32)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000026739 (Evidence)
Ensembl Gene Model	ENSMUSG00000054520 (Evidence)
Entrez Gene	24055 (Evidence)
UniGene	5012
DFCI	TC1577452
DoTS	DT.101124989, DT.101380835, DT.40185500, DT.97332677
NIA Mouse Gene Index	U005489
Consensus CDS Project	CCDS19215.1, CCDS51469.1, CCDS51470.1
International Mouse Knockout Project Status	Sh3bp2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026739	VEGA Gene Model | MGI Sequence Detail	37788	C57BL/6J
transcript	OTTMUST00000066134	VEGA | MGI Sequence Detail	3034	Not Applicable
polypeptide	OTTMUSP00000033087	VEGA | MGI Sequence Detail	615	Not Applicable

All sequences(62) RefSeq(8) UniProt(10)

Polymorphisms

SNPs(262 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR000980	SH2 domain
Protein Ontology	PR:000014819	SH3 domain-binding protein 2

References

(Earliest) J:57558 Ren R, et al., Identification of a ten-amino acid proline-rich SH3 binding site. Science. 1993 Feb 19;259(5098):1157-61
(Latest) J:189733 Chen G, et al., The 3BP2 adapter protein is required for chemoattractant-mediated neutrophil activation. J Immunol. 2012 Sep 1;189(5):2138-50
All references(40)