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Sh3bp2 Gene Detail
Summary
  • Symbol
    Sh3bp2
  • Name
    SH3-domain binding protein 2
  • Synonyms
    3BP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346349
    NCBI Gene: 24055
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:34525838-34563641 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 17.89 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    310 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346349
protein coding gene Chr5:34525784-34563641 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029466
protein coding gene Chr5:32769551-32807330 (+)
A/J MGP_AJ_G0029433
protein coding gene Chr5:31684428-31722213 (+)
AKR/J MGP_AKRJ_G0029382
protein coding gene Chr5:32909046-32946830 (+)
BALB/cJ MGP_BALBcJ_G0029443
protein coding gene Chr5:32220038-32257853 (+)
C3H/HeJ MGP_C3HHeJ_G0029165
protein coding gene Chr5:32945595-32983382 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029897
protein coding gene Chr5:34657507-34695170 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027134
protein coding gene Chr5:29463513-29501645 (+)
CAST/EiJ MGP_CASTEiJ_G0028574
protein coding gene Chr5:32006201-32045893 (+)
CBA/J MGP_CBAJ_G0029133
protein coding gene Chr5:35431753-35477456 (+)
DBA/2J MGP_DBA2J_G0029281
protein coding gene Chr5:31854896-31892673 (+)
FVB/NJ MGP_FVBNJ_G0029240
protein coding gene Chr5:31296012-31333739 (+)
LP/J MGP_LPJ_G0029366
protein coding gene Chr5:33185357-33224411 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029270
protein coding gene Chr5:36292396-36330147 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029930
protein coding gene Chr5:32417114-32454899 (+)
PWK/PhJ MGP_PWKPhJ_G0028299
protein coding gene Chr5:30998162-31036426 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028130
protein coding gene Chr5:31852799-31890554 (+)
WSB/EiJ MGP_WSBEiJ_G0028655
protein coding gene Chr5:32494737-32532529 (+)



Homology
more
  • Human Ortholog
    SH3BP2, SH3 domain binding protein 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SH3BP2, SH3 domain binding protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    3BP2, 3BP-2, CRBM, CRPM, RES4-23
  • Links
    NCBI Gene ID: 6452
    neXtProt AC: NX_P78314
    UniProt: P78314

  • Chr Location
    4p16.3; chr4:2793023-2841096 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Sh3bp2 mouse models; 1 with human SH3BP2 associations

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    68 phenotypes from 6 alleles in 7 genetic backgrounds
    12 phenotypes from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Nullizygous mutations may lead to higher pre-B cell numbers and impaired B cell receptor signaling or thymus-independent type 2 humoral responses. Homozygosity for a knock-in allele causes premature death, enhanced osteoclast differentiation and TNF production, systemic bone loss and inflammation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054520 Ensembl Gene Model | MGI Sequence Detail 37804 C57BL/6J ±  kb
    transcript ENSMUST00000118545 Ensembl | MGI Sequence Detail 3034 Not Applicable  
    polypeptide ENSMUSP00000112554 Ensembl | MGI Sequence Detail 615 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 34

      Microarray probesets 4
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 1
      Diseases 3
      Gene Ontology 6
      Phenotypes 46
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:270763 Dimitriou ID, et al., Timed Regulation of 3BP2 Induction Is Critical for Sustaining CD8(+) T Cell Expansion and Differentiation. Cell Rep. 2018 Jul 31;24(5):1123-1135

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/01/2019
    MGI 6.14
    The Jackson Laboratory