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Sh3bp2
Gene Detail
 Symbol
Name
ID
Sh3bp2
SH3-domain binding protein 2
MGI:1346349
Synonyms 3BP2
Feature Type protein coding gene
Genetic Map
Chromosome 5
17.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:34525838-34563625 bp, + strand
From VEGA annotation of GRCm38

  37788 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2276  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Sh3bp2

Human
homologs
Human Homolog SH3BP2, SH3-domain binding protein 2
NCBI Gene ID 6452
neXtProt AC  NX_P78314
Human Synonyms  3BP2, 3BP-2, CRBM, CRPM
Human Chr (Location)  4p16.3; chr4:2793023-2841096 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SH3BP2
Alleles
and
phenotypes
All alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mutations may lead to higher pre-B cell numbers and impaired B cell receptor signaling or thymus-independent type 2 humoral responses. Homozygosity for a knock-in allele causes premature death, enhanced osteoclast differentiation and TNF production, systemic bone loss and inflammation.
 
Human Diseases Modeled Using Mouse Sh3bp2 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (2 annotations)
Function protein binding, SH3 domain binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (83)    Tissues (9)    Images (24)
Theiler Stages: 23
Assay TypeResults
RNA in situ 83
cDNA source data(33)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(33) cDNA(33)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000026739 (Evidence)
Ensembl Gene ModelENSMUSG00000054520 (Evidence)
Entrez Gene24055 (Evidence)
UniGene5012
DFCITC1577452
DoTSDT.101124989, DT.101380835, DT.40185500, DT.97332677
NIA Mouse Gene IndexU005489
Consensus CDS ProjectCCDS19215.1, CCDS51469.1, CCDS51470.1
International Mouse Knockout Project StatusSh3bp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026739 VEGA Gene Model | MGI Sequence Detail 37788 C57BL/6J ±  kb
transcript OTTMUST00000066134 VEGA | MGI Sequence Detail 3034 Not Applicable 
polypeptide OTTMUSP00000033087 VEGA | MGI Sequence Detail 615 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(11) UniProt(10)
Polymorphisms SNPs within 2kb(310 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR000980 SH2 domain
Protein Ontology PR:000014819 SH3 domain-binding protein 2
References (Earliest) J:57558 Ren R, et al., Identification of a ten-amino acid proline-rich SH3 binding site. Science. 1993 Feb 19;259(5098):1157-61
(Latest) J:189733 Chen G, et al., The 3BP2 adapter protein is required for chemoattractant-mediated neutrophil activation. J Immunol. 2012 Sep 1;189(5):2138-50
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory