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Mapk7 Gene Detail
Summary
  • Symbol
    Mapk7
  • Name
    mitogen-activated protein kinase 7
  • Synonyms
    b2b2346Clo, big MAP kinase 1, BMK1, ERK5, Erk5-T
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346347
    NCBI Gene: 23939
  • Gene Overview
    MyGene.info: MAPK7
Location & Maps
more
  • Sequence Map
    Chr11:61488812-61494406 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5595 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 37.96 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MAPK7, mitogen-activated protein kinase 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAPK7, mitogen-activated protein kinase 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BMK1, ERK4, ERK5, PRKM7
  • Links
    NCBI Gene ID: 5598
    neXtProt AC: NX_Q13164
    UniProt: Q13164

  • Chr Location
    17p11.2; chr17:19377721-19383544 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    60 phenotypes from 7 alleles in 7 genetic backgrounds
    27 images
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    9
  • Genomic Mutations
    1 involving Mapk7
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
Homozygous inactivation of this gene leads to embryonic growth retardation and midgestational lethality due to multiple developmental anomalies and vascular remodelling, cardiac development, and placental defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005833 VEGA Gene Model | MGI Sequence Detail 5595 C57BL/6J ±  kb
transcript OTTMUST00000012963 VEGA | MGI Sequence Detail 3019 Not Applicable  
polypeptide OTTMUSP00000006027 VEGA | MGI Sequence Detail 806 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    20 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 76
    cDNA 74
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGI:5554536
References
more
  • Summaries
    All 86
    Developmental Gene Expression 10
    Gene Ontology 12
    Phenotypes 37
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:239930 de Jong PR, et al., ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation. Nat Commun. 2016 May 17;7:11551

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory