Mapk7
Gene Detail

Symbol Name ID

Mapk7 mitogen-activated protein kinase 7 MGI:1346347

Synonyms

big MAP kinase 1, BMK1, ERK5, Erk5-T

Feature Type

protein coding gene

Genetic Map

Chromosome 11

37.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:61488812-61494406 bp, - strand From VEGA annotation of GRCm38   5595 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2060  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Mapk7

Human homologs

Human Homolog		MAPK7, mitogen-activated protein kinase 7
NCBI Gene ID		5598
neXtProt AC		NX_Q13164
Human Synonyms		BMK1, ERK4, ERK5, PRKM7
Human Chr (Location)		17p11.2; chr17:19281034-19286857 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(8) Gene trapped(1)
 

Homozygous inactivation of this gene leads to embryonic growth retardation and midgestational lethality due to multiple developmental anomalies and vascular remodelling, cardiac development, and placental defects.

 
Phenotype Images(13)

Gene Ontology (GO) classifications

All GO classifications: (40 annotations)

Process	apoptotic process, cell cycle, ...
Component	cytoplasm, cytosol, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (84)    Tissues (27)    Images (29)
Theiler Stages: 2, 3, 4, 5, 23, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	66
Western blot	1
RT-PCR	13

cDNA source data(73)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(76) cDNA(74) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000005833 (Evidence)
Ensembl Gene Model	ENSMUSG00000001034 (Evidence)
Entrez Gene	23939 (Evidence)
UniGene	38172
DFCI	TC1578918, TC1590947, TC1595260, TC1596123, TC1597101, TC1607459
NIA Mouse Gene Index	U032885
EC	2.7.11.24
Consensus CDS Project	CCDS24814.1
International Mouse Knockout Project Status	Mapk7

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005833	VEGA Gene Model | MGI Sequence Detail	5595	C57BL/6J
transcript	OTTMUST00000012963	VEGA | MGI Sequence Detail	3019	Not Applicable
polypeptide	OTTMUSP00000006027	VEGA | MGI Sequence Detail	806	Not Applicable

All sequences(70) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(9 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003527	Mitogen-activated protein (MAP) kinase, conserved site
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000010159	mitogen-activated protein kinase 7

References

(Earliest) J:57565 Kamakura S, et al., Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus. J Biol Chem. 1999 Sep 10;274(37):26563-71
(Latest) J:193862 Wang W, et al., Extracellular signal-regulated kinase 5 (ERK5) mediates prolactin-stimulated adult neurogenesis in the subventricular zone and olfactory bulb. J Biol Chem. 2013 Jan 25;288(4):2623-31
All references(65)