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Mapk7 Gene Detail
Summary
  • Symbol
    Mapk7
  • Name
    mitogen-activated protein kinase 7
  • Synonyms
    b2b2346Clo, big MAP kinase 1, BMK1, ERK5, Erk5-T
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346347
    NCBI Gene: 23939
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:61379638-61385101 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 37.96 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    161 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346347
 protein coding gene Chr11:61379638-61385232 (-)
129S1/SvImJ ENSMUSG00200036149
 protein coding gene Chr11:58297599-58303693 (-)
A/J ENSMUSG00195038230
 protein coding gene Chr11:58338745-58344834 (-)
AKR/J ENSMUSG00220039924
 protein coding gene Chr11:58439768-58445862 (-)
BALB/cJ ENSMUSG00180045855
 protein coding gene Chr11:58391851-58397940 (-)
C3H/HeJ ENSMUSG00175037200
 protein coding gene Chr11:58355960-58362049 (-)
C57BL/6NJ ENSMUSG00215019450
 protein coding gene Chr11:58098907-58104996 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016478
 protein coding gene Chr11:56309252-56315011 (-)
CAST/EiJ ENSTCUG00005038826
 protein coding gene Chr11:57884762-57890853 (-)
CBA/J ENSMUSG00210034671
 protein coding gene Chr11:58188981-58195070 (-)
DBA/2J ENSMUSG00185039200
 protein coding gene Chr11:58371854-58377936 (-)
FVB/NJ ENSMUSG00205027333
 protein coding gene Chr11:58262357-58268451 (-)
JF1/MsJ ENSUMUG00000040625
 protein coding gene Chr11:58779796-58785904 (-)
LP/J ENSMUSG00230044935
 protein coding gene Chr11:59518879-59524973 (-)
NOD/ShiLtJ ENSMUSG00190042469
 protein coding gene Chr11:58371345-58377439 (-)
NZO/HlLtJ ENSMUSG00225044415
 protein coding gene Chr11:61662258-61668352 (-)
PWK/PhJ ENSLUMG00010023703
 protein coding gene Chr11:58302220-58308332 (-)
SPRET/EiJ ENSMSPG00010030230
 protein coding gene Chr11:58974726-58980767 (-)
WSB/EiJ ENSIUOG00005035308
 protein coding gene Chr11:58289631-58295725 (-)



Homology
more
  • Human Ortholog
    MAPK7, mitogen-activated protein kinase 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAPK7, mitogen-activated protein kinase 7
  • Synonyms
    BMK1, ERK4, ERK5, PRKM7
  • Links
    NCBI Gene ID: 5598
    UniProt: Q13164

  • Chr Location
    17p11.2; chr17:19377721-19383544 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    59 phenotypes from 7 alleles in 7 genetic backgrounds
    27 images
    56 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to embryonic growth retardation and midgestational lethality due to multiple developmental anomalies and vascular remodelling, cardiac development, and placental defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    75
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    52
  • cDNA Data
    75
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23939 NCBI Gene Model | MGI Sequence Detail 5464 C57BL/6J ±  kb
    transcript NM_001291035 RefSeq | MGI Sequence Detail 3216 C57BL/6  
    polypeptide Q9WVS8 UniProt | EBI | MGI Sequence Detail 806 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 81
      cDNA 77
      Primer pair 4
      Antibodies 8

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:5554536
    References
    more
    • Summaries
      All 135
      Developmental Gene Expression 17
      Gene Ontology 19
      Phenotypes 56
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:374279 Cervantes JA, et al., Signaling via C-C Chemokine Ligand 19 and Extracellular Regulated Kinase 5 in T Cells Limits the Humoral Adaptive Immune Response in Mice. Int J Mol Sci. 2025 Oct 7;26(19)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory