About   Help   FAQ
Mapk7
Gene Detail
 Symbol
Name
ID
Mapk7
mitogen-activated protein kinase 7
MGI:1346347
Synonyms big MAP kinase 1, BMK1, ERK5, Erk5-T
Feature Type protein coding gene
Genetic Map
Chromosome 11
37.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:61488812-61494406 bp, - strand
From VEGA annotation of GRCm38

  5595 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2060  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Mapk7

Human
homologs
Human Homolog MAPK7, mitogen-activated protein kinase 7
NCBI Gene ID 5598
neXtProt AC  NX_Q13164
Human Synonyms  BMK1, ERK4, ERK5, PRKM7
Human Chr (Location)  17p11.2; chr17:19377721-19383544 (+)  GRCh38
Alleles
and
phenotypes
All alleles(10) : Targeted(9) Gene trapped(1)
 
Homozygous inactivation of this gene leads to embryonic growth retardation and midgestational lethality due to multiple developmental anomalies and vascular remodelling, cardiac development, and placental defects.
 
Phenotype Images(13)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process cell cycle, cell differentiation, ...
Component cytoplasm, cytosol, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (93)    Tissues (34)    Images (29)
Theiler Stages: 2, 3, 4, 5, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 66
Western blot 10
RT-PCR 13
cDNA source data(73)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(76) cDNA(74) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005833 (Evidence)
Ensembl Gene ModelENSMUSG00000001034 (Evidence)
Entrez Gene23939 (Evidence)
UniGene38172
DFCITC1578918, TC1590947, TC1595260, TC1596123, TC1597101, TC1607459, TC1616479, TC1723235
NIA Mouse Gene IndexU032885
EC2.7.11.24
Consensus CDS ProjectCCDS24814.1
International Mouse Knockout Project StatusMapk7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005833 VEGA Gene Model | MGI Sequence Detail 5595 C57BL/6J ±  kb
transcript OTTMUST00000012963 VEGA | MGI Sequence Detail 3019 Not Applicable 
polypeptide OTTMUSP00000006027 VEGA | MGI Sequence Detail 806 Not Applicable 

For the selected sequences
All sequences(100) RefSeq(28) UniProt(2)
Polymorphisms SNPs within 2kb(20 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003527 Mitogen-activated protein (MAP) kinase, conserved site
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000010159 mitogen-activated protein kinase 7
References (Earliest) J:57565 Kamakura S, et al., Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus. J Biol Chem. 1999 Sep 10;274(37):26563-71
(Latest) J:200879 Li T, et al., Targeted deletion of the ERK5 MAP kinase impairs neuronal differentiation, migration, and survival during adult neurogenesis in the olfactory bulb. PLoS One. 2013;8(4):e61948
All references(68)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/15/2014
MGI 5.17
The Jackson Laboratory