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Mapk7
Gene Detail
Symbol

Name
ID
Mapk7
mitogen-activated protein kinase 7
MGI:1346347
Synonyms
big MAP kinase 1, BMK1, ERK5, Erk5-T
Feature Type
protein coding gene
Genetic Map
Chromosome 11
37.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:61488812-61494406 bp, - strand
From VEGA annotation of GRCm38

  5595 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2060  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Mapk7

Human
homologs
Human Homolog MAPK7, mitogen-activated protein kinase 7
NCBI Gene ID 5598
neXtProt AC  NX_Q13164
Human Synonyms  BMK1, ERK4, ERK5, PRKM7
Human Chr (Location)  17p11.2; chr17:19377721-19383544 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(1) Targeted(9)
Incidental mutations (data from APF )
 
Homozygous inactivation of this gene leads to embryonic growth retardation and midgestational lethality due to multiple developmental anomalies and vascular remodelling, cardiac development, and placental defects.
 
Phenotype Images(13)
Interactions
Mapk7 interacts with 64 markers (Mir24-1, Mir24-2, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process cell cycle, cell differentiation, ...
Component cytoplasm, cytosol, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (90)    Tissues (32)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 66
Western blot 10
RT-PCR 10
cDNA source data(73)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(76) cDNA(74) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005833 (Evidence)
Ensembl Gene ModelENSMUSG00000001034 (Evidence)
Entrez Gene23939 (Evidence)
UniGene38172
DFCITC1723235, TC1616479, TC1578918, TC1590947, TC1607459, TC1597101, TC1595260, TC1596123
NIA Mouse Gene IndexU032885
EC2.7.11.24
Consensus CDS ProjectCCDS24814.1, CCDS70205.1
International Mouse Knockout Project StatusMapk7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005833 VEGA Gene Model | MGI Sequence Detail 5595 C57BL/6J ±  kb
transcript OTTMUST00000012963 VEGA | MGI Sequence Detail 3019 Not Applicable 
polypeptide OTTMUSP00000006027 VEGA | MGI Sequence Detail 806 Not Applicable 

For the selected sequences
All sequences(105) RefSeq(28) UniProt(7)
Polymorphisms
SNPs within 2kb(20 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003527 Mitogen-activated protein (MAP) kinase, conserved site
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000010159 mitogen-activated protein kinase 7
References
(Earliest) J:57565 Kamakura S, et al., Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus. J Biol Chem. 1999 Sep 10;274(37):26563-71
(Latest) J:209500 Zhu H, et al., Role of extracellular signal-regulated kinase 5 in adipocyte signaling. J Biol Chem. 2014 Feb 28;289(9):6311-22
All references(74)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory