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Nr0b2
Gene Detail
 Symbol
Name
ID
Nr0b2
nuclear receptor subfamily 0, group B, member 2
MGI:1346344
Synonyms SHP, SHP-1, small heterodimer partner
Feature Type protein coding gene
Genetic Map
Chromosome 4
66.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:133553376-133556536 bp, + strand
From VEGA annotation of GRCm38

  3161 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8030  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Nr0b2

Human
homologs
Human Homolog NR0B2, nuclear receptor subfamily 0, group B, member 2
NCBI Gene ID 8431
neXtProt AC  NX_Q15466
Human Synonyms  SHP, SHP1
Human Chr (Location)  1p36.1; chr1:26911484-26914076 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human NR0B2
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(4) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation are viable and fertile and exhibit no major defects in cholesterol metabolism under normal conditions. Under high cholesterol and cholic acid or iodine-deficient diets, mice exhibit decreased lipid levels.
 
Interactions
Nr0b2 interacts with 39 markers (Mir22, Mir27a, Mir32, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process negative regulation of sequence-specific DNA binding transcription factor activity, negative regulation of transcription, DNA-templated, ...
Component cytoplasm, nucleus, ...
Function DNA binding, peroxisome proliferator activated receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (160)    Tissues (144)    Images (20)
Theiler Stages: 17, 18, 21, 22, 23, 27, 28
Assay TypeResults
RNA in situ 160
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(19) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000011155 (Evidence)
Ensembl Gene ModelENSMUSG00000037583 (Evidence)
Entrez Gene23957 (Evidence)
UniGene346759
DFCITC1586127
DoTSDT.40140759
NIA Mouse Gene IndexU004919
PDB1YMT, 4NUF
Consensus CDS ProjectCCDS18751.1
International Mouse Knockout Project StatusNr0b2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011155 VEGA Gene Model | MGI Sequence Detail 3161 C57BL/6J ±  kb
transcript OTTMUST00000026136 VEGA | MGI Sequence Detail 1132 Not Applicable 
polypeptide OTTMUSP00000011961 VEGA | MGI Sequence Detail 260 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(108 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR001723 Steroid hormone receptor
Protein Ontology PR:000011391 nuclear receptor subfamily 0 group B member 2
References (Earliest) J:33440 Seol W, et al., An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors. Science. 1996 May 31;272(5266):1336-9
(Latest) J:210117 Smalling RL, et al., Genome-wide transcriptome analysis identifies novel gene signatures implicated in human chronic liver disease. Am J Physiol Gastrointest Liver Physiol. 2013 Sep 1;305(5):G364-74
All references(90)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory