Nr0b2
Gene Detail

Symbol Name ID

Nr0b2 nuclear receptor subfamily 0, group B, member 2 MGI:1346344

Synonyms

SHP, SHP-1, small heterodimer partner

Feature Type

protein coding gene

Genetic Map

Chromosome 4

66.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr4:133553376-133556536 bp, + strand From VEGA annotation of GRCm38   3161 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8030  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Nr0b2

Human homologs

Human Homolog		NR0B2, nuclear receptor subfamily 0, group B, member 2
NCBI Gene ID		8431
neXtProt AC		NX_Q15466
Human Synonyms		SHP, SHP1
Human Chr (Location)		1p36.1; chr1:27237975-27240567 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human NR0B2

Alleles and phenotypes

All alleles(10) : Targeted(6) Gene trapped(4)
 

Mice homozygous for a targeted null mutation are viable and fertile and exhibit no major defects in cholesterol metabolism under normal conditions. Under high cholesterol and cholic acid or iodine-deficient diets, mice exhibit decreased lipid levels.

 

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	negative regulation of sequence-specific DNA binding transcription factor activity, negative regulation of transcription, DNA-dependent, ...
Component	cytoplasm, nucleus, ...
Function	DNA binding, peroxisome proliferator activated receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (184)    Tissues (147)    Images (22)
Theiler Stages: 17, 18, 21, 22, 23, 28

Assay Type	Results
RNA in situ	184

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) cDNA(20) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000011155 (Evidence)
Ensembl Gene Model	ENSMUSG00000037583 (Evidence)
Entrez Gene	23957 (Evidence)
UniGene	346759
DFCI	TC1586127
DoTS	DT.40140759
NIA Mouse Gene Index	U004919
PDB	1YMT
Consensus CDS Project	CCDS18751.1
International Mouse Knockout Project Status	Nr0b2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000011155	VEGA Gene Model | MGI Sequence Detail	3161	C57BL/6J
transcript	OTTMUST00000026136	VEGA | MGI Sequence Detail	1132	Not Applicable
polypeptide	OTTMUSP00000011961	VEGA | MGI Sequence Detail	260	Not Applicable

All sequences(21) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(73 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008946	Nuclear hormone receptor, ligand-binding
InterPro	IPR000536	Nuclear hormone receptor, ligand-binding, core
InterPro	IPR001723	Steroid hormone receptor
Protein Ontology	PR:000011391	nuclear receptor subfamily 0 group B member 2

References

(Earliest) J:33440 Seol W, et al., An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors. Science. 1996 May 31;272(5266):1336-9
(Latest) J:185170 Mauldin IS, et al., The tyrosine phosphatase SHP-1 dampens murine Th17 development. Blood. 2012 May 10;119(19):4419-29
All references(85)