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Nr0b2
Gene Detail
Symbol

Name
ID
Nr0b2
nuclear receptor subfamily 0, group B, member 2
MGI:1346344
Synonyms
SHP, SHP-1, small heterodimer partner
Feature Type
protein coding gene
Genetic Map
Chromosome 4
66.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:133553376-133556536 bp, + strand
From VEGA annotation of GRCm38

  3161 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8030  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NR0B2
Gene Tree: Nr0b2

Human
homologs
NR0B2, nuclear receptor subfamily 0, group B, member 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8431
neXtProt AC: NX_Q15466

Human Synonyms: SHP, SHP1

Human Chr (Location): 1p36.1; chr1:26911484-26914076 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human NR0B2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(4) Targeted(7)
Genomic Mutations involving Nr0b2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation are viable and fertile and exhibit no major defects in cholesterol metabolism under normal conditions. Under high cholesterol and cholic acid or iodine-deficient diets, mice exhibit decreased lipid levels.
 
Interactions
Nr0b2 interacts with 39 markers (Mir22, Mir27a, Mir32, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (13 records)
Data Summary: Results (160)    Tissues (145)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 160
cDNA source data(19)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nr0b2 ; ZFIN nr0b2a, nr0b2b    NEW 
Molecular
reagents
All nucleic(20) cDNA(19) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000011155 (Evidence)
Ensembl Gene Model ENSMUSG00000037583 (Evidence)
Entrez Gene 23957 (Evidence)
UniGene 346759
DFCI TC1586127
DoTS DT.40140759
NIA Mouse Gene Index U004919
PDB 1YMT, 4NUF
Consensus CDS Project CCDS18751.1
International Mouse Phenotyping Consortium Status Nr0b2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011155 VEGA Gene Model | MGI Sequence Detail 3161 C57BL/6J ±  kb
transcript OTTMUST00000026136 VEGA | MGI Sequence Detail 1132 Not Applicable 
polypeptide OTTMUSP00000011961 VEGA | MGI Sequence Detail 260 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(108 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR001723 Steroid hormone receptor
Protein Ontology PR:000011391 nuclear receptor subfamily 0 group B member 2
References
(Earliest) J:33440 Seol W, et al., An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors. Science. 1996 May 31;272(5266):1336-9
(Latest) J:221362 Yang CS, et al., Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome. Nat Commun. 2015;6:6115
All references(94)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory