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Trex2 Gene Detail
Summary
  • Symbol
    Trex2
  • Name
    three prime repair exonuclease 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346343
    NCBI Gene: 24102
  • Gene Overview
    MyGene.info: TREX2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:73433705-73435343 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 37.31 cM, cytoband A6
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    25 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346343
protein coding gene ChrX:73433705-73435344 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035809
protein coding gene ChrX:69181195-69182834 (-)
A/J MGP_AJ_G0035790
protein coding gene ChrX:69396544-69398183 (-)
AKR/J MGP_AKRJ_G0035715
protein coding gene ChrX:71206148-71207787 (-)
BALB/cJ MGP_BALBcJ_G0035775
protein coding gene ChrX:68431599-68433238 (-)
C3H/HeJ MGP_C3HHeJ_G0035480
protein coding gene ChrX:69661528-69663167 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036305
protein coding gene ChrX:71319930-71321569 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033149
protein coding gene ChrX:68443359-68444989 (-)
CAST/EiJ MGP_CASTEiJ_G0034771
protein coding gene ChrX:55011818-55013464 (-)
CBA/J MGP_CBAJ_G0035455
protein coding gene ChrX:73258759-73260398 (-)
DBA/2J MGP_DBA2J_G0035612
protein coding gene ChrX:68864332-68865971 (-)
FVB/NJ MGP_FVBNJ_G0035556
protein coding gene ChrX:68190848-68192487 (-)
LP/J MGP_LPJ_G0035697
protein coding gene ChrX:69988793-69990432 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035594
protein coding gene ChrX:75855277-75856916 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036327
protein coding gene ChrX:69010498-69012137 (-)
PWK/PhJ MGP_PWKPhJ_G0034470
protein coding gene ChrX:53032394-53034040 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034304
protein coding gene ChrX:55930642-55932278 (-)
WSB/EiJ MGP_WSBEiJ_G0034912
protein coding gene ChrX:68288064-68289703 (-)



Homology
more
  • Human Ortholog
    TREX2, three prime repair exonuclease 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TREX2, three prime repair exonuclease 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 11219
    neXtProt AC: NX_Q9BQ50
    UniProt: Q9BQ50

  • Chr Location
    Xq28; chrX:153444720-153446487 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to DMBA- or DMBA plus TPA-induced skin tumors associated with decreased apoptosis in treated epidermis and keratinocytes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 24102 NCBI Gene Model | MGI Sequence Detail 1639 C57BL/6J ±  kb
transcript NM_011907 RefSeq | MGI Sequence Detail 1034 C57BL/6  
polypeptide Q9R1A9 UniProt | EBI | MGI Sequence Detail 236 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 3
References
more
  • Summaries
    All 26
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 3
  • Earliest
    J:56273 Mazur DJ, et al., Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases. J Biol Chem. 1999 Jul 9;274(28):19655-60
  • Latest
    J:238143 Manils J, et al., The Exonuclease Trex2 Shapes Psoriatic Phenotype. J Invest Dermatol. 2016 Dec;136(12):2345-2355

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory