Rnf13 MGI Mouse Gene Detail - MGI:1346341

Symbol

Rnf13
Name

ring finger protein 13
Synonyms

2010001H16Rik, Rzf

Feature Type

protein coding gene
IDs

MGI:1346341
NCBI Gene: 24017
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr3:57643483-57742654 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 28.04 cM
Mapping Data

3 experiments

SNPs within 2kb

531 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346341	protein coding gene	Chr3:57643468-57742846 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027232	protein coding gene	Chr3:56526119-56630993 (+)
A/J	MGP_AJ_G0027192	protein coding gene	Chr3:54787475-54890935 (+)
AKR/J	MGP_AKRJ_G0027162	protein coding gene	Chr3:55916314-56017317 (+)
BALB/cJ	MGP_BALBcJ_G0027205	protein coding gene	Chr3:54609311-54710094 (+)
C3H/HeJ	MGP_C3HHeJ_G0026948	protein coding gene	Chr3:56121312-56228533 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027651	protein coding gene	Chr3:58633216-58740863 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0026400	protein coding gene	Chr3:56280781-56392204 (+)
CBA/J	MGP_CBAJ_G0026924	protein coding gene	Chr3:60570891-60686933 (+)
DBA/2J	MGP_DBA2J_G0027058	protein coding gene	Chr3:54289724-54390739 (+)
FVB/NJ	MGP_FVBNJ_G0027026	protein coding gene	Chr3:53265049-53359174 (+)
LP/J	MGP_LPJ_G0027170	protein coding gene	Chr3:57270248-57391708 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027044	protein coding gene	Chr3:64674032-64796947 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027709	protein coding gene	Chr3:55862037-55974099 (+)
PWK/PhJ	MGP_PWKPhJ_G0026132	protein coding gene	Chr3:53934873-54036790 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025945	protein coding gene	Chr3:55533829-55640446 (+)
WSB/EiJ	MGP_WSBEiJ_G0026474	protein coding gene	Chr3:55940775-56045970 (+)

Human Ortholog

RNF13, ring finger protein 13

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RNF13, ring finger protein 13
Synonyms

DEE73, EIEE73, RZF
Links

HGNC:10057

NCBI Gene ID: 11342

neXtProt AC: NX_O43567

UniProt: O43567
Chr Location

3q25.1; chr3:149812688-149962139 (+) GRCh38

MGI Vertebrate Homology

Rnf13 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RNF13
Gene Tree

Rnf13

Diseases

1 with human RNF13 associations

				Human Disease	Mouse Models
				developmental and epileptic encephalopathy 73 IDs developmental and epileptic encephalopathy 73 DOID:0112209 OMIM:618379

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Endonuclease-mediated

3
Gene trapped

17
Radiation induced

1
Targeted

4
Genomic Mutations

1 involving Rnf13
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

37 strains or lines available

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All GO Annotations

26
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

830
Tissues

85
cDNA Data

17
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rnf13

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All Sequences

79
RefSeq

15
UniProt

9
CCDS

CCDS50913.1, CCDS79910.1, CCDS84622.1, CCDS84623.1

Ensembl

ENSMUSG00000036503 (Evidence)
NCBI Gene

24017

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036503	Ensembl Gene Model \| MGI Sequence Detail	99172	C57BL/6J	± kb
transcript	ENSMUST00000041826	Ensembl \| MGI Sequence Detail	2678	Not Applicable
polypeptide	ENSMUSP00000049331	Ensembl \| MGI Sequence Detail	381	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000014080 E3 ubiquitin-protein ligase RNF13

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR003137 PA domain

IPR046450 PA domain superfamily

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

IPR044744 ZNRF4 /RNF13/RNF167, PA domain

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All nucleic 22

cDNA 21

Primer pair 1

Microarray probesets 6

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MGI:1917075

Summaries

All 51

Developmental Gene Expression 5

Diseases 1

Gene Ontology 7

Phenotypes 15
Earliest

J:41296 Lomax MI, The gene for a RING zinc finger protein is expressed in the chick inner ear after noise exposure. Prim Sens Neuron. 1998;2(4):305-315
Latest

J:344667 Lin Z, et al., RING finger protein 13 protects against nonalcoholic steatohepatitis by targeting STING-relayed signaling pathways. Nat Commun. 2023 Oct 20;14(1):6635

TSS for Rnf13:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29188	Chr3:57643477-57643549 (+)	30 bp
Tssr29189	Chr3:57686874-57686889 (+)	43,399 bp
Tssr29190	Chr3:57703618-57703638 (+)	60,145 bp
Tssr29191	Chr3:57714438-57714452 (+)	70,962 bp
Tssr29192	Chr3:57741273-57741303 (+)	97,805 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23