Mta2
Gene Detail

Symbol Name ID

Mta2 metastasis-associated gene family, member 2 MGI:1346340

Synonyms

mmta2, Mta1l1

Feature Type

protein coding gene

Genetic Map

Chromosome 19

6.04 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr19:8941875-8952303 bp, + strand From VEGA annotation of GRCm38   10429 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3480  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Mta2

Human homologs

Human Homolog		MTA2, metastasis associated 1 family, member 2
NCBI Gene ID		9219
neXtProt AC		NX_O94776
Human Synonyms		MTA1L1, PID
Human Chr (Location)		11q12-q13.1; chr11:62360675-62369312 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(19) : Targeted(8) Gene trapped(11)
 

Mice homozygous for a null allele exhibit partial embryonic and perinatal lethality, reduced weight, shortened lifespan, and increased susceptibility to systemic lupus erythematosus with increased T cell proliferation under Th2 conditions.

 
Human Diseases Modeled Using Mouse Mta2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (34 annotations)

Process	chromatin remodeling, DNA methylation, ...
Component	histone deacetylase complex, nucleus, ...
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (89)    Tissues (80)    Images (3)
Theiler Stages: 2, 3, 4, 5, 15, 16, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	74
RT-PCR	15

cDNA source data(206)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(209) Genomic(1) cDNA(207) Primer pair(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000017291 (Evidence)
Ensembl Gene Model	ENSMUSG00000071646 (Evidence)
Entrez Gene	23942 (Evidence)
UniGene	25339
DFCI	TC1573193, TC1721839
NIA Mouse Gene Index	U019136
Consensus CDS Project	CCDS29561.1
International Mouse Knockout Project Status	Mta2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017291	VEGA Gene Model | MGI Sequence Detail	10429	C57BL/6J
transcript	OTTMUST00000041924	VEGA | MGI Sequence Detail	3135	Not Applicable
polypeptide	OTTMUSP00000018855	VEGA | MGI Sequence Detail	668	Not Applicable

All sequences(86) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(62 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001025	Bromo adjacent homology (BAH) domain
InterPro	IPR000949	ELM2 domain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR017884	SANT domain
InterPro	IPR001005	SANT/Myb domain
InterPro	IPR000679	Zinc finger, GATA-type
Protein Ontology	PR:000010708	metastasis-associated protein MTA2

References

(Earliest) J:56739 Zhang Y, et al., Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev. 1999 Aug 1;13(15):1924-35
(Latest) J:182157 Baranek C, et al., Protooncogene Ski cooperates with the chromatin-remodeling factor Satb2 in specifying callosal neurons. Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3546-51
All references(49)

Other accession IDs

MGI:2147745