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Mta2
Gene Detail
Symbol

Name
ID
Mta2
metastasis-associated gene family, member 2
MGI:1346340
Synonyms
mmta2, Mta1l1
Feature Type
protein coding gene
Genetic Map
Chromosome 19
6.04 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:8941875-8952303 bp, + strand
From VEGA annotation of GRCm38

  10429 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3480  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Mta2

Human
homologs
Human Homolog MTA2, metastasis associated 1 family, member 2
NCBI Gene ID 9219
neXtProt AC  NX_O94776
Human Synonyms  MTA1L1, PID
Human Chr (Location)  11q12-q13.1; chr11:62593203-62601840 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(11) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit partial embryonic and perinatal lethality, reduced weight, shortened lifespan, and increased susceptibility to systemic lupus erythematosus with increased T cell proliferation under Th2 conditions.
 
Human Diseases Modeled Using Mouse Mta2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Mta2 interacts with 116 markers (Mir10a, Mir16-2, Mir28b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process ATP-dependent chromatin remodeling, chromatin remodeling, ...
Component histone deacetylase complex, membrane, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (82)    Tissues (77)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 74
RT-PCR 8
cDNA source data(207)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(210) Genomic(1) cDNA(208) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000017291 (Evidence)
Ensembl Gene ModelENSMUSG00000071646 (Evidence)
Entrez Gene23942 (Evidence)
UniGene25339
DFCITC1573193, TC1721839
NIA Mouse Gene IndexU019136
Consensus CDS ProjectCCDS29561.1
International Mouse Knockout Project StatusMta2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017291 VEGA Gene Model | MGI Sequence Detail 10429 C57BL/6J ±  kb
transcript OTTMUST00000041924 VEGA | MGI Sequence Detail 3135 Not Applicable 
polypeptide OTTMUSP00000018855 VEGA | MGI Sequence Detail 668 Not Applicable 

For the selected sequences
All sequences(92) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(75 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001025 Bromo adjacent homology (BAH) domain
InterPro IPR000949 ELM2 domain
InterPro IPR009057 Homeodomain-like
InterPro IPR017884 SANT domain
InterPro IPR001005 SANT/Myb domain
InterPro IPR000679 Zinc finger, GATA-type
Protein Ontology PR:000010708 metastasis-associated protein MTA2
References
(Earliest) J:56739 Zhang Y, et al., Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev. 1999 Aug 1;13(15):1924-35
(Latest) J:194303 D R D, et al., Mi-2/NuRD is required in renal progenitor cells during embryonic kidney development. Dev Biol. 2013 Mar 15;375(2):105-16
All references(51)
Disease annotation references (1)
Other
accession IDs
MGI:2147745

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory