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Mta2 Gene Detail
Summary
  • Symbol
    Mta2
  • Name
    metastasis-associated gene family, member 2
  • Synonyms
    mmta2, Mta1l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346340
    NCBI Gene: 23942
  • Gene Overview
    MyGene.info: MTA2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr19:8941875-8952303 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10429 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 6.04 cM, cytoband B
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MTA2, metastasis associated 1 family member 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MTA2, metastasis associated 1 family member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MTA1L1, PID
  • Links
    NCBI Gene ID: 9219
    neXtProt AC: NX_O94776
    UniProt: O94776

  • Chr Location
    11q12.3; chr11:62593203-62601840 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Mta2 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit partial embryonic and perinatal lethality, reduced weight, shortened lifespan, and increased susceptibility to systemic lupus erythematosus with increased T cell proliferation under Th2 conditions.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000017291 VEGA Gene Model | MGI Sequence Detail 10429 C57BL/6J ±  kb
    transcript OTTMUST00000041924 VEGA | MGI Sequence Detail 3135 Not Applicable  
    polypeptide OTTMUSP00000018855 VEGA | MGI Sequence Detail 668 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      73 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 211
      Genomic 1
      cDNA 209
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2147745
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 18
      Phenotypes 8
    • Earliest
      J:56739 Zhang Y, et al., Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev. 1999 Aug 1;13(15):1924-35
    • Latest
      J:240892 Nitarska J, et al., A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development. Cell Rep. 2016 Nov 01;17(6):1683-1698

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory