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Mta2 Gene Detail
Summary
  • Symbol
    Mta2
  • Name
    metastasis-associated gene family, member 2
  • Synonyms
    mmta2, Mta1l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346340
    NCBI Gene: 23942
Location & Maps
more
  • Sequence Map
    Chr19:8941875-8952303 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10429 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MTA2, metastasis associated 1 family member 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MTA2, metastasis associated 1 family member 2
    Orthology source: HomoloGene
  • Synonyms
    MTA1L1, PID
  • Links
    NCBI Gene ID: 9219
    neXtProt AC: NX_O94776

  • Chr Location
    11q12-q13.1; chr11:62593203-62601840 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Mta2 mouse models

Human Disease Mouse Models
       Systemic Lupus Erythematosus; SLE   OMIM: 152700 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    19
  • Gene trapped
    11
  • Targeted
    8
  • Incidental Mutations
Mice homozygous for a null allele exhibit partial embryonic and perinatal lethality, reduced weight, shortened lifespan, and increased susceptibility to systemic lupus erythematosus with increased T cell proliferation under Th2 conditions.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017291 VEGA Gene Model | MGI Sequence Detail 10429 C57BL/6J ±  kb
transcript OTTMUST00000041924 VEGA | MGI Sequence Detail 3135 Not Applicable  
polypeptide OTTMUSP00000018855 VEGA | MGI Sequence Detail 668 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    75 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 210
    Genomic 1
    cDNA 208
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:2147745
References
more
  • Summaries
    All 49
    Developmental Gene Expression 8
    Diseases 1
    Gene Ontology 15
    Phenotypes 8
  • Earliest
    J:56739 Zhang Y, et al., Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev. 1999 Aug 1;13(15):1924-35
  • Latest
    J:194303 D R D, et al., Mi-2/NuRD is required in renal progenitor cells during embryonic kidney development. Dev Biol. 2013 Mar 15;375(2):105-16

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory