Xcr1
Gene Detail

Symbol Name ID

Xcr1 chemokine (C motif) receptor 1 MGI:1346338

Synonyms

Ccxcr1, C motif-1/lymphotactin receptor, GPR5, XCR1

Feature Type

protein coding gene

Genetic Map

Chromosome 9

74.71 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr9:123852315-123862029 bp, - strand From NCBI annotation of GRCm38   9715 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Xcr1 ± 2 cM)

Protein SuperFamily: chemokine receptor
Gene Tree: Xcr1

Human ortholog

XCR1 chemokine (C motif) receptor 1 NCBI Gene ID 2829
Human Synonyms: CCXCR1, GPR5
Human Chr3:46062291-46068979 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for a targeted null mutation exhibit reduced CD8+ dendritic cell migration in response to XCL1.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	chemokine-mediated signaling pathway, chemotaxis, ...
Component	integral to membrane, membrane, ...
Function	chemokine receptor activity, G-protein coupled receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (149)    Tissues (94)    Images (23)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	67
In situ reporter (knock in)	47
RT-PCR	35

cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(7) cDNA(6) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000060509 (Evidence)
Entrez Gene	23832 (Evidence)
UniGene	390241
DFCI	TC1591300
DoTS	DT.91345814
NIA Mouse Gene Index	U031482
Consensus CDS Project	CCDS23665.1
International Mouse Knockout Project Status	Xcr1

Sequences

Length	Strain/Species
genomic	23832	NCBI Gene Model | MGI Sequence Detail	9715	C57BL/6J
transcript	NM_011798	RefSeq | MGI Sequence Detail	4453	C57BL/6
polypeptide	Q9R0M1	UniProt | EBI | MGI Sequence Detail	322	Not Applicable

All sequences(17) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(98 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005393	C chemokine lymphotactin receptor
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
Protein Ontology	PR:000001212	chemokine XC receptor 1

Graphical View of Protein Domain Structure

References

(Earliest) J:57566 Yoshida T, et al., Molecular cloning of mXCR1, the murine SCM-1/lymphotactin receptor. FEBS Lett. 1999 Sep 10;458(1):37-40
(Latest) J:179451 Crozat K, et al., Cutting edge: Expression of XCR1 defines mouse lymphoid-tissue resident and migratory dendritic cells of the CD8alpha+ type. J Immunol. 2011 Nov 1;187(9):4411-5
All references(31)