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Xcr1
Gene Detail
 Symbol
Name
ID
Xcr1
chemokine (C motif) receptor 1
MGI:1346338
Synonyms Ccxcr1, C motif-1/lymphotactin receptor, GPR5, XCR1
Feature Type protein coding gene
Genetic Map
Chromosome 9
74.71 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:123852315-123862029 bp, - strand
From VEGA annotation of GRCm38

  9715 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21095  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 4 zebrafish

Protein SuperFamily: chemokine receptor
Gene Tree: Xcr1

Human
homologs
Human Homolog XCR1, chemokine (C motif) receptor 1
NCBI Gene ID 2829
neXtProt AC  NX_P46094
Human Synonyms  CCXCR1, GPR5
Human Chr (Location)  3p21.3; chr3:46020799-46027487 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation exhibit reduced CD8+ dendritic cell migration in response to XCL1.
 
Interactions
Xcr1 interacts with 325 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process chemotaxis, G-protein coupled receptor signaling pathway, ...
Component cell, cytosol, ...
Function chemokine receptor activity, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (149)    Tissues (94)    Images (23)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 67
In situ reporter (knock in) 47
RT-PCR 35
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(6) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000043096 (Evidence)
Ensembl Gene ModelENSMUSG00000060509 (Evidence)
Entrez Gene23832 (Evidence)
UniGene390241
DFCITC1591300
DoTSDT.91345814
NIA Mouse Gene IndexU031482
Consensus CDS ProjectCCDS23665.2
International Mouse Knockout Project StatusXcr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043096 VEGA Gene Model | MGI Sequence Detail 9715 C57BL/6J ±  kb
transcript OTTMUST00000113091 VEGA | MGI Sequence Detail 4453 Not Applicable 
polypeptide OTTMUSP00000063318 VEGA | MGI Sequence Detail 338 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(4)
Polymorphisms SNPs within 2kb(255 from dbSNP Build 137)    SNPs within 2kb including multiple locations(261)
Protein-related
information
ResourceIDDescription
InterPro IPR000355 Chemokine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR005393 XC chemokine receptor 1
Protein Ontology PR:000001212 chemokine XC receptor 1
References (Earliest) J:57566 Yoshida T, et al., Molecular cloning of mXCR1, the murine SCM-1/lymphotactin receptor. FEBS Lett. 1999 Sep 10;458(1):37-40
(Latest) J:204851 Yamazaki C, et al., Critical roles of a dendritic cell subset expressing a chemokine receptor, XCR1. J Immunol. 2013 Jun 15;190(12):6071-82
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory