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Xcr1 Gene Detail
Summary
  • Symbol
    Xcr1
  • Name
    chemokine (C motif) receptor 1
  • Synonyms
    Ccxcr1, C motif-1/lymphotactin receptor, GPR5, XCR1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346338
    NCBI Gene: 23832
  • Gene Overview
    MyGene.info: XCR1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:123852315-123862029 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 74.71 cM, cytoband F4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    251 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346338
protein coding gene Chr9:123852315-123862029 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035485
protein coding gene Chr9:126904374-126913423 (-)
A/J MGP_AJ_G0035466
protein coding gene Chr9:122059451-122069533 (-)
AKR/J MGP_AKRJ_G0035399
protein coding gene Chr9:125324674-125336246 (-)
BALB/cJ MGP_BALBcJ_G0035462
protein coding gene Chr9:121988392-121997611 (-)
C3H/HeJ MGP_C3HHeJ_G0035169
protein coding gene Chr9:125773660-125782786 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035985
protein coding gene Chr9:130413618-130422777 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032867
protein coding gene Chr9:119166215-119173984 (-)
CAST/EiJ MGP_CASTEiJ_G0034474
protein coding gene Chr9:125825743-125835140 (-)
CBA/J MGP_CBAJ_G0035137
protein coding gene Chr9:135177861-135188430 (-)
DBA/2J MGP_DBA2J_G0035296
protein coding gene Chr9:121499930-121509296 (-)
FVB/NJ MGP_FVBNJ_G0035243
protein coding gene Chr9:120403632-120414318 (-)
LP/J MGP_LPJ_G0035375
protein coding gene Chr9:127308695-127319132 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035284
protein coding gene Chr9:135988385-135999850 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036004
protein coding gene Chr9:125794115-125804466 (-)
PWK/PhJ MGP_PWKPhJ_G0034178
protein coding gene Chr9:121959479-121969166 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034015
protein coding gene Chr9:125895393-125904366 (-)
WSB/EiJ MGP_WSBEiJ_G0034594
protein coding gene Chr9:125626598-125637204 (-)



Homology
more
  • Human Ortholog
    XCR1, X-C motif chemokine receptor 1
  • Vertebrate Orthologs
    13
  • Human Ortholog
    XCR1, X-C motif chemokine receptor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CCXCR1, GPR5
  • Links
    NCBI Gene ID: 2829
    neXtProt AC: NX_P46094
    UniProt: P46094

  • Chr Location
    3p21.31; chr3:46016990-46086803 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation exhibit reduced CD8+ dendritic cell migration in response to XCL1.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 23832 NCBI Gene Model | MGI Sequence Detail 9715 C57BL/6J ±  kb
transcript NM_011798 RefSeq | MGI Sequence Detail 4453 C57BL/6  
polypeptide NP_035928 RefSeq | MGI Sequence Detail 338 C57BL/6  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR005393 XC chemokine receptor 1
Molecular
Reagents
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  • All nucleic 8
    cDNA 7
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Developmental Gene Expression 3
    Gene Ontology 2
    Phenotypes 11
  • Earliest
    J:57566 Yoshida T, et al., Molecular cloning of mXCR1, the murine SCM-1/lymphotactin receptor. FEBS Lett. 1999 Sep 10;458(1):37-40
  • Latest
    J:265115 Yamasaki S, et al., In vivo dendritic cell targeting cellular vaccine induces CD4(+) Tfh cell-dependent antibody against influenza virus. Sci Rep. 2016 Oct 14;6:35173

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory