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Klk7
Gene Detail
Symbol

Name
ID
Klk7
kallikrein related-peptidase 7 (chymotryptic, stratum corneum)
MGI:1346336
Synonyms
Prss6
Feature Type
protein coding gene
Genetic Map
Chromosome 7
28.27 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:43811444-43816359 bp, + strand
From NCBI annotation of GRCm38

  4916 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37998  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: KLK7
Protein SuperFamily: trypsin
Gene Tree: Klk7

Human
homologs
KLK7, kallikrein-related peptidase 7
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 5650
neXtProt AC: NX_P49862

Human Synonyms: hK7, PRSS6, SCCE

Human Chr (Location): 19q13.41; chr19:50976479-50984064 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(1) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
Mutations Annotated to Human Diseases (1)   
Interactions
Klk7 interacts with 119 markers (Mir7b, Mir23a, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process proteolysis
Component epidermal lamellar body, extracellular region
Function hydrolase activity, peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (220)    Tissues (28)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 217
RT-PCR 3
cDNA source data(25)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) cDNA(25) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000030713 (Evidence)
Entrez Gene 23993 (Evidence)
UniGene 251227
DFCI TC1582136
DoTS DT.533298
NIA Mouse Gene Index U008022
EC 3.4.21.117
Consensus CDS Project CCDS21183.1
International Mouse Phenotyping Consortium Status Klk7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 23993 NCBI Gene Model | MGI Sequence Detail 4916 C57BL/6J ±  kb
transcript NM_011872 RefSeq | MGI Sequence Detail 1745 C57BL/6 
polypeptide Q91VE3 UniProt | EBI | MGI Sequence Detail 249 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(112 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000009417 kallikrein-7
Graphical View of Protein Domain Structure
References
(Earliest) J:56742 Backman A, et al., Molecular cloning and tissue expression of the murine analog to human stratum corneum chymotryptic enzyme. J Invest Dermatol. 1999 Aug;113(2):152-5
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory