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Tekt2 Gene Detail
Summary
  • Symbol
    Tekt2
  • Name
    tektin 2
  • Synonyms
    tektin-t
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346335
    NCBI Gene: 24084
Location & Maps
more
  • Sequence Map
    Chr4:126322121-126325688 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3568 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 60.37 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TEKT2, tektin 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TEKT2, tektin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    h-tektin-t, TEKTB1, TEKTIN-T
  • Links
    NCBI Gene ID: 27285
    neXtProt AC: NX_Q9UIF3

  • Chr Location
    1p34.3; chr1:36084075-36088276 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8043
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TEKT2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    2
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    4 involving Tekt2
  • Incidental Mutations
Mice homozygous for a gene trapped allele exhibit male infertility and impaired motility of both sperm flagella and tracheal cilia due to altered dynein inner arm morphology and function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009354 VEGA Gene Model | MGI Sequence Detail 3568 C57BL/6J ±  kb
transcript OTTMUST00000021319 VEGA | MGI Sequence Detail 1542 Not Applicable  
polypeptide OTTMUSP00000009749 VEGA | MGI Sequence Detail 430 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    31 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 5
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2140423
References
more
  • Summaries
    All 32
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 13
  • Earliest
    J:56926 Iguchi N, et al., Molecular cloning of haploid germ cell-specific tektin cDNA and analysis of the protein in mouse testis. FEBS Lett. 1999 Aug 6;456(2):315-21
  • Latest
    J:182741 Alten L, et al., Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1. Development. 2012 Apr;139(7):1276-84

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory