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Gpr34 Gene Detail
Summary
  • Symbol
    Gpr34
  • Name
    G protein-coupled receptor 34
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346334
    NCBI Gene: 23890
  • Gene Overview
    MyGene.info: GPR34
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:13632089-13640858 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 8.55 cM, cytoband A1.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    69 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346334
protein coding gene ChrX:13622650-13640859 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035574
protein coding gene ChrX:8498996-8507693 (+)
A/J MGP_AJ_G0035552
protein coding gene ChrX:8578258-8586950 (+)
AKR/J MGP_AKRJ_G0035484
protein coding gene ChrX:8870778-8879463 (+)
BALB/cJ MGP_BALBcJ_G0035545
protein coding gene ChrX:8439318-8448033 (+)
C3H/HeJ MGP_C3HHeJ_G0035261
protein coding gene ChrX:8600392-8609101 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036074
protein coding gene ChrX:8708517-8717199 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032944
protein coding gene ChrX:7477833-7486590 (+)
CAST/EiJ MGP_CASTEiJ_G0034553
protein coding gene ChrX:8347654-8356299 (+)
CBA/J MGP_CBAJ_G0035230
protein coding gene ChrX:9146884-9155578 (+)
DBA/2J MGP_DBA2J_G0035383
protein coding gene ChrX:8415844-8424340 (+)
FVB/NJ MGP_FVBNJ_G0035330
protein coding gene ChrX:8253404-8262077 (+)
LP/J MGP_LPJ_G0035465
protein coding gene ChrX:8670935-8679943 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035373
protein coding gene ChrX:9060148-9069694 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036086
protein coding gene ChrX:8414838-8423535 (+)
PWK/PhJ MGP_PWKPhJ_G0034254
protein coding gene ChrX:7905702-7914533 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034095
protein coding gene ChrX:8512822-8521554 (+)
WSB/EiJ MGP_WSBEiJ_G0034689
protein coding gene ChrX:8451381-8460063 (+)



Homology
more
  • Human Ortholog
    GPR34, G protein-coupled receptor 34
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GPR34, G protein-coupled receptor 34
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LYPSR1
  • Links
    NCBI Gene ID: 2857
    neXtProt AC: NX_Q9UPC5
    UniProt: Q9UPC5

  • Chr Location
    Xp11.4; chrX:41686543-41697277 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased monocyte migration and susceptibility to type IV hypersensitivity and fungal infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040229 Ensembl Gene Model | MGI Sequence Detail 8770 C57BL/6J ±  kb
    transcript ENSMUST00000096492 Ensembl | MGI Sequence Detail 1898 Not Applicable  
    polypeptide ENSMUSP00000094236 Ensembl | MGI Sequence Detail 375 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 34
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:56262 Schoneberg T, et al., A novel subgroup of class I G-protein-coupled receptors. Biochim Biophys Acta. 1999 Jul 7;1446(1-2):57-70
    • Latest
      J:290758 Sayo A, et al., GPR34 in spinal microglia exacerbates neuropathic pain in mice. J Neuroinflammation. 2019 Apr 11;16(1):82

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    10/13/2020
    MGI 6.16
    The Jackson Laboratory