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Gpr34 Gene Detail
Summary
  • Symbol
    Gpr34
  • Name
    G protein-coupled receptor 34
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346334
    NCBI Gene: 23890
  • Gene Overview
    MyGene.info: GPR34
Location & Maps
more
  • Sequence Map
    ChrX:13632089-13640856 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8768 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    GPR34, G protein-coupled receptor 34
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GPR34, G protein-coupled receptor 34
    Orthology source: HomoloGene
  • Synonyms
    LYPSR1
  • Links
    NCBI Gene ID: 2857
    neXtProt AC: NX_Q9UPC5

  • Chr Location
    Xp11.4; chrX:41688959-41697277 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Targeted
    5
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele exhibit increased monocyte migration and susceptibility to type IV hypersensitivity and fungal infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016906 VEGA Gene Model | MGI Sequence Detail 8768 C57BL/6J ±  kb
transcript OTTMUST00000041027 VEGA | MGI Sequence Detail 2088 Not Applicable  
polypeptide OTTMUSP00000018373 VEGA | MGI Sequence Detail 375 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    69 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000001530 G-protein coupled receptor 34
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
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  • All nucleic 15
    cDNA 13
    Primer pair 1
    Other 1

    Microarray probesets 2
References
more
  • Summaries
    All 29
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:56262 Schoneberg T, et al., A novel subgroup of class I G-protein-coupled receptors. Biochim Biophys Acta. 1999 Jul 7;1446(1-2):57-70
  • Latest
    J:222307 Barnes MJ, et al., The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function. J Exp Med. 2015 Jun 29;212(7):1011-20

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory