Gpr34 MGI Mouse Gene Detail - MGI:1346334 - G protein-coupled receptor 34

Symbol

Gpr34
Name

G protein-coupled receptor 34

Feature Type

protein coding gene
IDs

MGI:1346334
NCBI Gene: 23890
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

ChrX:13498328-13507097 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 8.55 cM, cytoband A1.3
Mapping Data

2 experiments

SNPs within 2kb

32 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346334	protein coding gene	ChrX:13489777-13507098 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035574	protein coding gene	ChrX:8498996-8507693 (+)
A/J	MGP_AJ_G0035552	protein coding gene	ChrX:8578258-8586950 (+)
AKR/J	MGP_AKRJ_G0035484	protein coding gene	ChrX:8870778-8879463 (+)
BALB/cJ	MGP_BALBcJ_G0035545	protein coding gene	ChrX:8439318-8448033 (+)
C3H/HeJ	MGP_C3HHeJ_G0035261	protein coding gene	ChrX:8600392-8609101 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036074	protein coding gene	ChrX:8708517-8717199 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032944	protein coding gene	ChrX:7477833-7486590 (+)
CAST/EiJ	MGP_CASTEiJ_G0034553	protein coding gene	ChrX:8347654-8356299 (+)
CBA/J	MGP_CBAJ_G0035230	protein coding gene	ChrX:9146884-9155578 (+)
DBA/2J	MGP_DBA2J_G0035383	protein coding gene	ChrX:8415844-8424340 (+)
FVB/NJ	MGP_FVBNJ_G0035330	protein coding gene	ChrX:8253404-8262077 (+)
LP/J	MGP_LPJ_G0035465	protein coding gene	ChrX:8670935-8679943 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035373	protein coding gene	ChrX:9060148-9069694 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036086	protein coding gene	ChrX:8414838-8423535 (+)
PWK/PhJ	MGP_PWKPhJ_G0034254	protein coding gene	ChrX:7905702-7914533 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034095	protein coding gene	ChrX:8512822-8521554 (+)
WSB/EiJ	MGP_WSBEiJ_G0034689	protein coding gene	ChrX:8451381-8460063 (+)

Human Ortholog

GPR34, G protein-coupled receptor 34

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPR34, G protein-coupled receptor 34
Synonyms

LPS1, LYPSR1
Links

HGNC:4490

NCBI Gene ID: 2857

neXtProt AC: NX_Q9UPC5

UniProt: Q9UPC5
Chr Location

Xp11.4; chrX:41688973-41697275 (+) GRCh38

MGI Vertebrate Homology

Gpr34 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GPR34
Gene Tree

Gpr34

less

Phenotype Summary

15 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

4
Targeted

5
Incidental Mutations

APF
Find Mice (IMSR)

7 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased monocyte migration and susceptibility to type IV hypersensitivity and fungal infection.

less

All GO Annotations

4
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

735
Tissues

20
cDNA Data

14
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gpr34

ZFIN gpr34a, gpr34b

less

All Sequences

47
RefSeq

8
UniProt

5
CCDS

CCDS30028.1

Ensembl

ENSMUSG00000040229 (Evidence)
NCBI Gene

23890

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040229	Ensembl Gene Model \| MGI Sequence Detail	8770	C57BL/6J	± kb
transcript	ENSMUST00000041708	Ensembl \| MGI Sequence Detail	2088	Not Applicable
polypeptide	ENSMUSP00000042715	Ensembl \| MGI Sequence Detail	375	Not Applicable

less

UniProt

5 Sequences
Protein Ontology

PR:000001530 probable G-protein coupled receptor 34

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR048057 Probable G protein-coupled receptor 34, 7TM

less

All nucleic 16

cDNA 14

Primer pair 2

Microarray probesets 2

Summaries

All 39

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 11
Earliest

J:56262 Schoneberg T, et al., A novel subgroup of class I G-protein-coupled receptors. Biochim Biophys Acta. 1999 Jul 7;1446(1-2):57-70
Latest

J:321301 Wang X, et al., GPR34-mediated sensing of lysophosphatidylserine released by apoptotic neutrophils activates type 3 innate lymphoid cells to mediate tissue repair. Immunity. 2021 Jun 8;54(6):1123-1136.e8

TSS for Gpr34:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr160604	ChrX:13498321-13498375 (+)	20 bp
Tssr160605	ChrX:13499019-13499037 (+)	700 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23