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Uts2 Gene Detail
Summary
  • Symbol
    Uts2
  • Name
    urotensin 2
  • Synonyms
    prepro-UII, Ucn2, urotensin II precursor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346329
    NCBI Gene: 24111
  • Gene Overview
    MyGene.info: UTS2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:150997097-151001810 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 81.53 cM, cytoband E1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    120 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346329
protein coding gene Chr4:150997097-151001810 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029160
protein coding gene Chr4:155026220-155031032 (+)
A/J MGP_AJ_G0029125
protein coding gene Chr4:148507442-148512155 (+)
AKR/J MGP_AKRJ_G0029073
protein coding gene Chr4:152576122-152580848 (+)
BALB/cJ MGP_BALBcJ_G0029141
protein coding gene Chr4:149001592-149006305 (+)
C3H/HeJ MGP_C3HHeJ_G0028862
protein coding gene Chr4:153144781-153149498 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029590
protein coding gene Chr4:160594922-160599635 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026836
protein coding gene Chr4:140888567-140893255 (+)
CAST/EiJ MGP_CASTEiJ_G0028275
protein coding gene Chr4:150423027-150427758 (+)
CBA/J MGP_CBAJ_G0028824
protein coding gene Chr4:165360367-165365789 (+)
DBA/2J MGP_DBA2J_G0028973
protein coding gene Chr4:148584722-148589440 (+)
FVB/NJ MGP_FVBNJ_G0028937
protein coding gene Chr4:147727559-147733107 (+)
LP/J MGP_LPJ_G0029063
protein coding gene Chr4:154959367-154964073 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028964
protein coding gene Chr4:168476781-168482617 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029622
protein coding gene Chr4:153102503-153108251 (+)
PWK/PhJ MGP_PWKPhJ_G0027995
protein coding gene Chr4:144620840-144625532 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027829
protein coding gene Chr4:147351558-147356231 (+)
WSB/EiJ MGP_WSBEiJ_G0028355
protein coding gene Chr4:153235269-153239984 (+)



Homology
more
  • Human Ortholog
    UTS2, urotensin 2
  • Vertebrate Orthologs
    6
  • Human Ortholog
    UTS2, urotensin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PRO1068, UCN2, UII, U-II
  • Links
    NCBI Gene ID: 10911
    neXtProt AC: NX_O95399
    UniProt: O95399

  • Chr Location
    1p36.23; chr1:7846345-7913615 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to alterations in macrophage and hepatic cholesterol homeostasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 24111 NCBI Gene Model | MGI Sequence Detail 4714 C57BL/6J ±  kb
transcript NM_011910 RefSeq | MGI Sequence Detail 538 C57BL/6  
polypeptide Q9QZQ3 UniProt | EBI | MGI Sequence Detail 123 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 2
References
more
  • Summaries
    All 35
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:57017 Coulouarn Y, et al., Cloning, sequence analysis and tissue distribution of the mouse and rat urotensin II precursors. FEBS Lett. 1999 Aug 20;457(1):28-32
  • Latest
    J:196412 Watson AM, et al., Urotensin II receptor antagonism confers vasoprotective effects in diabetes associated atherosclerosis: studies in humans and in a mouse model of diabetes. Diabetologia. 2013 May;56(5):1155-65

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory