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Fyb
Gene Detail
Symbol

Name
ID
Fyb
FYN binding protein
MGI:1346327
Synonyms
ADAP, B630013F22Rik, FYB-120/130
Feature Type
protein coding gene
Genetic Map
Chromosome 15
3.19 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:6579871-6663313 bp, + strand
From VEGA annotation of GRCm38

  83443 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22664  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FYB
Gene Tree: Fyb

Human
homologs
FYB, FYN binding protein
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2533
neXtProt AC: NX_O15117

Human Synonyms: ADAP, PRO0823, SLAP130, SLAP-130

Human Chr (Location): 5p13.1; chr5:39105252-39274523 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(3) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit decreased T cell proliferation, thymocytes and platelet counts and decreased TCR-stimulated leukocyte adhesion.
 
Interactions
Fyb interacts with 53 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process immune response, protein localization to plasma membrane
Component actin cytoskeleton, cytoplasm, ...
Function protein binding, protein complex binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (6)    Tissues (1)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 6
cDNA source data(191)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(195) cDNA(195)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000034885 (Evidence)
Ensembl Gene Model ENSMUSG00000022148 (Evidence)
Entrez Gene 23880 (Evidence)
UniGene 170905
DFCI TC1690648, TC1589946, TC1581746
Consensus CDS Project CCDS37031.1
International Mouse Phenotyping Consortium Status Fyb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034885 VEGA Gene Model | MGI Sequence Detail 83443 C57BL/6J ±  kb
transcript OTTMUST00000088668 VEGA | MGI Sequence Detail 2669 Not Applicable 
polypeptide OTTMUSP00000048358 VEGA | MGI Sequence Detail 819 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(19) UniProt(6)
Polymorphisms
SNPs within 2kb(377 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001452 Src homology-3 domain
InterPro IPR011511 Variant SH3
Protein Ontology PR:000007717 FYN-binding protein
References
(Earliest) J:41750 da Silva AJ, et al., Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7493-8
(Latest) J:210761 Kasirer-Friede A, et al., ADAP interactions with talin and kindlin promote platelet integrin alphaIIbbeta3 activation and stable fibrinogen binding. Blood. 2014 May 15;123(20):3156-65
All references(62)
Other
accession IDs
MGI:2443545

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory