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Fyb Gene Detail
Summary
  • Symbol
    Fyb
  • Name
    FYN binding protein
  • Synonyms
    ADAP, B630013F22Rik, FYB-120/130
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346327
    NCBI Gene: 23880
  • Gene Overview
    MyGene.info: FYB
Location & Maps
more
  • Sequence Map
    Chr15:6579871-6663313 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      83443 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 3.19 cM, cytoband A1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FYB, FYN binding protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FYB, FYN binding protein
    Orthology source: HomoloGene
  • Synonyms
    ADAP, PRO0823, SLAP130, SLAP-130
  • Links
    NCBI Gene ID: 2533
    neXtProt AC: NX_O15117

  • Chr Location
    5p13.1; chr5:39105252-39274523 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 22664
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: FYB
  • Gene Tree
    Fyb
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased T cell proliferation, thymocytes and platelet counts and decreased TCR-stimulated leukocyte adhesion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034885 VEGA Gene Model | MGI Sequence Detail 83443 C57BL/6J ±  kb
transcript OTTMUST00000088668 VEGA | MGI Sequence Detail 2669 Not Applicable  
polypeptide OTTMUSP00000048358 VEGA | MGI Sequence Detail 819 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    482 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 195
    cDNA 195

    Microarray probesets 3
Other
Accession IDs
less
MGI:2443545
References
more
  • Summaries
    All 62
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 29
  • Earliest
    J:41750 da Silva AJ, et al., Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7493-8
  • Latest
    J:210761 Kasirer-Friede A, et al., ADAP interactions with talin and kindlin promote platelet integrin alphaIIbbeta3 activation and stable fibrinogen binding. Blood. 2014 May 15;123(20):3156-65

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory