About   Help   FAQ
Fyb
Gene Detail
 Symbol
Name
ID
Fyb
FYN binding protein
MGI:1346327
Synonyms ADAP, B630013F22Rik, FYB-120/130
Feature Type protein coding gene
Genetic Map
Chromosome 15
3.19 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:6579871-6663313 bp, + strand
From VEGA annotation of GRCm38

  83443 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22664  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Fyb

Human
homologs
Human Homolog FYB, FYN binding protein
NCBI Gene ID 2533
neXtProt AC  NX_O15117
Human Synonyms  ADAP, PRO0823, SLAP-130
Human Chr (Location)  5p13.1; chr5:39105252-39274523 (-)  GRCh38
Alleles
and
phenotypes
All alleles(7) : Gene trapped(3) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit decreased T cell proliferation, thymocytes and platelet counts and decreased TCR-stimulated leukocyte adhesion.
 
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Component cytoplasm, nucleus
Function protein complex binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (6)    Tissues (1)    Images (6)
Theiler Stages: 23
Assay TypeResults
RNA in situ 6
cDNA source data(191)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(195) cDNA(195)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000034885 (Evidence)
Ensembl Gene ModelENSMUSG00000022148 (Evidence)
Entrez Gene23880 (Evidence)
UniGene170905
DFCITC1581746, TC1589946, TC1690648
Consensus CDS ProjectCCDS37031.1
International Mouse Knockout Project StatusFyb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034885 VEGA Gene Model | MGI Sequence Detail 83443 C57BL/6J ±  kb
transcript OTTMUST00000088668 VEGA | MGI Sequence Detail 2669 Not Applicable 
polypeptide OTTMUSP00000048358 VEGA | MGI Sequence Detail 819 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(14) UniProt(6)
Polymorphisms SNPs within 2kb(377 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001452 Src homology-3 domain
InterPro IPR011511 Variant SH3
Protein Ontology PR:000007717 FYN-binding protein
References (Earliest) J:41750 da Silva AJ, et al., Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7493-8
(Latest) J:208208 Rajasekaran K, et al., Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells. Nat Immunol. 2013 Nov;14(11):1127-36
All references(59)
Other
accession IDs
MGI:2443545

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory