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Gadd45g
Gene Detail
Symbol

Name
ID
Gadd45g
growth arrest and DNA-damage-inducible 45 gamma
MGI:1346325
Synonyms
CR6, OIG37
Feature Type
protein coding gene
Genetic Map
Chromosome 13
26.36 cM, cytoband A5-B
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:51846678-51848468 bp, + strand
From VEGA annotation of GRCm38

  1791 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21334  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GADD45G
Protein SuperFamily: growth arrest and DNA-damage-inducible protein GADD45
Gene Tree: Gadd45g

Human
homologs
GADD45G, growth arrest and DNA-damage-inducible, gamma
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 10912
neXtProt AC: NX_O95257

Human Synonyms: CR6, DDIT2, GADD45gamma, GRP17

Human Chr (Location): 9q22.1-q22.2; chr9:89605012-89606555 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for some null alleles show male to female sex reversal. Mice homozygous for a null allele show abnormal T-helper 1 and NK physiology and decreased type IV hypersensitivity. Mice homozygous for a second null allele show altered cellular survival to osmotic stress.
 
Interactions
Gadd45g interacts with 44 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process activation of MAPKK activity, activation of MAPKKK activity, ...
Component cytoplasm, nucleus
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (213)    Tissues (143)    Images (52)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 207
RT-PCR 6
cDNA source data(63)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gadd45g ; ZFIN gadd45ga, gadd45gb.1    NEW 
Molecular
reagents
All nucleic(67) Genomic(1) cDNA(63) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000023076 (Evidence)
Ensembl Gene Model ENSMUSG00000021453 (Evidence)
Entrez Gene 23882 (Evidence)
UniGene 281298
DFCI TC1578240
DoTS DT.533434
NIA Mouse Gene Index U014847
PDB 3CG6
Consensus CDS Project CCDS26515.1
International Mouse Phenotyping Consortium Status Gadd45g
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023076 VEGA Gene Model | MGI Sequence Detail 1791 C57BL/6J ±  kb
transcript OTTMUST00000055694 VEGA | MGI Sequence Detail 1071 Not Applicable 
polypeptide OTTMUSP00000026704 VEGA | MGI Sequence Detail 159 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(1 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024824 Growth arrest and DNA damage-inducible protein GADD45
InterPro IPR004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45
Protein Ontology PR:000007789 growth arrest and DNA damage-inducible protein GADD45 gamma
References
(Earliest) J:57022 Nakayama K, et al., A novel oncostatin M-inducible gene OIG37 forms a gene family with MyD118 and GADD45 and negatively regulates cell growth. J Biol Chem. 1999 Aug 27;274(35):24766-72
(Latest) J:214032 Ishida K, et al., Gadd45g regulates dental epithelial cell proliferation through p38 MAPK-mediated p21 expression. Genes Cells. 2013 Aug;18(8):660-71
All references(63)
Other
accession IDs
MGI:2145220, MGI:2145531

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory