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Gadd45g Gene Detail
Summary
  • Symbol
    Gadd45g
  • Name
    growth arrest and DNA-damage-inducible 45 gamma
  • Synonyms
    CR6, OIG37
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346325
    NCBI Gene: 23882
  • Gene Overview
    MyGene.info: GADD45G
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:51846678-51848468 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1791 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 26.36 cM, cytoband A5-B
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    GADD45G, growth arrest and DNA damage inducible gamma
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GADD45G, growth arrest and DNA damage inducible gamma
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CR6, DDIT2, GADD45gamma, GRP17
  • Links
    NCBI Gene ID: 10912
    neXtProt AC: NX_O95257
    UniProt: O95257

  • Chr Location
    9q22.2; chr9:89605009-89606555 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 3 alleles in 5 genetic backgrounds
    15 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for some null alleles exhibit male to female sex reversal, abnormal T-helper 1 and NK physiology, decreased type IV hypersensitivity, altered cellular survival to osmotic stress and impaired adaptive thermogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000023076 VEGA Gene Model | MGI Sequence Detail 1791 C57BL/6J ±  kb
    transcript OTTMUST00000055694 VEGA | MGI Sequence Detail 1071 Not Applicable  
    polypeptide OTTMUSP00000026704 VEGA | MGI Sequence Detail 159 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • PDB
    • InterPro Domains
      IPR029064 50S ribosomal protein L30e-like
      IPR024824 Growth arrest and DNA damage-inducible protein GADD45
      IPR004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45
    Molecular
    Reagents
    less
    • All nucleic 67
      Genomic 1
      cDNA 63
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2145220, MGI:2145531
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 22
      Gene Ontology 8
      Phenotypes 19
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:250512 Li J, et al., CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice. Database (Oxford). 2017;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory