About   Help   FAQ
Gadd45g Gene Detail
Summary
  • Symbol
    Gadd45g
  • Name
    growth arrest and DNA-damage-inducible 45 gamma
  • Synonyms
    CR6, OIG37
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346325
    NCBI Gene: 23882
Location & Maps
more
  • Sequence Map
    Chr13:51846678-51848468 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1791 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    GADD45G, growth arrest and DNA damage inducible gamma
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GADD45G, growth arrest and DNA damage inducible gamma
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CR6, DDIT2, GADD45gamma, GRP17
  • Links
    NCBI Gene ID: 10912
    neXtProt AC: NX_O95257

  • Chr Location
    9q22.1-q22.2; chr9:89605012-89606555 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 5 genetic backgrounds
    14 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Gadd45g
  • Incidental Mutations
Mice homozygous for some null alleles show male to female sex reversal. Mice homozygous for a null allele show abnormal T-helper 1 and NK physiology and decreased type IV hypersensitivity. Mice homozygous for a second null allele show altered cellular survival to osmotic stress.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023076 VEGA Gene Model | MGI Sequence Detail 1791 C57BL/6J ±  kb
transcript OTTMUST00000055694 VEGA | MGI Sequence Detail 1071 Not Applicable  
polypeptide OTTMUSP00000026704 VEGA | MGI Sequence Detail 159 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1 from dbSNP Build 137
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000007789 growth arrest and DNA damage-inducible protein GADD45 gamma
  • PDB
  • InterPro Domains
    IPR029064 50S ribosomal protein L30e-like
    IPR024824 Growth arrest and DNA damage-inducible protein GADD45
    IPR004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45
Molecular
Reagents
less
  • All nucleic 67
    Genomic 1
    cDNA 63
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGI:2145220, MGI:2145531
References
more
  • Summaries
    All 64
    Developmental Gene Expression 21
    Gene Ontology 6
    Phenotypes 17
  • Earliest
    J:57022 Nakayama K, et al., A novel oncostatin M-inducible gene OIG37 forms a gene family with MyD118 and GADD45 and negatively regulates cell growth. J Biol Chem. 1999 Aug 27;274(35):24766-72
  • Latest
    J:225434 Cesario JM, et al., Lhx6 and Lhx8 promote palate development through negative regulation of a cell cycle inhibitor gene, p57Kip2. Hum Mol Genet. 2015 Sep 1;24(17):5024-39

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory