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Gadd45g Gene Detail
Summary
  • Symbol
    Gadd45g
  • Name
    growth arrest and DNA-damage-inducible 45 gamma
  • Synonyms
    CR6, OIG37
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346325
    NCBI Gene: 23882
  • Gene Overview
    MyGene.info: GADD45G
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:51846678-51848468 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 26.36 cM, cytoband A5-B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346325
protein coding gene Chr13:51846675-51848475 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020555
protein coding gene Chr13:51100470-51102260 (+)
A/J MGP_AJ_G0020509
protein coding gene Chr13:49271591-49273381 (+)
AKR/J MGP_AKRJ_G0020487
protein coding gene Chr13:50673595-50675385 (+)
BALB/cJ MGP_BALBcJ_G0020505
protein coding gene Chr13:49461689-49463479 (+)
C3H/HeJ MGP_C3HHeJ_G0020304
protein coding gene Chr13:50519579-50521369 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020939
protein coding gene Chr13:52661152-52662942 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018521
protein coding gene Chr13:47065769-47067555 (+)
CAST/EiJ MGP_CASTEiJ_G0019818
protein coding gene Chr13:50477034-50482815 (+)
CBA/J MGP_CBAJ_G0020264
protein coding gene Chr13:54713746-54715536 (+)
DBA/2J MGP_DBA2J_G0020387
protein coding gene Chr13:48838401-48840191 (+)
FVB/NJ MGP_FVBNJ_G0020366
protein coding gene Chr13:48272170-48273960 (+)
LP/J MGP_LPJ_G0020463
protein coding gene Chr13:51370229-51372019 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020395
protein coding gene Chr13:54296190-54297979 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020982
protein coding gene Chr13:50255743-50257533 (+)
PWK/PhJ MGP_PWKPhJ_G0019575
protein coding gene Chr13:48759823-48762445 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019402
protein coding gene Chr13:49146870-49149280 (+)
WSB/EiJ MGP_WSBEiJ_G0019880
protein coding gene Chr13:50585761-50587553 (+)



Homology
more
  • Human Ortholog
    GADD45G, growth arrest and DNA damage inducible gamma
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GADD45G, growth arrest and DNA damage inducible gamma
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CR6, DDIT2, GADD45gamma, GRP17
  • Links
    NCBI Gene ID: 10912
    neXtProt AC: NX_O95257
    UniProt: O95257

  • Chr Location
    9q22.2; chr9:89605009-89606555 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 3 alleles in 5 genetic backgrounds
    15 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for some null alleles exhibit male to female sex reversal, abnormal T-helper 1 and NK physiology, decreased type IV hypersensitivity, altered cellular survival to osmotic stress and impaired adaptive thermogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021453 Ensembl Gene Model | MGI Sequence Detail 1791 C57BL/6J ±  kb
    transcript ENSMUST00000021903 Ensembl | MGI Sequence Detail 1071 Not Applicable  
    polypeptide ENSMUSP00000021903 Ensembl | MGI Sequence Detail 159 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • PDB
    • InterPro Domains
      IPR029064 50S ribosomal protein L30e-like
      IPR024824 Growth arrest and DNA damage-inducible protein GADD45
      IPR004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45
    Molecular
    Reagents
    less
    • All nucleic 68
      Genomic 1
      cDNA 64
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2145220, MGI:2145531
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 23
      Gene Ontology 9
      Phenotypes 19
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:264125 Xu Z, et al., SP8 and SP9 coordinately promote D2-type medium spiny neuron production by activating Six3 expression. Development. 2018 Jul 23;145(14)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory