Gpc6
Gene Detail

Symbol Name ID

Gpc6 glypican 6 MGI:1346322

Synonyms

6720429C22Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 14

60.34 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr14:116925297-117979529 bp, + strand From VEGA annotation of GRCm38   1054233 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55922  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: glypican
Gene Tree: Gpc6

Human homologs

Human Homolog		GPC6, glypican 6
NCBI Gene ID		10082
neXtProt AC		NX_Q9Y625
Human Synonyms		OMIMD1
Human Chr (Location)		13q32; chr13:93879078-95060274 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GPC6

Alleles and phenotypes

All alleles(7) : Targeted(6) Gene trapped(1)

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	cell migration
Component	anchored to membrane, extracellular region, ...
Function	heparan sulfate proteoglycan binding

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (3)    Tissues (3)    Images (2)
Theiler Stages: 16, 17

Assay Type	Results
RNA in situ	2
RT-PCR	1

cDNA source data(49)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(50) cDNA(49) Primer pair(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000018004 (Evidence)
Ensembl Gene Model	ENSMUSG00000058571 (Evidence)
Entrez Gene	23888 (Evidence)
UniGene	440025
DFCI	TC1584382, TC1587681, TC1624200, TC1636954, TC1647488, TC1696934
DoTS	DT.101269128, DT.101712151, DT.40153178, DT.97409368
NIA Mouse Gene Index	U015959
Consensus CDS Project	CCDS27330.1, CCDS37008.1
International Mouse Knockout Project Status	Gpc6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018004	VEGA Gene Model | MGI Sequence Detail	1054233	C57BL/6J
transcript	OTTMUST00000083121	VEGA | MGI Sequence Detail	2423	Not Applicable
polypeptide	OTTMUSP00000044609	VEGA | MGI Sequence Detail	565	Not Applicable

All sequences(51) RefSeq(4) UniProt(5)

Polymorphisms

SNPs(6527 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001863	Glypican
InterPro	IPR019803	Glypican, conserved site
Protein Ontology	PR:000008168	glypican-6

References

(Earliest) J:57579 Veugelers M, et al., Glypican-6, a new member of the glypican family of cell surface heparan sulfate proteoglycans. J Biol Chem. 1999 Sep 17;274(38):26968-77
(Latest) J:175981 Kim MS, et al., Structure of the protein core of the glypican Dally-like and localization of a region important for hedgehog signaling. Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13112-7
All references(40)

Other accession IDs

MGI:1924985, MGI:2145665