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Gpc6
Gene Detail
Symbol

Name
ID
Gpc6
glypican 6
MGI:1346322
Synonyms
6720429C22Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 14
60.34 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:116925297-117979529 bp, + strand
From VEGA annotation of GRCm38

  1054233 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55922  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GPC6
Protein SuperFamily: glypican
Gene Tree: Gpc6

Human
homologs
GPC6, glypican 6
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 10082
neXtProt AC: NX_Q9Y625

Human Synonyms: OMIMD1

Human Chr (Location): 13q32; chr13:93226825-94408020 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GPC6

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Gpc6 interacts with 436 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process cell migration
Component anchored component of membrane, extracellular region, ...
Function heparan sulfate proteoglycan binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (3)    Tissues (3)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
RT-PCR 1
cDNA source data(46)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(47) cDNA(46) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000018004 (Evidence)
Ensembl Gene Model ENSMUSG00000058571 (Evidence)
Entrez Gene 23888 (Evidence)
UniGene 440025
DFCI TC1584382, TC1587681, TC1696934, TC1647488, TC1624200, TC1636954
DoTS DT.97409368, DT.40153178, DT.101712151, DT.101269128
NIA Mouse Gene Index U015959
Consensus CDS Project CCDS27330.1, CCDS37008.1
International Mouse Phenotyping Consortium Status Gpc6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018004 VEGA Gene Model | MGI Sequence Detail 1054233 C57BL/6J ±  kb
transcript OTTMUST00000083121 VEGA | MGI Sequence Detail 2423 Not Applicable 
polypeptide OTTMUSP00000044609 VEGA | MGI Sequence Detail 565 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(8371 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001863 Glypican
InterPro IPR019803 Glypican, conserved site
Protein Ontology PR:000008168 glypican-6
References
(Earliest) J:57579 Veugelers M, et al., Glypican-6, a new member of the glypican family of cell surface heparan sulfate proteoglycans. J Biol Chem. 1999 Sep 17;274(38):26968-77
(Latest) J:219796 Ko JS, et al., PTPsigma functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1874-9
All references(42)
Other
accession IDs
MGI:1924985, MGI:2145665

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory