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Hax1
Gene Detail
 Symbol
Name
ID
Hax1
HCLS1 associated X-1
MGI:1346319
Synonyms HAX-1, HS1-associated protein X-1, Hs1bp1, mHAX-1s, Silg111
Feature Type protein coding gene
Genetic Map
Chromosome 3
39.19 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:89995457-89998686 bp, - strand
From NCBI annotation of GRCm38

  3230 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4463  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: HS1-associating protein X-1
Gene Tree: Hax1

Human
homologs
Human Homolog HAX1, HCLS1 associated protein X-1
NCBI Gene ID 10456
neXtProt AC  NX_O00165
Human Synonyms  HCLSBP1, HS1BP1, SCN3
Human Chr (Location)  1q21.3; chr1:154272563-154275875 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human HAX1
Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(17) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for deletion of this gene fail to survive beyond 14 weeks of age. Apoptosis of neurons in the striatum and cerebellum occurs as does loss of lymphocytes and neutrophiles.
 
Interactions
Hax1 interacts with 31 markers (Mir19b-1, Mir19b-2, Mir30b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process cell surface receptor signaling pathway, cellular response to cytokine stimulus, ...
Component actin cytoskeleton, apical plasma membrane, ...
Function interleukin-1 binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (3)    Tissues (3)    Images (2)
Theiler Stages: 21
Assay TypeResults
RNA in situ 3
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(10) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000027944 (Evidence)
Entrez Gene23897 (Evidence)
DFCITC1579179, TC1613095
DoTSDT.101373546, DT.101403964, DT.535698, DT.94271853, DT.97357644
NIA Mouse Gene IndexU024290, U040595
Consensus CDS ProjectCCDS17519.1
International Mouse Knockout Project StatusHax1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 23897 NCBI Gene Model | MGI Sequence Detail 3230 C57BL/6J ±  kb
transcript NM_011826 RefSeq | MGI Sequence Detail 1175 C57BL/6 
polypeptide O35387 UniProt | EBI | MGI Sequence Detail 280 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(12) UniProt(4)
Polymorphisms SNPs within 2kb(15 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017248 HS1-associating, X-1
Protein Ontology PR:000008455 HCLS1-associated protein X-1
Graphical View of Protein Domain Structure
References (Earliest) J:22945 Mixter PF, et al., Decreased CD4-CD8- TCR-alpha beta + cells in lpr/lpr mice lacking beta 2-microglobulin. J Immunol. 1995 Mar 1;154(5):2063-74
(Latest) J:174159 Peckl-Schmid D, et al., HAX1 deficiency: impact on lymphopoiesis and B-cell development. Eur J Immunol. 2010 Nov;40(11):3161-72
All references(45)
Other
accession IDs
MGD-MRK-33699, MGI:106017

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory