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Hax1
Gene Detail
Symbol

Name
ID
Hax1
HCLS1 associated X-1
MGI:1346319
Synonyms
HAX-1, HS1-associated protein X-1, Hs1bp1, mHAX-1s, Silg111
Feature Type
protein coding gene
Genetic Map
Chromosome 3
39.19 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:89995446-89998780 bp, - strand
From VEGA annotation of GRCm38

  3335 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4463  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HAX1
Protein SuperFamily: HS1-associating protein X-1
Gene Tree: Hax1

Human
homologs
HAX1, HCLS1 associated protein X-1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10456
neXtProt AC: NX_O00165

Human Synonyms: HCLSBP1, HS1BP1, SCN3

Human Chr (Location): 1q21.3; chr1:154272563-154275875 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human HAX1

Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(17) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for deletion of this gene fail to survive beyond 14 weeks of age. Apoptosis of neurons in the striatum and cerebellum occurs as does loss of lymphocytes and neutrophiles.
 
Interactions
Hax1 interacts with 31 markers (Mir19b-1, Mir19b-2, Mir30b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process cell surface receptor signaling pathway, cellular response to cytokine stimulus, ...
Component actin cytoskeleton, apical plasma membrane, ...
Function interleukin-1 binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (3)    Tissues (3)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 3
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN hax1    NEW 
Molecular
reagents
All nucleic(12) cDNA(11) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000052886 (Evidence)
Ensembl Gene Model ENSMUSG00000027944 (Evidence)
Entrez Gene 23897 (Evidence)
DFCI TC1579179, TC1613095
DoTS DT.101373546, DT.101403964, DT.535698, DT.94271853, DT.97357644
NIA Mouse Gene Index U024290, U040595
Consensus CDS Project CCDS17519.1, CCDS79956.1, CCDS79957.1
International Mouse Phenotyping Consortium Status Hax1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052886 VEGA Gene Model | MGI Sequence Detail 3335 C57BL/6J ±  kb
transcript OTTMUST00000132343 VEGA | MGI Sequence Detail 1139 Not Applicable 
polypeptide OTTMUSP00000070564 VEGA | MGI Sequence Detail 280 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(8) UniProt(11)
Polymorphisms
SNPs within 2kb(15 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017248 HS1-associating protein X-1
Protein Ontology PR:000008455 HCLS1-associated protein X-1
References
(Earliest) J:22945 Mixter PF, et al., Decreased CD4-CD8- TCR-alpha beta + cells in lpr/lpr mice lacking beta 2-microglobulin. J Immunol. 1995 Mar 1;154(5):2063-74
(Latest) J:213487 Trebinska A, et al., Exploring the anti-apoptotic role of HAX-1 versus BCL-XL in cytokine-dependent bone marrow-derived cells from mice. FEBS Lett. 2014 Aug 25;588(17):2921-7
All references(47)
Other
accession IDs
MGD-MRK-33699, MGI:106017

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory