Hax1
Gene Detail

Symbol Name ID

Hax1 HCLS1 associated X-1 MGI:1346319

Synonyms

HAX-1, HS1-associated protein X-1, Hs1bp1, mHAX-1s, Silg111

Feature Type

protein coding gene

Genetic Map

Chromosome 3

39.19 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr3:89995457-89998686 bp, - strand From NCBI annotation of GRCm38   3230 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4463  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: HS1-associating protein X-1
Gene Tree: Hax1

Human homologs

Human Homolog		HAX1, HCLS1 associated protein X-1
NCBI Gene ID		10456
neXtProt AC		NX_O00165
Human Synonyms		HCLSBP1, HS1BP1, SCN3
Human Chr (Location)		1q21.3; chr1:154245039-154248351 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human HAX1

Alleles and phenotypes

All alleles(21) : Targeted(4) Gene trapped(17)
 

Mice homozygous for deletion of this gene fail to survive beyond 14 weeks of age. Apoptosis of neurons in the striatum and cerebellum occurs as does loss of lymphocytes and neutrophiles.

 

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	cell surface receptor signaling pathway, cellular response to cytokine stimulus, ...
Component	actin cytoskeleton, cytoplasm, ...
Function	interleukin-1 binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (3)    Tissues (3)    Images (2)
Theiler Stages: 21

Assay Type	Results
RNA in situ	3

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) cDNA(10) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000027944 (Evidence)
Entrez Gene	23897 (Evidence)
DFCI	TC1579179, TC1613095
DoTS	DT.101373546, DT.101403964, DT.535698, DT.94271853
NIA Mouse Gene Index	U024290, U040595
Consensus CDS Project	CCDS17519.1
International Mouse Knockout Project Status	Hax1

Sequences

Length	Strain/Species
genomic	23897	NCBI Gene Model | MGI Sequence Detail	3230	C57BL/6J
transcript	NM_011826	RefSeq | MGI Sequence Detail	1117	C57BL/6
polypeptide	O35387	UniProt | EBI | MGI Sequence Detail	280	Not Applicable

All sequences(31) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(11 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017248	HS1-associating, X-1
Protein Ontology	PR:000008455	HCLS1-associated protein X-1

Graphical View of Protein Domain Structure

References

(Earliest) J:22945 Mixter PF, et al., Decreased CD4-CD8- TCR-alpha beta + cells in lpr/lpr mice lacking beta 2-microglobulin. J Immunol. 1995 Mar 1;154(5):2063-74
(Latest) J:174159 Peckl-Schmid D, et al., HAX1 deficiency: impact on lymphopoiesis and B-cell development. Eur J Immunol. 2010 Nov;40(11):3161-72
All references(44)

Other accession IDs

MGD-MRK-33699, MGI:106017