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Hax1
Gene Detail
Symbol

Name
ID
Hax1
HCLS1 associated X-1
MGI:1346319
Synonyms
HAX-1, HS1-associated protein X-1, Hs1bp1, mHAX-1s, Silg111
Feature Type
protein coding gene
Genetic Map
Chromosome 3
39.19 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:89995457-89998686 bp, - strand
From Ensembl annotation of GRCm38

  3230 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4463  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: HS1-associating protein X-1
Gene Tree: Hax1

Human
homologs
Human Homolog HAX1, HCLS1 associated protein X-1
NCBI Gene ID 10456
neXtProt AC  NX_O00165
Human Synonyms  HCLSBP1, HS1BP1, SCN3
Human Chr (Location)  1q21.3; chr1:154272563-154275875 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human HAX1
Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(17) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for deletion of this gene fail to survive beyond 14 weeks of age. Apoptosis of neurons in the striatum and cerebellum occurs as does loss of lymphocytes and neutrophiles.
 
Interactions
Hax1 interacts with 31 markers (Mir19b-1, Mir19b-2, Mir30b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process cell surface receptor signaling pathway, cellular response to cytokine stimulus, ...
Component actin cytoskeleton, apical plasma membrane, ...
Function interleukin-1 binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (3)    Tissues (3)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 3
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(10) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000027944 (Evidence)
Entrez Gene23897 (Evidence)
DFCITC1613095, TC1579179
DoTSDT.101403964, DT.101373546, DT.535698, DT.97357644, DT.94271853
NIA Mouse Gene IndexU040595, U024290
Consensus CDS ProjectCCDS17519.1
International Mouse Knockout Project StatusHax1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027944 Ensembl Gene Model | MGI Sequence Detail 3230 C57BL/6J ±  kb
transcript ENSMUST00000079724 Ensembl | MGI Sequence Detail 1117 Not Applicable 
polypeptide ENSMUSP00000078661 Ensembl | MGI Sequence Detail 280 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(12) UniProt(7)
Polymorphisms
SNPs within 2kb(15 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017248 HS1-associating, X-1
Protein Ontology PR:000008455 HCLS1-associated protein X-1
References
(Earliest) J:22945 Mixter PF, et al., Decreased CD4-CD8- TCR-alpha beta + cells in lpr/lpr mice lacking beta 2-microglobulin. J Immunol. 1995 Mar 1;154(5):2063-74
(Latest) J:213487 Trebinska A, et al., Exploring the anti-apoptotic role of HAX-1 versus BCL-XL in cytokine-dependent bone marrow-derived cells from mice. FEBS Lett. 2014 Aug 25;588(17):2921-7
All references(47)
Other
accession IDs
MGD-MRK-33699, MGI:106017

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory