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Klf6 Gene Detail
Summary
  • Symbol
    Klf6
  • Name
    Kruppel-like factor 6
  • Synonyms
    BCD1, Copeb, CPBP, FM2, FM6, Ierepo1, Ierepo3, Zf9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346318
    NCBI Gene: 23849
  • Gene Overview
    MyGene.info: KLF6
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:5861489-5870393 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 2.94 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    56 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346318
protein coding gene Chr13:5861482-5870394 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020212
protein coding gene Chr13:2402908-2411722 (+)
A/J MGP_AJ_G0020168
protein coding gene Chr13:2465709-2474655 (+)
AKR/J MGP_AKRJ_G0020143
protein coding gene Chr13:2509938-2518835 (+)
BALB/cJ MGP_BALBcJ_G0020151
protein coding gene Chr13:2453109-2462035 (+)
C3H/HeJ MGP_C3HHeJ_G0019955
protein coding gene Chr13:2616255-2625704 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020598
protein coding gene Chr13:2560579-2569477 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018208
protein coding gene Chr13:2402668-2411608 (+)
CAST/EiJ MGP_CASTEiJ_G0019495
protein coding gene Chr13:2378732-2393160 (+)
CBA/J MGP_CBAJ_G0019922
protein coding gene Chr13:2606364-2617401 (+)
DBA/2J MGP_DBA2J_G0020039
protein coding gene Chr13:2362810-2374123 (+)
FVB/NJ MGP_FVBNJ_G0020024
protein coding gene Chr13:2261848-2270660 (+)
LP/J MGP_LPJ_G0020113
protein coding gene Chr13:2498635-2507533 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020060
protein coding gene Chr13:2847927-2857308 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020626
protein coding gene Chr13:2454056-2462947 (+)
PWK/PhJ MGP_PWKPhJ_G0019256
protein coding gene Chr13:2414454-2443265 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019063
protein coding gene Chr13:2511252-2523756 (+)
WSB/EiJ MGP_WSBEiJ_G0019553
protein coding gene Chr13:2396486-2408289 (+)



Homology
more
  • Human Ortholog
    KLF6, Kruppel like factor 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KLF6, Kruppel like factor 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BCD1, CBA1, COPEB, CPBP, GBF, PAC1, ST12, ZF9
  • Links
    NCBI Gene ID: 1316
    neXtProt AC: NX_Q99612
    UniProt: Q99612

  • Chr Location
    10p15.2; chr10:3775996-3785281 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 996
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: KLF6
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human KLF6 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    3 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality during organogenesis, small size, pallor, decreased cellular proliferation and delayed liver development. Mice heterozygous for a null allele exhibit delays in embryonic hematopoeisis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23849 NCBI Gene Model | MGI Sequence Detail 8905 C57BL/6J ±  kb
    transcript NM_011803 RefSeq | MGI Sequence Detail 4217 C57BL/6  
    polypeptide O08584 UniProt | EBI | MGI Sequence Detail 283 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR036236 Zinc finger C2H2 superfamily
      IPR013087 Zinc finger C2H2-type
    Molecular
    Reagents
    less
    • All nucleic 145
      cDNA 143
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1932268, MGI:1932273, MGI:2145240, MGI:2145533, MGI:2145544
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 15
      Gene Ontology 10
      Phenotypes 18
    • Earliest
      J:56736 Philipsen S, et al., A tale of three fingers: the family of mammalian Sp/XKLF transcription factors. Nucleic Acids Res. 1999 Aug 1;27(15):2991-3000
    • Latest
      J:265905 Horne SJ, et al., Podocyte-Specific Loss of Kruppel-Like Factor 6 Increases Mitochondrial Injury in Diabetic Kidney Disease. Diabetes. 2018 Nov;67(11):2420-2433

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory