Klf6
Gene Detail

Symbol

Name
ID

Klf6
Kruppel-like factor 6
MGI:1346318

Synonyms

BCD1, Copeb, CPBP, FM2, FM6, Ierepo1, Ierepo3, Zf9

Feature Type

protein coding gene

Genetic Map

Chromosome 13
2.94 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr13:5861489-5870393 bp, + strand From NCBI annotation of GRCm38   8905 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:996  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Klf6

Human
homologs

Human Homolog		KLF6, Kruppel-like factor 6
NCBI Gene ID		1316
neXtProt AC		NX_Q99612
Human Synonyms		BCD1, CBA1, COPEB, CPBP, GBF, PAC1, ST12, ZF9
Human Chr (Location)		10p15; chr10:3775996-3785281 (-)  GRCh38
Disease Associations		(2) Diseases Associated with Human KLF6

Mutations,
alleles, and
phenotypes

All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a null allele exhibit embryonic lethality during organogenesis, small size, pallor, decreased cellular proliferation and delayed liver development. Mice heterozygous for a null allele exhibit delays in embryonic hematopoeisis.

 

Interactions

Klf6 interacts with 417 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (13 annotations)

Process	cytokine-mediated signaling pathway, positive regulation of transcription from RNA polymerase II promoter, ...
Component	cytoplasm, nucleus
Function	DNA binding, double-stranded DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)

Data Summary: Results (121)    Tissues (88)    Images (42)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	112
Northern blot	1
RT-PCR	8

cDNA source data(141)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(144) cDNA(142) Primer pair(2)
Microarray probesets(6)

Other database
links

Ensembl Gene Model	ENSMUSG00000000078 (Evidence)
Entrez Gene	23849 (Evidence)
UniGene	275036
DFCI	TC1572894, TC1619481, TC1602643
DoTS	DT.101387490, DT.97409377, DT.94291663, DT.94140851, DT.55237674
NIA Mouse Gene Index	U014517
Consensus CDS Project	CCDS26229.1
International Mouse Knockout Project Status	Klf6

Sequences

Length	Strain/Species
genomic	23849	NCBI Gene Model | MGI Sequence Detail	8905	C57BL/6J
transcript	NM_011803	RefSeq | MGI Sequence Detail	4217	C57BL/6
polypeptide	O08584	UniProt | EBI | MGI Sequence Detail	283	Not Applicable

All sequences(43) RefSeq(2) UniProt(9)

Polymorphisms

SNPs within 2kb(56 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000009366	krueppel-like factor 6

Graphical View of Protein Domain Structure

References

(Earliest) J:56736 Philipsen S, et al., A tale of three fingers: the family of mammalian Sp/XKLF transcription factors. Nucleic Acids Res. 1999 Aug 1;27(15):2991-3000
(Latest) J:208419 Basta JM, et al., Sall1 balances self-renewal and differentiation of renal progenitor cells. Development. 2014 Mar;141(5):1047-58
All references(53)

Other
accession IDs

MGI:1932268, MGI:1932273, MGI:2145240, MGI:2145533, MGI:2145544