Klf6 MGI Mouse Gene Detail - MGI:1346318

Symbol

Klf6
Name

Kruppel-like factor 6
Synonyms

BCD1, Copeb, CPBP, FM2, FM6, Ierepo1, Ierepo3, Zf9

Feature Type

protein coding gene
IDs

MGI:1346318
NCBI Gene: 23849
Gene Overview

MyGene.info: KLF6
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr13:5861489-5870393 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 2.94 cM, cytoband A1
Mapping Data

2 experiments

SNPs within 2kb

56 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346318	protein coding gene	Chr13:5861482-5870394 (.)
129S1/SvImJ	MGP_129S1SvImJ_G0020212	protein coding gene	Chr13:2402908-2411722 (+)
A/J	MGP_AJ_G0020168	protein coding gene	Chr13:2465709-2474655 (+)
AKR/J	MGP_AKRJ_G0020143	protein coding gene	Chr13:2509938-2518835 (+)
BALB/cJ	MGP_BALBcJ_G0020151	protein coding gene	Chr13:2453109-2462035 (+)
C3H/HeJ	MGP_C3HHeJ_G0019955	protein coding gene	Chr13:2616255-2625704 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020598	protein coding gene	Chr13:2560579-2569477 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018208	protein coding gene	Chr13:2402668-2411608 (+)
CAST/EiJ	MGP_CASTEiJ_G0019495	protein coding gene	Chr13:2378732-2393160 (+)
CBA/J	MGP_CBAJ_G0019922	protein coding gene	Chr13:2606364-2617401 (+)
DBA/2J	MGP_DBA2J_G0020039	protein coding gene	Chr13:2362810-2374123 (+)
FVB/NJ	MGP_FVBNJ_G0020024	protein coding gene	Chr13:2261848-2270660 (+)
LP/J	MGP_LPJ_G0020113	protein coding gene	Chr13:2498635-2507533 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020060	protein coding gene	Chr13:2847927-2857308 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020626	protein coding gene	Chr13:2454056-2462947 (+)
PWK/PhJ	MGP_PWKPhJ_G0019256	protein coding gene	Chr13:2414454-2443265 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019063	protein coding gene	Chr13:2511252-2523756 (+)
WSB/EiJ	MGP_WSBEiJ_G0019553	protein coding gene	Chr13:2396486-2408289 (+)

Human Ortholog

KLF6, Kruppel like factor 6

Vertebrate Orthologs

10

Human Ortholog

KLF6, Kruppel like factor 6
Orthology source: HomoloGene, HGNC
Synonyms

BCD1, CBA1, COPEB, CPBP, GBF, PAC1, ST12, ZF9
Links

HGNC:2235

NCBI Gene ID: 1316

neXtProt AC: NX_Q99612

UniProt: Q99612
Chr Location

10p15.2; chr10:3775996-3785281 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 996
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: KLF6
Gene Tree

Klf6

Diseases

2 with human KLF6 associations

				Human Disease	Mouse Models
				prostate cancer IDs prostate cancer DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358
				stomach cancer IDs stomach cancer DOID:10534 DOID:10539 DOID:10542 DOID:10543 DOID:4713 ICD10CM:C16 ICD10CM:C16.2 ICD10CM:C16.5 ICD10CM:C16.6 ICD10CM:C16.9 ICD9CM:151 ICD9CM:151.4 ICD9CM:151.5 ICD9CM:151.6 ICD9CM:151.9 MESH:D013274 NCI:C3387 NCI:C9331 OMIM:137215 OMIM:613659 UMLS_CUI:C0024623 UMLS_CUI:C0038356 UMLS_CUI:C0153421 UMLS_CUI:C0153422 UMLS_CUI:C0153423

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

13 phenotypes from 2 alleles in 3 genetic backgrounds
5 phenotypes from multigenic genotypes
3 images
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Gene trapped

2
Targeted

5
Transgenic

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

4 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit embryonic lethality during organogenesis, small size, pallor, decreased cellular proliferation and delayed liver development. Mice heterozygous for a null allele exhibit delays in embryonic hematopoeisis.

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All GO Annotations

31
GO References

10

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

124
Tissues

91
cDNA Data

142
Literature Summary

15

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA KLF6

Xenbase klf6

ZFIN klf6a

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Klf6 interacts with 416 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

52
RefSeq

2
UniProt

6
CCDS

CCDS26229.1
UniGene

275036

Ensembl

ENSMUSG00000000078 (Evidence)
NCBI Gene

23849

			Length	Strain/Species	Flank
genomic	23849	NCBI Gene Model \| MGI Sequence Detail	8905	C57BL/6J	± kb
transcript	NM_011803	RefSeq \| MGI Sequence Detail	4217	C57BL/6
polypeptide	O08584	UniProt \| EBI \| MGI Sequence Detail	283	Not Applicable

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UniProt

6 Sequences
InterPro Domains

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 145

cDNA 143

Primer pair 2

Microarray probesets 6

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MGI:1932268, MGI:1932273, MGI:2145240, MGI:2145533, MGI:2145544

Summaries

All 67

Developmental Gene Expression 15

Gene Ontology 10

Phenotypes 18
Earliest

J:56736 Philipsen S, et al., A tale of three fingers: the family of mammalian Sp/XKLF transcription factors. Nucleic Acids Res. 1999 Aug 1;27(15):2991-3000
Latest

J:265905 Horne SJ, et al., Podocyte-Specific Loss of Kruppel-Like Factor 6 Increases Mitochondrial Injury in Diabetic Kidney Disease. Diabetes. 2018 Nov;67(11):2420-2433

TSS for Klf6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr118237	Chr13:5861494-5861501 (+)	9 bp
Tssr118238	Chr13:5861503-5861526 (+)	26 bp
Tssr118239	Chr13:5861530-5861550 (+)	51 bp
Tssr118240	Chr13:5861553-5861564 (+)	70 bp
Tssr118241	Chr13:5861626-5861637 (+)	143 bp
Tssr118242	Chr13:5861662-5861673 (+)	179 bp
Tssr118243	Chr13:5861862-5861875 (+)	380 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/08/2019 MGI 6.13