Klf6
Gene Detail

Symbol Name ID

Klf6 Kruppel-like factor 6 MGI:1346318

Synonyms

BCD1, Copeb, CPBP, FM2, FM6, Ierepo1, Ierepo3, Zf9

Feature Type

protein coding gene

Genetic Map

Chromosome 13

2.94 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr13:5861489-5870393 bp, + strand From NCBI annotation of GRCm38   8905 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:996  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Klf6

Human homologs

Human Homolog		KLF6, Kruppel-like factor 6
NCBI Gene ID		1316
neXtProt AC		NX_Q99612
Human Synonyms		BCD1, CBA1, COPEB, CPBP, GBF, PAC1, ST12, ZF9
Human Chr (Location)		10p15; chr10:3775996-3785281 (-)  GRCh38
Disease Associations		(2) Diseases Associated with Human KLF6

Alleles and phenotypes

All alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a null allele exhibit embryonic lethality during organogenesis, small size, pallor, decreased cellular proliferation and delayed liver development. Mice heterozygous for a null allele exhibit delays in embryonic hematopoeisis.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	cytokine-mediated signaling pathway, positive regulation of transcription from RNA polymerase II promoter, ...
Component	cytoplasm, nucleus
Function	DNA binding, double-stranded DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)

Data Summary: Results (128)    Tissues (93)    Images (42)
Theiler Stages: 2, 3, 4, 5, 15, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	112
Northern blot	1
RT-PCR	15

cDNA source data(141)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(144) cDNA(142) Primer pair(2)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000000078 (Evidence)
Entrez Gene	23849 (Evidence)
UniGene	275036
DFCI	TC1572894, TC1602643, TC1619481
DoTS	DT.101387490, DT.55237674, DT.94140851, DT.94291663, DT.97409377
NIA Mouse Gene Index	U014517
Consensus CDS Project	CCDS26229.1
International Mouse Knockout Project Status	Klf6

Sequences

Length	Strain/Species
genomic	23849	NCBI Gene Model | MGI Sequence Detail	8905	C57BL/6J
transcript	NM_011803	RefSeq | MGI Sequence Detail	4217	C57BL/6
polypeptide	O08584	UniProt | EBI | MGI Sequence Detail	283	Not Applicable

All sequences(39) RefSeq(2) UniProt(5)

Polymorphisms

SNPs within 2kb(56 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000009366	krueppel-like factor 6

Graphical View of Protein Domain Structure

References

(Earliest) J:56736 Philipsen S, et al., A tale of three fingers: the family of mammalian Sp/XKLF transcription factors. Nucleic Acids Res. 1999 Aug 1;27(15):2991-3000
(Latest) J:177911 Lu PP, et al., Serum response factor is required for cortical axon growth but is dispensable for neurogenesis and neocortical lamination. J Neurosci. 2011 Nov 16;31(46):16651-64
All references(50)

Other accession IDs

MGI:1932268, MGI:1932273, MGI:2145240, MGI:2145533, MGI:2145544