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Klf6
Gene Detail
Symbol

Name
ID
Klf6
Kruppel-like factor 6
MGI:1346318
Synonyms
BCD1, Copeb, CPBP, FM2, FM6, Ierepo1, Ierepo3, Zf9
Feature Type
protein coding gene
Genetic Map
Chromosome 13
2.94 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:5861489-5870393 bp, + strand
From NCBI annotation of GRCm38

  8905 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:996  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: KLF6
Gene Tree: Klf6

Human
homologs
KLF6, Kruppel-like factor 6
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1316
neXtProt AC: NX_Q99612

Human Synonyms: BCD1, CBA1, COPEB, CPBP, GBF, PAC1, ST12, ZF9

Human Chr (Location): 10p15; chr10:3775996-3785281 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human KLF6

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit embryonic lethality during organogenesis, small size, pallor, decreased cellular proliferation and delayed liver development. Mice heterozygous for a null allele exhibit delays in embryonic hematopoeisis.
 
Interactions
Klf6 interacts with 416 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (13 records)
Data Summary: Results (121)    Tissues (88)    Images (42)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 112
Northern blot 1
RT-PCR 8
cDNA source data(141)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA KLF6 ; Xenbase klf6 ; ZFIN klf6a    NEW 
Molecular
reagents
All nucleic(144) cDNA(142) Primer pair(2)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000000078 (Evidence)
Entrez Gene 23849 (Evidence)
UniGene 275036
DFCI TC1572894, TC1602643, TC1619481
DoTS DT.101387490, DT.55237674, DT.94140851, DT.94291663, DT.97409377
NIA Mouse Gene Index U014517
Consensus CDS Project CCDS26229.1
International Mouse Phenotyping Consortium Status Klf6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 23849 NCBI Gene Model | MGI Sequence Detail 8905 C57BL/6J ±  kb
transcript NM_011803 RefSeq | MGI Sequence Detail 4217 C57BL/6 
polypeptide O08584 UniProt | EBI | MGI Sequence Detail 283 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(56 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000009366 krueppel-like factor 6
Graphical View of Protein Domain Structure
References
(Earliest) J:56736 Philipsen S, et al., A tale of three fingers: the family of mammalian Sp/XKLF transcription factors. Nucleic Acids Res. 1999 Aug 1;27(15):2991-3000
(Latest) J:220539 Mallipattu SK, et al., Kruppel-like factor 6 regulates mitochondrial function in the kidney. J Clin Invest. 2015 Mar 2;125(3):1347-61
All references(52)
Other
accession IDs
MGI:1932268, MGI:1932273, MGI:2145240, MGI:2145533, MGI:2145544

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory