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Klf6
Gene Detail
 Symbol
Name
ID
Klf6
Kruppel-like factor 6
MGI:1346318
Synonyms BCD1, Copeb, CPBP, FM2, FM6, Ierepo1, Ierepo3, Zf9
Feature Type protein coding gene
Genetic Map
Chromosome 13
2.94 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:5861489-5870393 bp, + strand
From NCBI annotation of GRCm38

  8905 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:996  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Klf6

Human
homologs
Human Homolog KLF6, Kruppel-like factor 6
NCBI Gene ID 1316
neXtProt AC  NX_Q99612
Human Synonyms  BCD1, CBA1, COPEB, CPBP, GBF, PAC1, ST12, ZF9
Human Chr (Location)  10p15; chr10:3775996-3785281 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human KLF6
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit embryonic lethality during organogenesis, small size, pallor, decreased cellular proliferation and delayed liver development. Mice heterozygous for a null allele exhibit delays in embryonic hematopoeisis.
 
Interactions
Klf6 interacts with 417 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cytokine-mediated signaling pathway, positive regulation of transcription from RNA polymerase II promoter, ...
Component cytoplasm, nucleus
Function DNA binding, double-stranded DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (121)    Tissues (88)    Images (42)
Theiler Stages: 2, 3, 4, 5, 15, 17, 18, 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 112
Northern blot 1
RT-PCR 8
cDNA source data(141)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(144) cDNA(142) Primer pair(2)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000000078 (Evidence)
Entrez Gene23849 (Evidence)
UniGene275036
DFCITC1572894, TC1602643, TC1619481
DoTSDT.101387490, DT.55237674, DT.94140851, DT.94291663, DT.97409377
NIA Mouse Gene IndexU014517
Consensus CDS ProjectCCDS26229.1
International Mouse Knockout Project StatusKlf6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 23849 NCBI Gene Model | MGI Sequence Detail 8905 C57BL/6J ±  kb
transcript NM_011803 RefSeq | MGI Sequence Detail 4217 C57BL/6 
polypeptide O08584 UniProt | EBI | MGI Sequence Detail 283 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(2) UniProt(5)
Polymorphisms SNPs within 2kb(56 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000009366 krueppel-like factor 6
Graphical View of Protein Domain Structure
References (Earliest) J:56736 Philipsen S, et al., A tale of three fingers: the family of mammalian Sp/XKLF transcription factors. Nucleic Acids Res. 1999 Aug 1;27(15):2991-3000
(Latest) J:209112 Shimizu H, et al., The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
All references(51)
Other
accession IDs
MGI:1932268, MGI:1932273, MGI:2145240, MGI:2145533, MGI:2145544

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory