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Klf6 Gene Detail
Summary
  • Symbol
    Klf6
  • Name
    Kruppel-like factor 6
  • Synonyms
    BCD1, Copeb, CPBP, FM2, FM6, Ierepo1, Ierepo3, Zf9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346318
    NCBI Gene: 23849
  • Gene Overview
    MyGene.info: KLF6
Location & Maps
more
  • Genetic Map
    Chromosome 13, 2.94 cM, cytoband A1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    KLF6, Kruppel like factor 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KLF6, Kruppel like factor 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BCD1, CBA1, COPEB, CPBP, GBF, PAC1, ST12, ZF9
  • Links
    NCBI Gene ID: 1316
    neXtProt AC: NX_Q99612

  • Chr Location
    10p15; chr10:3775996-3785281 (-)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 996
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: KLF6
  • Gene Tree
    Klf6
Human Diseases
more
  • Diseases
    2 with human KLF6 associations

Human Disease Mouse Models
       Gastric Cancer   OMIM: 613659
Prostate Cancer   OMIM: 176807
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Gene trapped
    2
  • Targeted
    5
  • Transgenic
    1
  • Incidental Mutations
    Mutagenetix , APF
Mice homozygous for a null allele exhibit embryonic lethality during organogenesis, small size, pallor, decreased cellular proliferation and delayed liver development. Mice heterozygous for a null allele exhibit delays in embryonic hematopoeisis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    121
  • Tissues
    88
  • cDNA Data
    141
  • Literature Summary
    14
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 23849 NCBI Gene Model | MGI Sequence Detail 8905 C57BL/6J ±  kb
transcript NM_011803 RefSeq | MGI Sequence Detail 4217 C57BL/6  
polypeptide O08584 UniProt | EBI | MGI Sequence Detail 283 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    56 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000009366 krueppel-like factor 6
  • InterPro Domains
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
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  • All nucleic 144
    cDNA 142
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
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MGI:1932268, MGI:1932273, MGI:2145240, MGI:2145533, MGI:2145544
References
more
  • Summaries
    All 52
    Developmental Gene Expression 14
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:56736 Philipsen S, et al., A tale of three fingers: the family of mammalian Sp/XKLF transcription factors. Nucleic Acids Res. 1999 Aug 1;27(15):2991-3000
  • Latest
    J:232556 Bao J, et al., UPF2-Dependent Nonsense-Mediated mRNA Decay Pathway Is Essential for Spermatogenesis by Selectively Eliminating Longer 3'UTR Transcripts. PLoS Genet. 2016 May;12(5):e1005863
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory