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Nr2e3
Gene Detail
Symbol

Name
ID
Nr2e3
nuclear receptor subfamily 2, group E, member 3
MGI:1346317
Synonyms
photoreceptor-specific nuclear receptor, Pnr, RNR
Feature Type
protein coding gene
Genetic Map
Chromosome 9
32.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr9:59942771-59960659 bp, - strand
From VEGA annotation of GRCm38

  17889 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:84397  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: retinoic X receptor-like nuclear receptor
Gene Tree: Nr2e3

Human
homologs
Human Homolog NR2E3, nuclear receptor subfamily 2, group E, member 3
NCBI Gene ID 10002
neXtProt AC  NX_Q9Y5X4
Human Synonyms  ESCS, PNR, rd7, RNR, RP37
Human Chr (Location)  15q23; chr15:71810548-71818259 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human NR2E3
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Spontaneous(1) Targeted(1)
 
Mice homozygous for a null mutation exhibit rossettes and a reduced number of nuclei in the retinal outer nuclear layer.
 
Human Diseases Modeled Using Mouse Nr2e3 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Nr2e3 interacts with 107 markers (Mir17, Mir18, Mir18b, ...)
Expression
Literature Summary: (25 records)
Data Summary: Results (175)    Tissues (162)    Images (36)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 156
Western blot 3
RT-PCR 15
cDNA source data(49)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(52) cDNA(50) Primer pair(2)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000023008 (Evidence)
Ensembl Gene ModelENSMUSG00000032292 (Evidence)
Entrez Gene23958 (Evidence)
UniGene103641
DFCITC1601332, TC1581983, TC1622013, TC1612808, TC1632168
DoTSDT.101302896, DT.87056518, DT.101731660, DT.97411780, DT.101349738, DT.91318774
NIA Mouse Gene IndexU030954
Consensus CDS ProjectCCDS23255.1
International Mouse Knockout Project StatusNr2e3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023008 VEGA Gene Model | MGI Sequence Detail 17889 C57BL/6J ±  kb
transcript OTTMUST00000055414 VEGA | MGI Sequence Detail 2037 Not Applicable 
polypeptide OTTMUSP00000026535 VEGA | MGI Sequence Detail 395 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(8) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(172 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR001723 Steroid hormone receptor
InterPro IPR003068 Transcription factor COUP
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000011403 photoreceptor-specific nuclear receptor
References
(Earliest) J:55816 Chang B, et al., A new mouse model of retinal dysplasia and degeneration (rd7). Invest Ophthalmol Vis Sci. 1998;39(4):S880 (Abstr.)
(Latest) J:212853 Cruz NM, et al., Modifier genes as therapeutics: the nuclear hormone receptor Rev Erb alpha (Nr1d1) rescues Nr2e3 associated retinal disease. PLoS One. 2014;9(1):e87942
All references(72)
Disease annotation references (3)
Other
accession IDs
MGI:1354383, MGI:2444464

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory