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Nr2e3 Gene Detail
Summary
  • Symbol
    Nr2e3
  • Name
    nuclear receptor subfamily 2, group E, member 3
  • Synonyms
    photoreceptor-specific nuclear receptor, Pnr, RNR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346317
    NCBI Gene: 23958
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:59850054-59867942 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 32.35 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    901 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346317
 protein coding gene Chr9:59850054-59868117 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034908
 protein coding gene Chr9:59332807-59350591 (-)
A/J MGP_AJ_G0034888
 protein coding gene Chr9:57426112-57443964 (-)
AKR/J MGP_AKRJ_G0034818
 protein coding gene Chr9:58761499-58780586 (-)
BALB/cJ MGP_BALBcJ_G0034881
 protein coding gene Chr9:57144070-57161905 (-)
C3H/HeJ MGP_C3HHeJ_G0034591
 protein coding gene Chr9:59234135-59251956 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035400
 protein coding gene Chr9:60957539-60975108 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032311
 protein coding gene Chr9:57142628-57160407 (-)
CAST/EiJ MGP_CASTEiJ_G0033912
 protein coding gene Chr9:59331190-59348611 (-)
CBA/J MGP_CBAJ_G0034562
 protein coding gene Chr9:63115956-63133797 (-)
DBA/2J MGP_DBA2J_G0034721
 protein coding gene Chr9:57231013-57248771 (-)
FVB/NJ MGP_FVBNJ_G0034663
 protein coding gene Chr9:56500413-56520139 (-)
LP/J MGP_LPJ_G0034804
 protein coding gene Chr9:59623596-59642749 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034706
 protein coding gene Chr9:64571006-64589753 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035422
 protein coding gene Chr9:58771438-58790207 (-)
PWK/PhJ MGP_PWKPhJ_G0033616
 protein coding gene Chr9:57301838-57319741 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033449
 protein coding gene Chr9:59035234-59053050 (-)
WSB/EiJ MGP_WSBEiJ_G0034025
 protein coding gene Chr9:58707590-58726421 (-)



Homology
more
  • Human Ortholog
    NR2E3, nuclear receptor subfamily 2 group E member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NR2E3, nuclear receptor subfamily 2 group E member 3
  • Synonyms
    ESCS, PNR, rd7, RNR, RP37
  • Links
    NCBI Gene ID: 10002
    UniProt: Q9Y5X4

  • Chr Location
    15q23; chr15:71792638-71818259 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Nr2e3 mouse models; 2 with human NR2E3 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 3 genetic backgrounds
    2 images
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation exhibit rossettes and a reduced number of nuclei in the retinal outer nuclear layer.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    986
  • Tissues
    205
  • cDNA Data
    50
  • Literature Summary
    45
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032292 Ensembl Gene Model | MGI Sequence Detail 17889 C57BL/6J ±  kb
    transcript ENSMUST00000034831 Ensembl | MGI Sequence Detail 2037 Not Applicable  
    polypeptide ENSMUSP00000034831 Ensembl | MGI Sequence Detail 395 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000011403 photoreceptor-specific nuclear receptor
      (term hierarchy)
    • InterPro Domains
      IPR001723 Nuclear hormone receptor
      IPR050274 Nuclear hormone receptor family NR2 subfamily
      IPR000536 Nuclear hormone receptor, ligand-binding domain
      IPR035500 Nuclear hormone receptor-like domain superfamily
      IPR013088 Zinc finger, NHR/GATA-type
      IPR001628 Zinc finger, nuclear hormone receptor-type
    Molecular
    Reagents
    less
    • All nucleic 59
      cDNA 51
      Primer pair 6
      Other 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1354383, MGI:2444464
    References
    more
    • Summaries
      All 114
      Developmental Gene Expression 45
      Diseases 2
      Gene Ontology 12
      Phenotypes 38
    • Earliest
      J:55816 Chang B, et al., A new mouse model of retinal dysplasia and degeneration (rd7). Invest Ophthalmol Vis Sci. 1998;39(4):S880 (Abstr.)
    • Latest
      J:360858 Aisa-Marin I, et al., Specific photoreceptor cell fate pathways are differentially altered in NR2E3-associated diseases. Neurobiol Dis. 2024 Mar 12;194:106463
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    03/25/2025
    MGI 6.24     		The Jackson Laboratory