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Ccl19 Gene Detail
Summary
  • Symbol
    Ccl19
  • Name
    chemokine (C-C motif) ligand 19
  • Synonyms
    CKb11, exodus-3, Scya19
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346316
    NCBI Gene: 24047
  • Gene Overview
    MyGene.info: CCL19
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr4:42754525-42756518 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 22.80 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5 from dbSNP Build 142
  • Strain Annotations
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346316
protein coding gene Chr4:42754525-42756577 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028180
protein coding gene Chr4:40065355-40066219 (-)
A/J MGP_AJ_G0028143
protein coding gene Chr4:38253675-39337877 (-)
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0028605
protein coding gene Chr4:42337789-42338663 (-)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0027962
protein coding gene Chr4:37499556-37503049 (-)
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0027054
protein coding gene Chr4:38241528-38250857 (-)
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CCL19, C-C motif chemokine ligand 19
  • Vertebrate Orthologs
    14
  • Human Ortholog
    CCL19, C-C motif chemokine ligand 19
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CKb11, ELC, MIP-3b, MIP3B, SCYA19
  • Links
    NCBI Gene ID: 6363
    neXtProt AC: NX_Q99731
    UniProt: Q99731

  • Chr Location
    9p13.3; chr9:34689570-34691277 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in reduced T cell numbers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 24047 NCBI Gene Model | MGI Sequence Detail 1994 C57BL/6J ±  kb
    transcript NM_011888 RefSeq | MGI Sequence Detail 720 Not Specified  
    polypeptide O70460 UniProt | EBI | MGI Sequence Detail 108 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 7
      cDNA 11
      Primer pair 1
      Other 1

      Microarray probesets 7
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 6
      Gene Ontology 9
      Phenotypes 6
    • Earliest
      J:57559 Ngo VN, et al., Epstein-Barr virus-induced molecule 1 ligand chemokine is expressed by dendritic cells in lymphoid tissues and strongly attracts naive T cells and activated B cells. J Exp Med. 1998 Jul 6;188(1):181-91
    • Latest
      J:251128 Jafarnejad M, et al., A Novel Computational Model Predicts Key Regulators of Chemokine Gradient Formation in Lymph Nodes and Site-Specific Roles for CCL19 and ACKR4. J Immunol. 2017 Oct 1;199(7):2291-2304

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory