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Nr1i3
Gene Detail
 Symbol
Name
ID
Nr1i3
nuclear receptor subfamily 1, group I, member 3
MGI:1346307
Synonyms CAR, CAR1, Care2, ESTM32, MB67, mCAR
Feature Type protein coding gene
Genetic Map
Chromosome 1
79.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr1:171213970-171220701 bp, + strand
From VEGA annotation of GRCm38

  6732 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3759  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: vitamin D3 receptor-like nuclear receptor
Gene Tree: Nr1i3

Human
homologs
Human Homolog NR1I3, nuclear receptor subfamily 1, group I, member 3
NCBI Gene ID 9970
neXtProt AC  NX_Q14994
Human Synonyms  CAR, CAR1, MB67
Human Chr (Location)  1q23.3; chr1:161229666-161238642 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased sensitivity to TCPOBOP.
 
Interactions
Nr1i3 interacts with 24 markers (Mir33, Mir93, Mir133b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process negative regulation of transcription, DNA-templated, positive regulation of transcription from RNA polymerase II promoter, ...
Component cytoplasm, cytoskeleton, ...
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (51)    Tissues (49)    Images (10)
Theiler Stages: 16, 17, 18, 21, 23, 28
Assay TypeResults
RNA in situ 51
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) Genomic(1) cDNA(11) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022426 (Evidence)
Ensembl Gene ModelENSMUSG00000005677 (Evidence)
Entrez Gene12355 (Evidence)
PDB1XLS, 1XNX
Consensus CDS ProjectCCDS15480.1, CCDS56654.1, CCDS56655.1
International Mouse Knockout Project StatusNr1i3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022426 VEGA Gene Model | MGI Sequence Detail 6732 C57BL/6J ±  kb
transcript OTTMUST00000053615 VEGA | MGI Sequence Detail 1414 Not Applicable 
polypeptide OTTMUSP00000025500 VEGA | MGI Sequence Detail 358 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(18) UniProt(5)
Polymorphisms PCR(1) : SNPs within 2kb(157 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR001723 Steroid hormone receptor
InterPro IPR001728 Thyroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000011398 nuclear receptor subfamily 1 group I member 3
References (Earliest) J:43027 Choi HS, et al., Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR. J Biol Chem. 1997 Sep 19;272(38):23565-71
(Latest) J:206910 Zhang YK, et al., Expression of human CAR splicing variants in BAC-transgenic mice. Toxicol Sci. 2013 Mar;132(1):142-50
All references(92)
Other
accession IDs
MGI:1313311, MGI:1334464, MGI:2138288

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory