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Nr1i3 Gene Detail
Summary
  • Symbol
    Nr1i3
  • Name
    nuclear receptor subfamily 1, group I, member 3
  • Synonyms
    CAR, CAR1, Care2, ESTM32, MB67, mCAR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346307
    NCBI Gene: 12355
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:171213932-171218845 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 79.21 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    121 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346307
protein coding gene Chr1:171213932-171220701 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016745
protein coding gene Chr1:176994769-177001504 (+)
A/J MGP_AJ_G0016725
protein coding gene Chr1:169795445-169802171 (+)
AKR/J MGP_AKRJ_G0016691
protein coding gene Chr1:174878628-174885359 (+)
BALB/cJ MGP_BALBcJ_G0016686
protein coding gene Chr1:170277929-170284664 (+)
C3H/HeJ MGP_C3HHeJ_G0016509
protein coding gene Chr1:175126020-175132755 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017147
protein coding gene Chr1:182878365-182885096 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014855
protein coding gene Chr1:161475504-161482227 (+)
CAST/EiJ MGP_CASTEiJ_G0016090
protein coding gene Chr1:174750269-174757000 (+)
CBA/J MGP_CBAJ_G0016484
protein coding gene Chr1:189390034-189396769 (+)
DBA/2J MGP_DBA2J_G0016591
protein coding gene Chr1:168634325-168641060 (+)
FVB/NJ MGP_FVBNJ_G0016587
protein coding gene Chr1:166983397-166990129 (+)
LP/J MGP_LPJ_G0016662
protein coding gene Chr1:178115974-178122709 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016614
protein coding gene Chr1:196676070-196682805 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017184
protein coding gene Chr1:174751401-174758127 (+)
PWK/PhJ MGP_PWKPhJ_G0015876
protein coding gene Chr1:167857306-167864032 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015660
protein coding gene Chr1:173536568-173543226 (+)
WSB/EiJ MGP_WSBEiJ_G0016152
protein coding gene Chr1:174869814-174876541 (+)



Homology
more
  • Human Ortholog
    NR1I3, nuclear receptor subfamily 1 group I member 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NR1I3, nuclear receptor subfamily 1 group I member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAR, CAR1, MB67
  • Links
    NCBI Gene ID: 9970
    neXtProt AC: NX_Q14994
    UniProt: Q14994

  • Chr Location
    1q23.3; chr1:161229666-161238623 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 4 alleles in 5 genetic backgrounds
    3 phenotypes from multigenic genotypes
    62 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased sensitivity to TCPOBOP.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12355 NCBI Gene Model | MGI Sequence Detail 4914 C57BL/6J ±  kb
    transcript NM_009803 RefSeq | MGI Sequence Detail 1428 C57BL/6  
    polypeptide O35627 UniProt | EBI | MGI Sequence Detail 358 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 1
      cDNA 12
      Primer pair 3
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1313311, MGI:1334464, MGI:2138288
    References
    more
    • Summaries
      All 136
      Developmental Gene Expression 8
      Gene Ontology 9
      Phenotypes 62
    • Earliest
      J:33440 Seol W, et al., An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors. Science. 1996 May 31;272(5266):1336-9
    • Latest
      J:263993 Hori T, et al., Nuclear Receptor CAR Suppresses GADD45B-p38 MAPK Signaling to Promote Phenobarbital-induced Proliferation in Mouse Liver. Mol Cancer Res. 2018 Aug;16(8):1309-1318

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory