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Nelfa Gene Detail
Summary
  • Symbol
    Nelfa
  • Name
    negative elongation factor complex member A, Whsc2
  • Synonyms
    Nelf-A, Whsc2, Whsc2h
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346098
    NCBI Gene: 24116
  • Gene Overview
    MyGene.info: NELFA
Location & Maps
more
  • Sequence Map
    Chr5:33897916-33936413 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      38498 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 17.83 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NELFA, negative elongation factor complex member A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NELFA, negative elongation factor complex member A
    Orthology source: HomoloGene
  • Synonyms
    NELF-A, P/OKcl.15, WHSC2
  • Links
    NCBI Gene ID: 7469
    neXtProt AC: NX_Q9H3P2

  • Chr Location
    4p16.3; chr4:1982714-2041914 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 68478
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: NELFA
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotype references
  • All Mutations and Alleles
    34
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Gene trapped
    21
  • Radiation induced
    6
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    10 involving Nelfa
  • Incidental Mutations
    APF , CvDC
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025105 VEGA Gene Model | MGI Sequence Detail 38498 C57BL/6J ±  kb
transcript OTTMUST00000061765 VEGA | MGI Sequence Detail 2580 Not Applicable  
polypeptide OTTMUSP00000030365 VEGA | MGI Sequence Detail 530 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    143 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000017419 negative elongation factor A
  • InterPro Domains
    IPR026305 Negative elongation factor A
Molecular
Reagents
less
  • All nucleic 16
    cDNA 16

    Microarray probesets 4
References
more
  • Summaries
    All 38
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 5
    Phenotypes 28
  • Earliest
    J:56621 Wright TJ, et al., Comparative analysis of a novel gene from the Wolf-Hirschhorn/Pitt-Rogers-Danks syndrome critical region. Genomics. 1999 Jul 15;59(2):203-12
  • Latest
    J:210726 Salem T, et al., Chromatin loop organization of the junb locus in mouse dendritic cells. Nucleic Acids Res. 2013 Oct;41(19):8908-25

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory