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Nelfa Gene Detail
Summary
  • Symbol
    Nelfa
  • Name
    negative elongation factor complex member A, Whsc2
  • Synonyms
    Nelf-A, Whsc2, Whsc2h
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346098
    NCBI Gene: 24116
  • Gene Overview
    MyGene.info: NELFA
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:33898179-33936258 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 17.83 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    141 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346098
protein coding gene Chr5:33897916-33936413 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029455
protein coding gene Chr5:32106321-32141616 (-)
A/J MGP_AJ_G0029422
protein coding gene Chr5:31054213-31086463 (-)
AKR/J MGP_AKRJ_G0029371
protein coding gene Chr5:32253909-32283931 (-)
BALB/cJ MGP_BALBcJ_G0029432
protein coding gene Chr5:31586060-31616008 (-)
C3H/HeJ MGP_C3HHeJ_G0029154
protein coding gene Chr5:32292730-32321980 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029886
protein coding gene Chr5:33987341-34022735 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027123
protein coding gene Chr5:28856696-28885197 (-)
CAST/EiJ MGP_CASTEiJ_G0028563
protein coding gene Chr5:31375865-31406875 (-)
CBA/J MGP_CBAJ_G0029122
protein coding gene Chr5:34717188-34747531 (-)
DBA/2J MGP_DBA2J_G0029270
protein coding gene Chr5:31235052-31264642 (-)
FVB/NJ MGP_FVBNJ_G0029229
protein coding gene Chr5:30663852-30694614 (-)
LP/J MGP_LPJ_G0029355
protein coding gene Chr5:32525113-32553900 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029259
protein coding gene Chr5:35593255-35624431 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029919
protein coding gene Chr5:31771863-31810153 (-)
PWK/PhJ MGP_PWKPhJ_G0028288
protein coding gene Chr5:30370282-30401342 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028119
protein coding gene Chr5:31216312-31246449 (-)
WSB/EiJ MGP_WSBEiJ_G0028644
protein coding gene Chr5:31847729-31876940 (-)



Homology
more
  • Human Ortholog
    NELFA, negative elongation factor complex member A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NELFA, negative elongation factor complex member A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NELF-A, P/OKcl.15, WHSC2
  • Links
    NCBI Gene ID: 7469
    neXtProt AC: NX_Q9H3P2
    UniProt: Q9H3P2

  • Chr Location
    4p16.3; chr4:1982714-2009972 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 68478
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NELFA
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotype references
  • All Mutations and Alleles
    35
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    1
  • Gene trapped
    21
  • Radiation induced
    5
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    9 involving Nelfa
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 24116 NCBI Gene Model | MGI Sequence Detail 38080 C57BL/6J ±  kb
transcript NM_011914 RefSeq | MGI Sequence Detail 2438 C57BL/6  
polypeptide Q8BG30 UniProt | EBI | MGI Sequence Detail 530 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 17

    Microarray probesets 4
References
more
  • Summaries
    All 59
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 4
    Phenotypes 30
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:210726 Salem T, et al., Chromatin loop organization of the junb locus in mouse dendritic cells. Nucleic Acids Res. 2013 Oct;41(19):8908-25

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory