Rgs7
Gene Detail

Symbol Name ID

Rgs7 regulator of G protein signaling 7 MGI:1346089

Feature Type

protein coding gene

Genetic Map

Chromosome 1

81.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr1:175059736-175491130 bp, - strand From Ensembl annotation of GRCm38   431395 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Rgs7 ± 2 cM)

Protein SuperFamily: regulator of G protein signaling, RGS7 type
Gene Tree: Rgs7

Human ortholog

RGS7 regulator of G-protein signaling 7 NCBI Gene ID 6000
Human Chr1:240938817-241520478 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Mice homozygous for a hypomorphic allele exhibit reduced exploration in a new environment, impaired glucose tolerance in males, and abnormal rod b-wave electrophysiology. Mice homozygous for a knock-out allele exhibit runting, delayed eye opening, and transient prolonged b-wave implicit time.

 

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	G-protein coupled receptor signaling pathway, intracellular signal transduction, ...
Component	cytoplasm, cytosol, ...
Function	G-protein beta-subunit binding, GTPase activator activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (182)    Tissues (22)    Images (24)
Theiler Stages: 23

Assay Type	Results
RNA in situ	182

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) cDNA(11) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000026527 (Evidence)
Entrez Gene	24012 (Evidence)
UniGene	7956
DFCI	TC1581246, TC1595644
DoTS	DT.101363024, DT.110890956, DT.110890958, DT.110890966, DT.50315270
NIA Mouse Gene Index	U022104
Consensus CDS Project	CCDS15546.1
International Mouse Knockout Project Status	Rgs7

Sequences

Length	Strain/Species
genomic	ENSMUSG00000026527	Ensembl Gene Model | MGI Sequence Detail	431395	C57BL/6J
transcript	ENSMUST00000027812	Ensembl | MGI Sequence Detail	1418	Not Applicable
polypeptide	ENSMUSP00000027812	Ensembl | MGI Sequence Detail	469	Not Applicable

All sequences(31) RefSeq(4) UniProt(6)

Polymorphisms

RFLP(1) : SNPs(2759 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000591	DEP domain
InterPro	IPR015898	G-protein gamma-like domain
InterPro	IPR024066	Regulator of G-protein signaling, domain 1
InterPro	IPR000342	Regulator of G protein signalling
InterPro	IPR016137	Regulator of G protein signalling superfamily
InterPro	IPR011991	Winged helix-turn-helix transcription repressor DNA-binding
Protein Ontology	PR:000013962	regulator of G-protein signaling 7

References

(Earliest) J:53422 He W, et al., RGS9, a GTPase accelerator for phototransduction. Neuron. 1998 Jan;20(1):95-102
(Latest) J:186321 Liapis E, et al., Subcellular localization of regulator of G protein signaling RGS7 complex in neurons and transfected cells. J Neurochem. 2012 Aug;122(3):568-81
All references(40)