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Rgs7
Gene Detail
 Symbol
Name
ID
Rgs7
regulator of G protein signaling 7
MGI:1346089
Feature Type protein coding gene
Genetic Map
Chromosome 1
81.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:175059736-175491130 bp, - strand
From Ensembl annotation of GRCm38

  431395 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2193  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: regulator of G protein signaling, RGS7 type
Gene Tree: Rgs7

Human
homologs
Human Homolog RGS7, regulator of G-protein signaling 7
NCBI Gene ID 6000
neXtProt AC  NX_P49802
Human Chr (Location)  1q43; chr1:240775514-241357230 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a hypomorphic allele exhibit reduced exploration in a new environment, impaired glucose tolerance in males, and abnormal rod b-wave electrophysiology. Mice homozygous for a knock-out allele exhibit runting, delayed eye opening, and transient prolonged b-wave implicit time.
 
Phenotype Images(1)
Interactions
Rgs7 interacts with 20 markers (Mir20a, Mir30a, Mir30d, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process G-protein coupled receptor signaling pathway, intracellular signal transduction, ...
Component cytoplasm, cytosol, ...
Function G-protein beta-subunit binding, GTPase activator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (184)    Tissues (23)    Images (25)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 182
RT-PCR 2
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(11) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000026527 (Evidence)
Entrez Gene24012 (Evidence)
UniGene7956
DFCITC1581246, TC1595644
DoTSDT.101363024, DT.110890956, DT.110890958, DT.110890966, DT.50315270
NIA Mouse Gene IndexU022104
Consensus CDS ProjectCCDS15546.1
International Mouse Knockout Project StatusRgs7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026527 Ensembl Gene Model | MGI Sequence Detail 431395 C57BL/6J ±  kb
transcript ENSMUST00000027812 Ensembl | MGI Sequence Detail 1418 Not Applicable 
polypeptide ENSMUSP00000027812 Ensembl | MGI Sequence Detail 469 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(20) UniProt(6)
Polymorphisms RFLP(1) : SNPs within 2kb(5919 from dbSNP Build 137)    SNPs within 2kb including multiple locations(5921)
Protein-related
information
ResourceIDDescription
InterPro IPR000591 DEP domain
InterPro IPR015898 G-protein gamma-like domain
InterPro IPR024066 Regulator of G-protein signaling, domain 1
InterPro IPR000342 Regulator of G protein signalling
InterPro IPR016137 Regulator of G protein signalling superfamily
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000013962 regulator of G-protein signaling 7
References (Earliest) J:53422 He W, et al., RGS9, a GTPase accelerator for phototransduction. Neuron. 1998 Jan;20(1):95-102
(Latest) J:211063 Ray TA, et al., GPR179 is required for high sensitivity of the mGluR6 signaling cascade in depolarizing bipolar cells. J Neurosci. 2014 Apr 30;34(18):6334-43
All references(42)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory