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Rgs7 Gene Detail
Summary
  • Symbol
    Rgs7
  • Name
    regulator of G protein signaling 7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346089
    NCBI Gene: 24012
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:174886653-175320066 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 81.11 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    12999 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346089
 protein coding gene Chr1:174886642-175320287 (-)
129S1/SvImJ ENSMUSG00200043464
 protein coding gene Chr1:172638187-173077790 (-)
A/J ENSMUSG00195048443
 protein coding gene Chr1:172052978-172484831 (-)
AKR/J ENSMUSG00220027681
 protein coding gene Chr1:171632170-172076497 (-)
BALB/cJ ENSMUSG00180043355
 protein coding gene Chr1:172289097-172728722 (-)
C3H/HeJ ENSMUSG00175045831
 protein coding gene Chr1:172465283-172904892 (-)
C57BL/6NJ ENSMUSG00215042491
 protein coding gene Chr1:171847396-172280847 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014942
 protein coding gene Chr1:165193553-165588841 (-)
CAST/EiJ ENSTCUG00005046297
 protein coding gene Chr1:170375186-170795454 (-)
CBA/J ENSMUSG00210041174
 protein coding gene Chr1:172108623-172538072 (-)
DBA/2J ENSMUSG00185030286
 protein coding gene Chr1:176721400-177150876 (-)
FVB/NJ ENSMUSG00205031020
 protein coding gene Chr1:171198626-171654057 (-)
JF1/MsJ ENSUMUG00000015394
 protein coding gene Chr1:175561895-175989664 (-)
LP/J ENSMUSG00230030312
 protein coding gene Chr1:176303816-176744148 (-)
NOD/ShiLtJ ENSMUSG00190027620
 protein coding gene Chr1:172139906-172579471 (-)
NZO/HlLtJ ENSMUSG00225002743
 protein coding gene Chr1:179896378-180454137 (-)
PWK/PhJ ENSLUMG00010031852
 protein coding gene Chr1:170846159-171292077 (-)
SPRET/EiJ ENSMSPG00010031258
 protein coding gene Chr1:174475909-174902715 (-)
WSB/EiJ ENSIUOG00005034740
 protein coding gene Chr1:171212124-171650172 (-)



Homology
more
  • Human Ortholog
    RGS7, regulator of G protein signaling 7
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RGS7, regulator of G protein signaling 7
  • Links
    NCBI Gene ID: 6000
    UniProt: P49802

  • Chr Location
    1q43; chr1:240767636-241357374 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    1 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic allele exhibit reduced exploration in a new environment, impaired glucose tolerance in males, and abnormal rod b-wave electrophysiology. Mice homozygous for a knock-out allele exhibit runting, delayed eye opening, and transient prolonged b-wave implicit time.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    781
  • Tissues
    23
  • cDNA Data
    12
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026527 Ensembl Gene Model | MGI Sequence Detail 433414 C57BL/6J ±  kb
    transcript ENSMUST00000195324 Ensembl | MGI Sequence Detail 2209 Not Applicable  
    polypeptide ENSMUSP00000141380 Ensembl | MGI Sequence Detail 477 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000013962 regulator of G-protein signaling 7
      (term hierarchy)
    • InterPro Domains
      IPR000591 DEP domain
      IPR036284 G-protein gamma-like domain superfamily
      IPR015898 G-protein, gamma subunit-like domain
      IPR047016 Regulator of G protein signaling 6/7/9/11
      IPR047017 Regulator of G-protein signalling 6/7/9/11, DHEX domain superfamily
      IPR040759 Regulator of G-protein signalling, DHEX domain
      IPR016137 RGS domain
      IPR036305 RGS domain superfamily
      IPR044926 RGS, subdomain 2
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    • GlyGen
      O54829 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 12
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 2
      Gene Ontology 16
      Phenotypes 25
    • Earliest
      J:53422 He W, et al., RGS9, a GTPase accelerator for phototransduction. Neuron. 1998 Jan;20(1):95-102
    • Latest
      J:352478 Pandey M, et al., Specific regulation of mechanical nociception by Gbeta5 involves GABA-B receptors. JCI Insight. 2023 Jul 10;8(13)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory