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Rgs7 Gene Detail
Summary
  • Symbol
    Rgs7
  • Name
    regulator of G protein signaling 7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346089
    NCBI Gene: 24012
Location & Maps
more
  • Sequence Map
    Chr1:175059087-175492500 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      433414 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    RGS7, regulator of G-protein signaling 7
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RGS7, regulator of G-protein signaling 7
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 6000
    neXtProt AC: NX_P49802

  • Chr Location
    1q43; chr1:240775514-241357230 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 3 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    1 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Rgs7
  • Incidental Mutations
Mice homozygous for a hypomorphic allele exhibit reduced exploration in a new environment, impaired glucose tolerance in males, and abnormal rod b-wave electrophysiology. Mice homozygous for a knock-out allele exhibit runting, delayed eye opening, and transient prolonged b-wave implicit time.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050245 VEGA Gene Model | MGI Sequence Detail 433414 C57BL/6J ±  kb
transcript OTTMUST00000127637 VEGA | MGI Sequence Detail 2209 Not Applicable  
polypeptide OTTMUSP00000068825 VEGA | MGI Sequence Detail 477 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    5927 from dbSNP Build 137
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 13
    cDNA 11
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 40
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 13
  • Earliest
    J:53422 He W, et al., RGS9, a GTPase accelerator for phototransduction. Neuron. 1998 Jan;20(1):95-102
  • Latest
    J:221107 Sarria I, et al., Sensitivity and kinetics of signal transmission at the first visual synapse differentially impact visually-guided behavior. Elife. 2015;4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory