About   Help   FAQ
Cd52 Gene Detail
Summary
  • Symbol
    Cd52
  • Name
    CD52 antigen
  • Synonyms
    B7, CAMPATH-1, CLS1, MB7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346088
    NCBI Gene: 23833
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:133820849-133822384 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 4, 66.50 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    35 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346088
protein coding gene Chr4:133809759-133822393 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028911
protein coding gene Chr4:136415223-136428028 (-)
A/J MGP_AJ_G0028870
protein coding gene Chr4:130667985-130681680 (-)
AKR/J MGP_AKRJ_G0028822
protein coding gene Chr4:134416592-134431002 (-)
BALB/cJ MGP_BALBcJ_G0028893
protein coding gene Chr4:131320083-131332509 (-)
C3H/HeJ MGP_C3HHeJ_G0028607
protein coding gene Chr4:134651543-134665640 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029335
protein coding gene Chr4:141321006-141333608 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026606
protein coding gene Chr4:123733328-123746295 (-)
CAST/EiJ MGP_CASTEiJ_G0028040
protein coding gene Chr4:132771273-132788645 (-)
CBA/J MGP_CBAJ_G0028572
protein coding gene Chr4:145031336-145048912 (-)
DBA/2J MGP_DBA2J_G0028721
protein coding gene Chr4:131103205-131115631 (-)
FVB/NJ MGP_FVBNJ_G0028689
protein coding gene Chr4:129993537-130006911 (-)
LP/J MGP_LPJ_G0028822
protein coding gene Chr4:136498259-136510904 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028714
protein coding gene Chr4:149534532-149546958 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029373
protein coding gene Chr4:134841629-134854128 (-)
PWK/PhJ MGP_PWKPhJ_G0027760
protein coding gene Chr4:127829062-127846763 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027586
protein coding gene Chr4:130683952-130697738 (-)
WSB/EiJ MGP_WSBEiJ_G0028119
protein coding gene Chr4:135022926-135040771 (-)



Homology
more
  • Human Ortholog
    CD52, CD52 molecule
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD52, CD52 molecule
  • Synonyms
    CDW52, EDDM5, HE5
  • Links
    NCBI Gene ID: 1043
    neXtProt AC: NX_P31358
    UniProt: P31358

  • Chr Location
    1p36.11; chr1:26317958-26320523 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
  • All Mutations and Alleles
    21
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    7
  • Gene trapped
    5
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    4 involving Cd52
  • Find Mice (IMSR)
Mice homozygous for a null mutation are viable with no gross abnormalities and no defects in sperm development or function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 23833 NCBI Gene Model | MGI Sequence Detail 1536 C57BL/6J ±  kb
transcript NM_013706 RefSeq | MGI Sequence Detail 531 ZRU/MplStud  
polypeptide Q64389 UniProt | EBI | MGI Sequence Detail 74 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 41
    cDNA 40
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2140299
References
more
  • Summaries
    All 48
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:10835 Kubota H, et al., Identification and gene cloning of a new phosphatidylinositol-linked antigen expressed on mature lymphocytes. Down-regulation by lymphocyte activation. J Immunol. 1990 Dec 1;145(11):3924-31
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory