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Insl5
Gene Detail
Symbol

Name
ID
Insl5
insulin-like 5
MGI:1346085
Synonyms
relaxin/insulin-like factor 2, RIF2
Feature Type
protein coding gene
Genetic Map
Chromosome 4
47.27 cM, cytoband C5-C7
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:103017872-103026842 bp, - strand
From VEGA annotation of GRCm38

  8971 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48350  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Protein SuperFamily: relaxin-3/insulin-like peptide 5
Gene Tree: Insl5

Human
homologs
Human Homolog INSL5, insulin-like 5
NCBI Gene ID 10022
neXtProt AC  NX_Q9Y5Q6
Human Synonyms  PRO182, UNQ156
Human Chr (Location)  1p31.3; chr1:66797741-66801259 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation display no abnormal phenotype. Mice homozygous for a different knock-out allele exhibit background sensitive reduction in fertility due to reduced sperm motility and irregular estrous cycle and impairment in glucose tolerance due to reduced insulin levels.
 
Interactions
Insl5 interacts with 60 markers (Mir25, Mir32, Mir92-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Component extracellular region
Function hormone activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (50)    Tissues (48)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 15
RT-PCR 35
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) Genomic(1) cDNA(7) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000008072 (Evidence)
Ensembl Gene ModelENSMUSG00000066090 (Evidence)
Entrez Gene23919 (Evidence)
UniGene100163
DFCITC1586403
DoTSDT.529970, DT.91335618
NIA Mouse Gene IndexU025309
Consensus CDS ProjectCCDS18406.1, CCDS71431.1
International Mouse Knockout Project StatusInsl5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008072 VEGA Gene Model | MGI Sequence Detail 8971 C57BL/6J ±  kb
transcript OTTMUST00000018317 VEGA | MGI Sequence Detail 438 Not Applicable 
polypeptide OTTMUSP00000008427 VEGA | MGI Sequence Detail 145 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(102 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022353 Insulin, conserved site
InterPro IPR016179 Insulin-like
Protein Ontology PR:000009060 insulin-like peptide INSL5
References
(Earliest) J:57249 Conklin D, et al., Identification of INSL5, a new member of the insulin superfamily. Genomics. 1999 Aug 15;60(1):50-6
(Latest) J:200797 Mashima H, et al., INSL5 may be a unique marker of colorectal endocrine cells and neuroendocrine tumors. Biochem Biophys Res Commun. 2013 Mar 22;432(4):586-92
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory