Insl5
Gene Detail

Symbol Name ID

Insl5 insulin-like 5 MGI:1346085

Synonyms

relaxin/insulin-like factor 2, RIF2

Feature Type

protein coding gene

Genetic Map

Chromosome 4

47.27 cM, cytoband C5-C7
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr4:103017872-103026842 bp, - strand From VEGA annotation of GRCm38   8971 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; cattle; chimpanzee    (Mammalian Orthology)
Comparative Map (Mouse/Human Insl5 ± 2 cM)

Protein SuperFamily: relaxin-3/insulin-like peptide 5
Gene Tree: Insl5

Human ortholog

INSL5 insulin-like 5 NCBI Gene ID 10022
Human Synonyms: PRO182, UNQ156
Human Chr1:67263424-67266939 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a targeted mutation display no abnormal phenotype. Mice homozygous for a different knock-out allele exhibit background sensitive reduction in fertility due to reduced sperm motility and irregular estrous cycle and impairment in glucose tolerance due to reduced insulin levels.

 

Gene Ontology (GO) classifications

All GO classifications: (4 annotations)

Component	extracellular region
Function	hormone activity

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (50)    Tissues (46)    Images (9)
Theiler Stages: 22, 24, 26, 28

Assay Type	Results
RNA in situ	15
RT-PCR	35

cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(9) Genomic(1) cDNA(7) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000008072 (Evidence)
Ensembl Gene Model	ENSMUSG00000066090 (Evidence)
Entrez Gene	23919 (Evidence)
UniGene	100163
DFCI	TC1586403
DoTS	DT.529970, DT.91335618
NIA Mouse Gene Index	U025309
Consensus CDS Project	CCDS18406.1
International Mouse Knockout Project Status	Insl5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008072	VEGA Gene Model | MGI Sequence Detail	8971	C57BL/6J
transcript	OTTMUST00000018317	VEGA | MGI Sequence Detail	438	Not Applicable
polypeptide	OTTMUSP00000008427	VEGA | MGI Sequence Detail	145	Not Applicable

All sequences(29) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(68 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR022353	Insulin, conserved site
InterPro	IPR016179	Insulin-like
Protein Ontology	PR:000009060	insulin-like peptide INSL5

References

(Earliest) J:57249 Conklin D, et al., Identification of INSL5, a new member of the insulin superfamily. Genomics. 1999 Aug 15;60(1):50-6
(Latest) J:189146 Burnicka-Turek O, et al., INSL5-deficient mice display an alteration in glucose homeostasis and an impaired fertility. Endocrinology. 2012 Oct;153(10):4655-65
All references(31)