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Insl5
Gene Detail
Symbol

Name
ID
Insl5
insulin-like 5
MGI:1346085
Synonyms
relaxin/insulin-like factor 2, RIF2
Feature Type
protein coding gene
Genetic Map
Chromosome 4
47.27 cM, cytoband C5-C7
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:103017872-103026842 bp, - strand
From VEGA annotation of GRCm38

  8971 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48350  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle

HCOP human homology predictions: INSL5
Protein SuperFamily: relaxin-3/insulin-like peptide 5
Gene Tree: Insl5

Human
homologs
INSL5, insulin-like 5
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10022
neXtProt AC: NX_Q9Y5Q6

Human Synonyms: PRO182, UNQ156

Human Chr (Location): 1p31.3; chr1:66797741-66801259 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Genomic Mutations involving Insl5 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation display no abnormal phenotype. Mice homozygous for a different knock-out allele exhibit background sensitive reduction in fertility due to reduced sperm motility and irregular estrous cycle and impairment in glucose tolerance due to reduced insulin levels.
 
Interactions
Insl5 interacts with 60 markers (Mir25, Mir32, Mir92-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process positive regulation of feeding behavior
Component extracellular region
Function hormone activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (50)    Tissues (48)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 15
RT-PCR 35
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN insl5a, insl5b    NEW 
Molecular
reagents
All nucleic(9) Genomic(1) cDNA(7) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000008072 (Evidence)
Ensembl Gene Model ENSMUSG00000066090 (Evidence)
Entrez Gene 23919 (Evidence)
UniGene 100163
DFCI TC1586403
DoTS DT.91335618, DT.529970
NIA Mouse Gene Index U025309
Consensus CDS Project CCDS18406.1, CCDS71431.1
International Mouse Phenotyping Consortium Status Insl5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008072 VEGA Gene Model | MGI Sequence Detail 8971 C57BL/6J ±  kb
transcript OTTMUST00000018317 VEGA | MGI Sequence Detail 438 Not Applicable 
polypeptide OTTMUSP00000008427 VEGA | MGI Sequence Detail 145 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(102 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022353 Insulin, conserved site
InterPro IPR016179 Insulin-like
Protein Ontology PR:000009060 insulin-like peptide INSL5
References
(Earliest) J:57249 Conklin D, et al., Identification of INSL5, a new member of the insulin superfamily. Genomics. 1999 Aug 15;60(1):50-6
(Latest) J:212239 Grosse J, et al., Insulin-like peptide 5 is an orexigenic gastrointestinal hormone. Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11133-8
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory