Mmp17
Gene Detail

Symbol Name ID

Mmp17 matrix metallopeptidase 17 MGI:1346076

Synonyms

membrane type-4 matrix metalloproteinase, MT4-MMP

Feature Type

protein coding gene

Genetic Map

Chromosome 5

68.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr5:129584169-129608875 bp, + strand From VEGA annotation of GRCm38   24707 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22669  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp17

Human homologs

Human Homolog		MMP17, matrix metallopeptidase 17 (membrane-inserted)
NCBI Gene ID		4326
neXtProt AC		NX_Q9ULZ9
Human Synonyms		MT4-MMP
Human Chr (Location)		12q24.3; chr12:132312941-132336316 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for a reporter allele exhibit normal morphology, clinical chemistry, hematology and behavior. Mice homozygous for a reporter/null allele exhibit normal growth, fertility, and lifespan but show subtle renal developmental defects, hypodipsia, and elevated urine osmolarity.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	proteolysis
Component	anchored to membrane, extracellular matrix, ...
Function	calcium ion binding, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (251)    Tissues (97)    Images (115)
Theiler Stages: 23, 24, 28

Assay Type	Results
RNA in situ	63
In situ reporter (knock in)	145
RT-PCR	43

cDNA source data(21)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(25) cDNA(21) Primer pair(3) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000042407 (Evidence)
Ensembl Gene Model	ENSMUSG00000029436 (Evidence)
Entrez Gene	23948 (Evidence)
UniGene	42047
DFCI	TC1579514, TC1651211
DoTS	DT.40174543
NIA Mouse Gene Index	U006229
EC	3.4.24.-
Consensus CDS Project	CCDS19695.1
International Mouse Knockout Project Status	Mmp17

Sequences

Length	Strain/Species
genomic	OTTMUSG00000042407	VEGA Gene Model | MGI Sequence Detail	24707	C57BL/6J
transcript	OTTMUST00000111796	VEGA | MGI Sequence Detail	4198	Not Applicable
polypeptide	OTTMUSP00000062676	VEGA | MGI Sequence Detail	578	Not Applicable

All sequences(23) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(152 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000585	Hemopexin/matrixin
InterPro	IPR018487	Hemopexin/matrixin, repeat
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR021190	Peptidase M10A, matrix metallopeptidase
InterPro	IPR016293	Peptidase M10A, matrix metallopeptidase, stromelysin type
InterPro	IPR001818	Peptidase M10, metallopeptidase
InterPro	IPR006026	Peptidase, metallopeptidase
InterPro	IPR002477	Peptidoglycan binding-like
Protein Ontology	PR:000010477	matrix metalloproteinase-17

References

(Earliest) J:57454 Kajita M, et al., Human membrane type-4 matrix metalloproteinase (MT4-MMP) is encoded by a novel major transcript: isolation of complementary DNA clones for human and mouse mt4-mmp transcripts. FEBS Lett. 1999 Sep 3;457(3):353-6
(Latest) J:171096 Srichai MB, et al., Membrane-type 4 matrix metalloproteinase (MT4-MMP) modulates water homeostasis in mice. PLoS One. 2011;6(2):e17099
All references(34)