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Mmp17
Gene Detail
 Symbol
Name
ID
Mmp17
matrix metallopeptidase 17
MGI:1346076
Synonyms membrane type-4 matrix metalloproteinase, MT4-MMP
Feature Type protein coding gene
Genetic Map
Chromosome 5
68.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:129584169-129608875 bp, + strand
From VEGA annotation of GRCm38

  24707 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22669  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp17

Human
homologs
Human Homolog MMP17, matrix metallopeptidase 17 (membrane-inserted)
NCBI Gene ID 4326
neXtProt AC  NX_Q9ULZ9
Human Synonyms  MT4-MMP
Human Chr (Location)  12q24.3; chr12:131828396-131851771 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a reporter allele exhibit normal morphology, clinical chemistry, hematology and behavior. Mice homozygous for a reporter/null allele exhibit normal growth, fertility, and lifespan but show subtle renal developmental defects, hypodipsia, and elevated urine osmolarity.
 
Interactions
Mmp17 interacts with 259 markers (Mir1b, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process proteolysis
Component anchored component of membrane, extracellular matrix, ...
Function calcium ion binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (251)    Tissues (97)    Images (115)
Theiler Stages: 23, 24, 28
Assay TypeResults
RNA in situ 63
In situ reporter (knock in) 145
RT-PCR 43
cDNA source data(21)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) cDNA(21) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000042407 (Evidence)
Ensembl Gene ModelENSMUSG00000029436 (Evidence)
Entrez Gene23948 (Evidence)
UniGene42047
DFCITC1579514, TC1651211
DoTSDT.40174543
NIA Mouse Gene IndexU006229
EC3.4.24.-
Consensus CDS ProjectCCDS19695.1
International Mouse Knockout Project StatusMmp17
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042407 VEGA Gene Model | MGI Sequence Detail 24707 C57BL/6J ±  kb
transcript OTTMUST00000111796 VEGA | MGI Sequence Detail 4198 Not Applicable 
polypeptide OTTMUSP00000062676 VEGA | MGI Sequence Detail 578 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(196 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000585 Hemopexin-like domain
InterPro IPR018487 Hemopexin-like repeats
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR021190 Peptidase M10A
InterPro IPR016293 Peptidase M10A, metazoans
InterPro IPR001818 Peptidase M10, metallopeptidase
InterPro IPR006026 Peptidase, metallopeptidase
InterPro IPR002477 Peptidoglycan binding-like
Protein Ontology PR:000010477 matrix metalloproteinase-17
References (Earliest) J:57454 Kajita M, et al., Human membrane type-4 matrix metalloproteinase (MT4-MMP) is encoded by a novel major transcript: isolation of complementary DNA clones for human and mouse mt4-mmp transcripts. FEBS Lett. 1999 Sep 3;457(3):353-6
(Latest) J:196080 Elsen GE, et al., The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4081-6
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory