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Fxr2 Gene Detail
Summary
  • Symbol
    Fxr2
  • Name
    fragile X mental retardation, autosomal homolog 2
  • Synonyms
    Fxr2h
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346074
    NCBI Gene: 23879
  • Gene Overview
    MyGene.info: FXR2
Location & Maps
more
  • Sequence Map
    Chr11:69632990-69653297 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20308 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.86 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    FXR2, FMR1 autosomal homolog 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    FXR2, FMR1 autosomal homolog 2
    Orthology source: HomoloGene
  • Synonyms
    FMR1L2, FXR2P
  • Links
    NCBI Gene ID: 9513
    neXtProt AC: NX_P51116

  • Chr Location
    17p13.1; chr17:7591230-7614897 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (other)
    1
  • Gene trapped
    7
  • Targeted
    7
  • Genomic Mutations
    2 involving Fxr2
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit hyperactivity, impaired Morris water task performance, and reductions in prepulse inhibition, contextual conditioned fear, and sensitivity to heat stimulus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006005 VEGA Gene Model | MGI Sequence Detail 20308 C57BL/6J ±  kb
transcript OTTMUST00000013449 VEGA | MGI Sequence Detail 2951 Not Applicable  
polypeptide OTTMUSP00000006226 VEGA | MGI Sequence Detail 674 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    123 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000003391 fragile X mental retardation syndrome-related protein 2
  • InterPro Domains
    IPR008395 Agenet-like domain
    IPR022034 Fragile X-related 1 protein, C-terminal core
    IPR032172 Fragile X-related 1 protein, C-terminal region 1
    IPR004087 K Homology domain
    IPR004088 K Homology domain, type 1
Molecular
Reagents
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  • All nucleic 89
    Genomic 1
    cDNA 87
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 47
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 24
  • Earliest
    J:57450 Miyashita A, et al., Five different genes, Eif4a1, Cd68, Supl15h, Sox15 and Fxr2h, are clustered in a 40 kb region of mouse chromosome 11. Gene. 1999 Sep 3;237(1):53-60
  • Latest
    J:228704 Guo W, et al., Fragile X Proteins FMRP and FXR2P Control Synaptic GluA1 Expression and Neuronal Maturation via Distinct Mechanisms. Cell Rep. 2015 Jun 16;11(10):1651-66

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory