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Dlgap1 Gene Detail
Summary
  • Symbol
    Dlgap1
  • Name
    DLG associated protein 1
  • Synonyms
    4933422O14Rik, D17Bwg0511e, DAP-1 beta, Gkap, GKAP/SAPAP, Sapap1, SAPAP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346065
    NCBI Gene: 224997
  • Alliance
    gene page
  • Transcription Start Sites
    33 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:70276068-71128408 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 40.85 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6684 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346065
 protein coding gene Chr17:70276068-71128408 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023999
 protein coding gene Chr17:72326666-73229732 (+)
A/J MGP_AJ_G0023957
 protein coding gene Chr17:70119448-70995048 (+)
AKR/J MGP_AKRJ_G0023926
 protein coding gene Chr17:71120926-71975208 (+)
BALB/cJ MGP_BALBcJ_G0023958
 protein coding gene Chr17:70067599-70924208 (+)
C3H/HeJ MGP_C3HHeJ_G0023722
 protein coding gene Chr17:72039179-72923440 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024404
 protein coding gene Chr17:74946546-75888875 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021850
 protein coding gene Chr17:65958187-66784471 (+)
CAST/EiJ MGP_CASTEiJ_G0023203
 protein coding gene Chr17:72463603-73348048 (+)
CBA/J MGP_CBAJ_G0023697
 protein coding gene Chr17:78044102-79048399 (+)
DBA/2J MGP_DBA2J_G0023826
 protein coding gene Chr17:68847790-69688493 (+)
FVB/NJ MGP_FVBNJ_G0023792
 protein coding gene Chr17:68301738-69151223 (+)
LP/J MGP_LPJ_G0023908
 protein coding gene Chr17:73096252-73981032 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023820
 protein coding gene Chr17:78001629-78950421 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024448
 protein coding gene Chr17:71617371-72492568 (+)
PWK/PhJ MGP_PWKPhJ_G0022949
 protein coding gene Chr17:68142827-68989806 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022760
 protein coding gene Chr17:68341175-69206724 (+)
WSB/EiJ MGP_WSBEiJ_G0023270
 protein coding gene Chr17:72383669-73292058 (+)



Homology
more
  • Human Ortholog
    DLGAP1, DLG associated protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DLGAP1, DLG associated protein 1
  • Synonyms
    DAP1, DAP-1, DAP-1-ALPHA, DAP-1-BETA, DLGAP1A, DLGAP1B, GKAP, SAPAP1
  • Links
    NCBI Gene ID: 9229
    neXtProt AC: NX_O14490
    UniProt: O14490

  • Chr Location
    18p11.31; chr18:3496032-4455307 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit deficits in sociability.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    3
  • cDNA Data
    19
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 224997 NCBI Gene Model | MGI Sequence Detail 852341 C57BL/6J ±  kb
    transcript NM_001360665 RefSeq | MGI Sequence Detail 7282 ZRU/MplStud  
    polypeptide Q9D415 UniProt | EBI | MGI Sequence Detail 992 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 19
      Primer pair 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGD-MRK-33093, MGI:105421, MGI:1330231, MGI:1918442, MGI:2146933, MGI:2146937, MGI:2147105
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 5
      Gene Ontology 9
      Phenotypes 9
    • Earliest
      J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
    • Latest
      J:342803 Horner AE, et al., Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2. Genes Brain Behav. 2021 Jan;20(1):e12723
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory