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Dlgap1 Gene Detail
Summary
  • Symbol
    Dlgap1
  • Name
    discs, large (Drosophila) homolog-associated protein 1
  • Synonyms
    4933422O14Rik, D17Bwg0511e, DAP-1 beta, Gkap, GKAP/SAPAP, Sapap1, SAPAP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346065
    NCBI Gene: 224997
  • Gene Overview
    MyGene.info: DLGAP1
Location & Maps
more
  • Sequence Map
    Chr17:69969073-70821413 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      852341 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 40.85 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DLGAP1, DLG associated protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DLGAP1, DLG associated protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DAP1, DAP-1, DAP-1-ALPHA, DAP-1-BETA, DLGAP1A, DLGAP1B, GKAP, SAPAP1
  • Links
    NCBI Gene ID: 9229
    neXtProt AC: NX_O14490

  • Chr Location
    18p11.31; chr18:3496032-4455310 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033115 VEGA Gene Model | MGI Sequence Detail 852341 C57BL/6J ±  kb
transcript OTTMUST00000082774 VEGA | MGI Sequence Detail 4712 Not Applicable  
polypeptide OTTMUSP00000044408 VEGA | MGI Sequence Detail 992 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    6684 from dbSNP Build 142
Protein
Information
less
  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000006516 disks large-associated protein 1
  • InterPro Domains
    IPR030524 Disks large-associated protein 1
    IPR005026 SAPAP family
Molecular
Reagents
less
  • All nucleic 18
    cDNA 17
    Primer pair 1

    Microarray probesets 10
Other
Accession IDs
less
MGD-MRK-33093, MGI:105421, MGI:1330231, MGI:1918442, MGI:2146933, MGI:2146937, MGI:2147105
References
more
  • Summaries
    All 39
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 4
  • Earliest
    J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
  • Latest
    J:197297 Moutin E, et al., GKAP-DLC2 interaction organizes the postsynaptic scaffold complex to enhance synaptic NMDA receptor activity. J Cell Sci. 2012 Apr 15;125(Pt 8):2030-40

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory