Eci2 MGI Mouse Gene Detail - MGI:1346064 - enoyl-Coenzyme A delta isomerase 2

Symbol

Eci2
Name

enoyl-Coenzyme A delta isomerase 2
Synonyms

ACBD2, DRS1, HCA88, Peci

Feature Type

protein coding gene
IDs

MGI:1346064
NCBI Gene: 23986
Gene Overview

MyGene.info: ECI2
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr13:34977748-35027096 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 14.23 cM, cytoband A4
Mapping Data

2 experiments

SNPs within 2kb

172 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346064	protein coding gene	Chr13:34977748-35027115 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020457	protein coding gene	Chr13:33123236-33144005 (-)
A/J	MGP_AJ_G0020411	protein coding gene	Chr13:32102680-32153635 (-)
AKR/J	MGP_AKRJ_G0020389	protein coding gene	Chr13:32897912-32926506 (-)
BALB/cJ	MGP_BALBcJ_G0020407	protein coding gene	Chr13:32199304-32246301 (-)
C3H/HeJ	MGP_C3HHeJ_G0020206	protein coding gene	Chr13:32826000-32873686 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020839	protein coding gene	Chr13:34265440-34333637 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018427	protein coding gene	Chr13:30434367-30450708 (-)
CAST/EiJ	MGP_CASTEiJ_G0019721	protein coding gene	Chr13:32510843-32530602 (-)
CBA/J	MGP_CBAJ_G0020167	protein coding gene	Chr13:35731782-35756614 (-)
DBA/2J	MGP_DBA2J_G0020289	protein coding gene	Chr13:31671931-31726829 (-)
FVB/NJ	MGP_FVBNJ_G0020268	protein coding gene	Chr13:31232930-31249950 (-)
LP/J	MGP_LPJ_G0020364	protein coding gene	Chr13:33376052-33402522 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020298	protein coding gene	Chr13:35841995-35910019 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020883	protein coding gene	Chr13:32527342-32567216 (-)
PWK/PhJ	MGP_PWKPhJ_G0019476	protein coding gene	Chr13:31798615-31815960 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019303	protein coding gene	Chr13:31183581-31218540 (-)
WSB/EiJ	MGP_WSBEiJ_G0019783	protein coding gene	Chr13:32917783-32934637 (-)

Human Ortholog

ECI2, enoyl-CoA delta isomerase 2

Vertebrate Orthologs

10

Human Ortholog

ECI2, enoyl-CoA delta isomerase 2
Orthology source: HomoloGene, HGNC
Synonyms

ACBD2, dJ1013A10.3, DRS1, DRS-1, HCA88, PECI
Links

HGNC:14601

NCBI Gene ID: 10455

neXtProt AC: NX_O75521

UniProt: O75521
Chr Location

6p25.2; chr6:4115693-4135597 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 38145
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: ECI2
Protein SuperFamily

4-chlorobenzoate-CoA dehalogenase 30K chain
Gene Tree

Eci2

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Phenotype Summary

13 phenotype references

All Mutations and Alleles

8
Chemically induced (other)

1
Gene trapped

2
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Eci2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available

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All GO Annotations

20
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

802
Tissues

149
cDNA Data

148
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase eci2

ZFIN eci2

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Eci2 interacts with 29 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

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All Sequences

90
RefSeq

23
UniProt

8
CCDS

CCDS26450.1, CCDS49234.1
UniGene

491141

Ensembl

ENSMUSG00000021417 (Evidence)
NCBI Gene

23986

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021417	Ensembl Gene Model \| MGI Sequence Detail	49349	C57BL/6J	± kb
transcript	ENSMUST00000171229	Ensembl \| MGI Sequence Detail	1426	Not Applicable
polypeptide	ENSMUSP00000131735	Ensembl \| MGI Sequence Detail	391	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000012534 enoyl-CoA Delta isomerase 2, mitochondrial

(term hierarchy)
EC

5.3.3.8
InterPro Domains

IPR000582 Acyl-CoA-binding protein, ACBP

IPR022408 Acyl-CoA-binding protein, ACBP, conserved site

IPR035984 Acyl-CoA binding protein superfamily

IPR029045 ClpP/crotonase-like domain superfamily

IPR014748 Enoyl-CoA hydratase, C-terminal

IPR001753 Enoyl-CoA hydratase/isomerase

IPR014352 FERM/acyl-CoA-binding protein superfamily

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All nucleic 150

cDNA 149

Primer pair 1

Microarray probesets 3

Summaries

All 45

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 13
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:211485 van Weeghel M, et al., Identification and characterization of Eci3, a murine kidney-specific Delta3,Delta2-enoyl-CoA isomerase. FASEB J. 2014 Mar;28(3):1365-74

TSS for Eci2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr122082	Chr13:35027077-35027099 (-)	8 bp
Tssr122081	Chr13:35027033-35027055 (-)	52 bp
Tssr122080	Chr13:34994103-34994148 (-)	32,970 bp
Tssr122079	Chr13:34994062-34994086 (-)	33,022 bp
Tssr122078	Chr13:34993873-34993914 (-)	33,202 bp
Tssr122077	Chr13:34993228-34993246 (-)	33,859 bp
Tssr122076	Chr13:34993196-34993219 (-)	33,888 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 03/03/2020 MGI 6.15