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Ggt5
Gene Detail
 Symbol
Name
ID
Ggt5
gamma-glutamyltransferase 5
MGI:1346063
Synonyms gamma-glutamyl leukotrienase, GGL, Ggtla1, GGT-REL
Feature Type protein coding gene
Genetic Map
Chromosome 10
38.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:75589381-75616968 bp, + strand
From NCBI annotation of GRCm38

  27588 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55802  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Ggt5

Human
homologs
Human Homolog GGT5, gamma-glutamyltransferase 5
NCBI Gene ID 2687
neXtProt AC  NX_P36269
Human Synonyms  GGTLA1, GGT-REL
Human Chr (Location)  22q11.23; chr22:24219654-24245142 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants show an attenuation in neutrophil recruitment in an experimental model of peritonitis.
 
Interactions
Ggt5 interacts with 225 markers (Mir10a, Mir10b, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process glutathione biosynthetic process, glutathione metabolic process, ...
Component integral component of membrane, membrane, ...
Function gamma-glutamyltransferase activity, glutathione hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(19)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000006344 (Evidence)
Entrez Gene23887 (Evidence)
UniGene257927
DFCITC1583315
DoTSDT.101367634, DT.110596813, DT.527125
NIA Mouse Gene IndexU011663
EC2.3.2.2, 3.4.19.13, 3.4.19.14
Consensus CDS ProjectCCDS23928.1
International Mouse Knockout Project StatusGgt5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 23887 NCBI Gene Model | MGI Sequence Detail 27588 C57BL/6J ±  kb
transcript NM_011820 RefSeq | MGI Sequence Detail 4137 C57BL/6 
polypeptide Q9Z2A9 UniProt | EBI | MGI Sequence Detail 573 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(8) UniProt(3)
Polymorphisms SNPs within 2kb(199 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000101 Gamma-glutamyltranspeptidase
Protein Ontology PR:000007963 gamma-glutamyltransferase 5
Graphical View of Protein Domain Structure
References (Earliest) J:50497 Carter BZ, et al., gamma-glutamyl leukotrienase, a gamma-glutamyl transpeptidase gene family member, is expressed primarily in spleen. J Biol Chem. 1998 Oct 23;273(43):28277-85
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(36)
Other
accession IDs
MGI:2143643

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory