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Mgll Gene Detail
Summary
  • Symbol
    Mgll
  • Name
    monoglyceride lipase
  • Synonyms
    Magl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346042
    NCBI Gene: 23945
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:88724412-88828360 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      103949 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 39.51 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    MGLL, monoglyceride lipase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MGLL, monoglyceride lipase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HUK5, HU-K5, MAGL, MGL
  • Links
    NCBI Gene ID: 11343
    neXtProt AC: NX_Q99685
    UniProt: Q99685

  • Chr Location
    3q21.3; chr3:127689062-127823250 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 2 alleles in 2 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit hypoalgesia, increased body temperature, and decreased fatty acid levels. Mice homozygous for a targeted allele exhibit impaired lipolysis and improved glucose homeostasis on a high-fat diet.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000023902 VEGA Gene Model | MGI Sequence Detail 103949 C57BL/6J ±  kb
    transcript OTTMUST00000058400 VEGA | MGI Sequence Detail 1308 Not Applicable  
    polypeptide OTTMUSP00000028287 VEGA | MGI Sequence Detail 331 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      464 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 142
      cDNA 140
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1889369
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 10
      Gene Ontology 9
      Phenotypes 24
    • Earliest
      J:51746 Karlsson M, et al., cDNA cloning, tissue distribution, and identification of the catalytic triad of monoglyceride lipase. Evolutionary relationship to esterases, lysophospholipases, and haloperoxidases. J Biol Chem. 1997 Oct 24;272(43):27218-23
    • Latest
      J:241351 Lu J, et al., The phosphorylation status of T522 modulates tissue-specific functions of SIRT1 in energy metabolism in mice. EMBO Rep. 2017 May;18(5):841-857

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory