About   Help   FAQ
Mgll
Gene Detail
Symbol

Name
ID
Mgll
monoglyceride lipase
MGI:1346042
Synonyms
Magl
Feature Type
protein coding gene
Genetic Map
Chromosome 6
39.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr6:88724412-88828360 bp, + strand
From VEGA annotation of GRCm38

  103949 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38298  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: monoglyceride lipase/lysophospholipase
Gene Tree: Mgll

Human
homologs
Human Homolog MGLL, monoglyceride lipase
NCBI Gene ID 11343
neXtProt AC  NX_Q99685
Human Synonyms  HUK5, HU-K5, MAGL, MGL
Human Chr (Location)  3q21.3; chr3:127689062-127823250 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(3) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trapped allele exhibit hypoalgesia, increased body temperature, and decreased fatty acid levels. Mice homozygous for a targeted allele exhibit impaired lipolysis and improved glucose homeostasis on a high-fat diet.
 
Interactions
Mgll interacts with 297 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process acylglycerol catabolic process, arachidonic acid metabolic process, ...
Component axon, nucleoplasm, ...
Function acylglycerol lipase activity, carboxylic ester hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (215)    Tissues (111)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 215
cDNA source data(139)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(141) cDNA(139) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000023902 (Evidence)
Ensembl Gene ModelENSMUSG00000033174 (Evidence)
Entrez Gene23945 (Evidence)
UniGene272197
DFCITC1572472, TC1643947, TC1646487, TC1604942, TC1607238, TC1582956
DoTSDT.94374198, DT.101402512, DT.101402518, DT.94374191, DT.94347049, DT.55216476, DT.110495034
NIA Mouse Gene IndexU007150
EC3.1.1.23
Consensus CDS ProjectCCDS20338.1, CCDS51843.1, CCDS51844.1
International Mouse Knockout Project StatusMgll
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023902 VEGA Gene Model | MGI Sequence Detail 103949 C57BL/6J ±  kb
transcript OTTMUST00000058400 VEGA | MGI Sequence Detail 1237 Not Applicable 
polypeptide OTTMUSP00000028287 VEGA | MGI Sequence Detail 331 Not Applicable 

For the selected sequences
All sequences(150) RefSeq(8) UniProt(9)
Polymorphisms
RFLP(1) : SNPs within 2kb(474 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000073 Alpha/beta hydrolase fold-1
InterPro IPR022742 Alpha/beta hydrolase, N-terminal
Protein Ontology PR:000010387 monoglyceride lipase
References
(Earliest) J:51746 Karlsson M, et al., cDNA cloning, tissue distribution, and identification of the catalytic triad of monoglyceride lipase. Evolutionary relationship to esterases, lysophospholipases, and haloperoxidases. J Biol Chem. 1997 Oct 24;272(43):27218-23
(Latest) J:207678 Ohno H, et al., EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex. Nature. 2013 Dec 5;504(7478):163-7
All references(56)
Other
accession IDs
MGI:1889369

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory