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Insrr Gene Detail
Summary
  • Symbol
    Insrr
  • Name
    insulin receptor-related receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346037
    NCBI Gene: 23920
  • Gene Overview
    MyGene.info: INSRR
Location & Maps
more
  • Sequence Map
    Chr3:87796951-87816101 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19151 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 38.70 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    INSRR, insulin receptor related receptor
  • Vertebrate Orthologs
    8
  • Human Ortholog
    INSRR, insulin receptor related receptor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IRR
  • Links
    NCBI Gene ID: 3645
    neXtProt AC: NX_P14616

  • Chr Location
    1q21-q23; chr1:156840873-156858920 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    8 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Insrr
  • Incidental Mutations
Mice homozygous for a targeted null mutation exhibit no anomalies in pancreatic islet morphology, beta-cell mass or pancreatic secretory function. This mutation in combination with Insr mutant mice does not affect the diabetes predisposition of Insr mutant mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035156 VEGA Gene Model | MGI Sequence Detail 19151 C57BL/6J ±  kb
transcript OTTMUST00000089523 VEGA | MGI Sequence Detail 5102 Not Applicable  
polypeptide OTTMUSP00000048936 VEGA | MGI Sequence Detail 1300 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    60 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000009065 insulin receptor-related protein
  • EC
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR006211 Furin-like cysteine-rich domain
    IPR006212 Furin-like repeat
    IPR009030 Growth factor receptor cysteine-rich domain
    IPR013783 Immunoglobulin-like fold
    IPR028792 Insulin receptor-related protein
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR000494 Receptor L-domain
    IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
    IPR008266 Tyrosine-protein kinase, active site
    IPR020635 Tyrosine-protein kinase, catalytic domain
    IPR016246 Tyrosine-protein kinase, insulin-like receptor
    IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
Molecular
Reagents
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  • All nucleic 13
    cDNA 11
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:55017 Hirayama I, et al., Insulin receptor-related receptor is expressed in pancreatic beta-cells and stimulates tyrosine phosphorylation of insulin receptor substrate-1 and -2. Diabetes. 1999 Jun;48(6):1237-44
  • Latest
    J:194542 Ghai R, et al., Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E643-52

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory