About   Help   FAQ
Insrr Gene Detail
Summary
  • Symbol
    Insrr
  • Name
    insulin receptor-related receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346037
    NCBI Gene: 23920
  • Gene Overview
    MyGene.info: INSRR
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:87796951-87816101 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 38.70 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    60 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346037
protein coding gene Chr3:87796908-87816101 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027369
protein coding gene Chr3:87920812-87942074 (+)
A/J MGP_AJ_G0027333
protein coding gene Chr3:84937753-84956896 (+)
AKR/J MGP_AKRJ_G0027299
protein coding gene Chr3:86991839-87015747 (+)
BALB/cJ MGP_BALBcJ_G0027342
protein coding gene Chr3:85033940-85053071 (+)
C3H/HeJ MGP_C3HHeJ_G0027085
protein coding gene Chr3:87288709-87308811 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027788
protein coding gene Chr3:91147173-91168425 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025141
protein coding gene Chr3:80557771-80578115 (+)
CAST/EiJ MGP_CASTEiJ_G0026532
protein coding gene Chr3:87507381-87526539 (+)
CBA/J MGP_CBAJ_G0027060
protein coding gene Chr3:94232291-94253762 (+)
DBA/2J MGP_DBA2J_G0027196
protein coding gene Chr3:84421473-84440841 (+)
FVB/NJ MGP_FVBNJ_G0027165
protein coding gene Chr3:82701183-82721424 (+)
LP/J MGP_LPJ_G0027304
protein coding gene Chr3:88882953-88903472 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027184
protein coding gene Chr3:100496778-100517274 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027846
protein coding gene Chr3:86768640-86787749 (+)
PWK/PhJ MGP_PWKPhJ_G0026265
protein coding gene Chr3:84225365-84244584 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026082
protein coding gene Chr3:85956367-85980758 (+)
WSB/EiJ MGP_WSBEiJ_G0026611
protein coding gene Chr3:87130797-87152582 (+)



Homology
more
  • Human Ortholog
    INSRR, insulin receptor related receptor
  • Vertebrate Orthologs
    8
  • Human Ortholog
    INSRR, insulin receptor related receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IRR
  • Links
    NCBI Gene ID: 3645
    neXtProt AC: NX_P14616
    UniProt: P14616

  • Chr Location
    1q23.1; chr1:156840873-156858920 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    8 phenotype references
Mice homozygous for a targeted null mutation exhibit no anomalies in pancreatic islet morphology, beta-cell mass or pancreatic secretory function. This mutation in combination with Insr mutant mice does not affect the diabetes predisposition of Insr mutant mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005640 Ensembl Gene Model | MGI Sequence Detail 19151 C57BL/6J ±  kb
transcript ENSMUST00000029711 Ensembl | MGI Sequence Detail 5102 Not Applicable  
polypeptide ENSMUSP00000029711 Ensembl | MGI Sequence Detail 1300 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 13
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 38
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 9
    Phenotypes 8
  • Earliest
    J:55017 Hirayama I, et al., Insulin receptor-related receptor is expressed in pancreatic beta-cells and stimulates tyrosine phosphorylation of insulin receptor substrate-1 and -2. Diabetes. 1999 Jun;48(6):1237-44
  • Latest
    J:243411 Rutledge EA, et al., Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development. Development. 2017 Sep 01;144(17):3177-3188

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/13/2018
MGI 6.13
The Jackson Laboratory