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Insrr
Gene Detail
Symbol

Name
ID
Insrr
insulin receptor-related receptor
MGI:1346037
Feature Type
protein coding gene
Genetic Map
Chromosome 3
38.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:87796951-87816101 bp, + strand
From VEGA annotation of GRCm38

  19151 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56539  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: INSRR
Protein SuperFamily: insulin receptor
Gene Tree: Insrr

Human
homologs
INSRR, insulin receptor-related receptor
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3645
neXtProt AC: NX_P14616

Human Synonyms: IRR

Human Chr (Location): 1q21-q23; chr1:156840873-156858920 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a targeted null mutation exhibit no anomalies in pancreatic islet morphology, beta-cell mass or pancreatic secretory function. This mutation in combination with Insr mutant mice does not affect the diabetes predisposition of Insr mutant mice.
 
Interactions
Insrr interacts with 135 markers (Mir15a, Mir17, Mir18, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (46)    Tissues (11)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 40
RT-PCR 6
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase insrr    NEW 
Molecular
reagents
All nucleic(13) cDNA(11) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000035156 (Evidence)
Ensembl Gene Model ENSMUSG00000005640 (Evidence)
Entrez Gene 23920 (Evidence)
UniGene 42041
DFCI TC1596901, TC1588340
DoTS DT.91570846, DT.40143220
NIA Mouse Gene Index U003410
EC 2.7.10.1
Consensus CDS Project CCDS17454.1
International Mouse Phenotyping Consortium Status Insrr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035156 VEGA Gene Model | MGI Sequence Detail 19151 C57BL/6J ±  kb
transcript OTTMUST00000089523 VEGA | MGI Sequence Detail 5102 Not Applicable 
polypeptide OTTMUSP00000048936 VEGA | MGI Sequence Detail 1300 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(10) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(60 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000494 EGF receptor, L domain
InterPro IPR003961 Fibronectin, type III
InterPro IPR006211 Furin-like cysteine-rich domain
InterPro IPR006212 Furin-like repeat
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016246 Tyrosine-protein kinase, insulin-like receptor
InterPro IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
Protein Ontology PR:000009065 insulin receptor-related protein
References
(Earliest) J:55017 Hirayama I, et al., Insulin receptor-related receptor is expressed in pancreatic beta-cells and stimulates tyrosine phosphorylation of insulin receptor substrate-1 and -2. Diabetes. 1999 Jun;48(6):1237-44
(Latest) J:194542 Ghai R, et al., Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E643-52
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory