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Tshz1 Gene Detail
Summary
  • Symbol
    Tshz1
  • Name
    teashirt zinc finger family member 1
  • Synonyms
    5730407I04Rik, D18Bwg1409e, Mtsh1, NY-CO-33, Sdccag33, teashirt1, Tsh1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346031
    NCBI Gene: 110796
  • Gene Overview
    MyGene.info: TSHZ1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:84011627-84086404 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 57.53 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    459 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346031
protein coding gene Chr18:84011627-84086562 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024604
protein coding gene Chr18:85146075-85223953 (-)
A/J MGP_AJ_G0024571
protein coding gene Chr18:81398545-81473516 (-)
AKR/J MGP_AKRJ_G0024542
protein coding gene Chr18:83821097-83895543 (-)
BALB/cJ MGP_BALBcJ_G0024569
protein coding gene Chr18:81588568-81664254 (-)
C3H/HeJ MGP_C3HHeJ_G0024338
protein coding gene Chr18:83943920-84018777 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025016
protein coding gene Chr18:87261623-87341128 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022447
protein coding gene Chr18:80108487-80183674 (-)
CAST/EiJ MGP_CASTEiJ_G0023811
protein coding gene Chr18:84273920-84354252 (-)
CBA/J MGP_CBAJ_G0024308
protein coding gene Chr18:90402948-90478173 (-)
DBA/2J MGP_DBA2J_G0024438
protein coding gene Chr18:80919307-80993777 (-)
FVB/NJ MGP_FVBNJ_G0024404
protein coding gene Chr18:80241959-80319149 (-)
LP/J MGP_LPJ_G0024522
protein coding gene Chr18:84942063-85024135 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024434
protein coding gene Chr18:91632882-91711426 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025065
protein coding gene Chr18:84015793-84091954 (-)
PWK/PhJ MGP_PWKPhJ_G0023556
protein coding gene Chr18:81307188-81384304 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023362
protein coding gene Chr18:84055058-84139721 (-)
WSB/EiJ MGP_WSBEiJ_G0023873
protein coding gene Chr18:83979419-84056827 (-)



Homology
more
  • Human Ortholog
    TSHZ1, teashirt zinc finger homeobox 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TSHZ1, teashirt zinc finger homeobox 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAA, NY-CO-33, SDCCAG33, TSH1
  • Links
    NCBI Gene ID: 10194
    neXtProt AC: NX_Q6ZSZ6
    UniProt: Q6ZSZ6

  • Chr Location
    18q22.3; chr18:75210755-75289950 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4227
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TSHZ1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 3 alleles in 4 genetic backgrounds
    8 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die shortly after birth of respiratory distress, have defects in soft palate formation, have altered axial skeleton and have middle ear defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046982 Ensembl Gene Model | MGI Sequence Detail 74778 C57BL/6J ±  kb
    transcript ENSMUST00000060303 Ensembl | MGI Sequence Detail 5656 Not Applicable  
    polypeptide ENSMUSP00000089388 Ensembl | MGI Sequence Detail 1084 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 85
      cDNA 83
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-33960, MGI:106268, MGI:1917748
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 27
      Gene Ontology 6
      Phenotypes 6
    • Earliest
      J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
    • Latest
      J:264268 Li J, et al., Transcription Factors Sp8 and Sp9 Coordinately Regulate Olfactory Bulb Interneuron Development. Cereb Cortex. 2018 Sep 1;28(9):3278-3294

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory