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Mab21l2
Gene Detail
Symbol

Name
ID
Mab21l2
mab-21-like 2 (C. elegans)
MGI:1346022
Feature Type
protein coding gene
Genetic Map
Chromosome 3
37.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:86546050-86548629 bp, - strand
From VEGA annotation of GRCm38

  2580 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7824  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MAB21L2
Gene Tree: Mab21l2

Human
homologs
MAB21L2, mab-21-like 2 (C. elegans)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10586
neXtProt AC: NX_Q9Y586

Human Synonyms: MCOPS14

Human Chr (Location): 4q31; chr4:150581925-150584693 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MAB21L2

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix )
 
Homozygous mutation of this gene results in omphalocele and defects in ventral body wall formation resulting in death at mid-gestation. Mutants have impaired development of the retina and lens.
 
Interactions
Mab21l2 interacts with 223 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process camera-type eye development, embryonic body morphogenesis, ...
Component nucleus
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (143)    Tissues (111)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 143
cDNA source data(40)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mab21l2 ; ZFIN mab21l2    NEW 
Molecular
reagents
All nucleic(44) Genomic(1) cDNA(42) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000051680 (Evidence)
Ensembl Gene Model ENSMUSG00000057777 (Evidence)
Entrez Gene 23937 (Evidence)
UniGene 389466
DFCI TC1580671
DoTS DT.483528
Consensus CDS Project CCDS17447.1
International Mouse Phenotyping Consortium Status Mab21l2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051680 VEGA Gene Model | MGI Sequence Detail 2580 C57BL/6J ±  kb
transcript OTTMUST00000130360 VEGA | MGI Sequence Detail 2580 Not Applicable 
polypeptide Q8BPP1 UniProt | EBI | MGI Sequence Detail 359 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(16 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024810 Mab-21 domain
InterPro IPR020950 Protein male abnormal 21-related
InterPro IPR000772 Ricin B lectin domain
Protein Ontology PR:000010035 protein mab-21-like 2
Graphical View of Protein Domain Structure
References
(Earliest) J:57575 Wong RL, et al., Genomic cloning and chromosomal localization of the mouse Mab21l2 locus. Cytogenet Cell Genet. 1999;86(1):21-4
(Latest) J:201042 Saito Y, et al., The septum transversum mesenchyme induces gall bladder development. Biol Open. 2013;2:779-788
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory