Mab21l2
Gene Detail

Symbol Name ID

Mab21l2 mab-21-like 2 (C. elegans) MGI:1346022

Feature Type

protein coding gene

Genetic Map

Chromosome 3

37.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr3:86545581-86548283 bp, - strand From NCBI annotation of GRCm38   2703 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7824  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Mab21l2

Human homologs

Human Homolog		MAB21L2, mab-21-like 2 (C. elegans)
NCBI Gene ID		10586
neXtProt AC		NX_Q9Y586
Human Chr (Location)		4q31; chr4:151503077-151505845 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Homozygous mutation of this gene results in omphalocele and defects in ventral body wall formation resulting in death at mid-gestation. Mutants have impaired development of the retina and lens.

 

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Process	camera-type eye development, embryonic body morphogenesis, ...
Component	nucleus

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (143)    Tissues (111)    Images (22)
Theiler Stages: 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24

Assay Type	Results
RNA in situ	143

cDNA source data(40)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(44) Genomic(1) cDNA(42) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000057777 (Evidence)
Entrez Gene	23937 (Evidence)
UniGene	389466
DFCI	TC1580671
DoTS	DT.483528
Consensus CDS Project	CCDS17447.1
International Mouse Knockout Project Status	Mab21l2

Sequences

Length	Strain/Species
genomic	23937	NCBI Gene Model | MGI Sequence Detail	2703	C57BL/6J
transcript	NM_011839	RefSeq | MGI Sequence Detail	2703	C57BL/6
polypeptide	Q8BPP1	UniProt | EBI | MGI Sequence Detail	359	Not Applicable

All sequences(18) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(10 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR024810	Mab-21 domain
InterPro	IPR024801	Mab-21-like 1
InterPro	IPR020950	Protein male abnormal 21-related
InterPro	IPR000772	Ricin B lectin domain
Protein Ontology	PR:000010035	protein mab-21-like 2

Graphical View of Protein Domain Structure

References

(Earliest) J:57575 Wong RL, et al., Genomic cloning and chromosomal localization of the mouse Mab21l2 locus. Cytogenet Cell Genet. 1999;86(1):21-4
(Latest) J:186931 Saito Y, et al., Mab21l2 is essential for embryonic heart and liver development. PLoS One. 2012;7(3):e32991
All references(29)