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Mab21l2 Gene Detail
Summary
  • Symbol
    Mab21l2
  • Name
    mab-21-like 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346022
    NCBI Gene: 23937
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:86453357-86455590 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 3, 37.86 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    15 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346022
protein coding gene Chr3:86452888-86455590 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027355
protein coding gene Chr3:86601678-86604910 (-)
A/J MGP_AJ_G0027319
protein coding gene Chr3:83653822-83656873 (-)
AKR/J MGP_AKRJ_G0027285
protein coding gene Chr3:85670864-85673912 (-)
BALB/cJ MGP_BALBcJ_G0027328
protein coding gene Chr3:83746726-83749774 (-)
C3H/HeJ MGP_C3HHeJ_G0027072
protein coding gene Chr3:85960859-85964822 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027774
protein coding gene Chr3:89801451-89805449 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025127
protein coding gene Chr3:79295623-79298672 (-)
CAST/EiJ MGP_CASTEiJ_G0026519
protein coding gene Chr3:86183194-86186158 (-)
CBA/J MGP_CBAJ_G0027047
protein coding gene Chr3:92808050-92810881 (-)
DBA/2J MGP_DBA2J_G0027183
protein coding gene Chr3:83160647-83163736 (-)
FVB/NJ MGP_FVBNJ_G0027151
protein coding gene Chr3:81465670-81468707 (-)
LP/J MGP_LPJ_G0027291
protein coding gene Chr3:87529812-87532610 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027170
protein coding gene Chr3:99111315-99114185 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027832
protein coding gene Chr3:85443466-85446514 (-)
PWK/PhJ MGP_PWKPhJ_G0026253
protein coding gene Chr3:82953615-82956477 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026069
protein coding gene Chr3:84629375-84632427 (-)
WSB/EiJ MGP_WSBEiJ_G0026597
protein coding gene Chr3:85826261-85829076 (-)



Homology
more
  • Human Ortholog
    MAB21L2, mab-21 like 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAB21L2, mab-21 like 2
  • Synonyms
    MCOPS14, MCSKS14
  • Links
    NCBI Gene ID: 10586
    neXtProt AC: NX_Q9Y586
    UniProt: Q9Y586

  • Chr Location
    4q31.3; chr4:150582151-150584693 (+)  GRCh38

Human Diseases
more
  • Diseases
    2 with human MAB21L2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in omphalocele and defects in ventral body wall formation resulting in death at mid-gestation. Mutants have impaired development of the retina and lens.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23937 NCBI Gene Model | MGI Sequence Detail 2234 C57BL/6J ±  kb
    transcript NM_011839 RefSeq | MGI Sequence Detail 2252 C57BL/6  
    polypeptide Q8BPP1 UniProt | EBI | MGI Sequence Detail 359 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      Genomic 1
      cDNA 45
      Other 5

      Microarray probesets 3
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 18
      Diseases 1
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:57575 Wong RL, et al., Genomic cloning and chromosomal localization of the mouse Mab21l2 locus. Cytogenet Cell Genet. 1999;86(1):21-4
    • Latest
      J:327588 Yamada R, et al., Single-cell transcriptional analysis reveals developmental stage-dependent changes in retinal progenitors in the murine early optic vesicle. Biochem Biophys Res Commun. 2021 Mar 5;543:80-86

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory