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Slco2a1 Gene Detail
Summary
  • Symbol
    Slco2a1
  • Name
    solute carrier organic anion transporter family, member 2a1
  • Synonyms
    2310021C19Rik, mPgt, Pgt, Slc21a2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346021
    NCBI Gene: 24059
  • Gene Overview
    MyGene.info: SLCO2A1
Location & Maps
more
  • Sequence Map
    Chr9:102988712-103096002 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      107291 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 54.72 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    SLCO2A1, solute carrier organic anion transporter family member 2A1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLCO2A1, solute carrier organic anion transporter family member 2A1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MATR1, OATP2A1, PGT, PHOAR2, SLC21A2
  • Links
    NCBI Gene ID: 6578
    neXtProt AC: NX_Q92959

  • Chr Location
    3q21; chr3:133932696-134030076 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SLCO2A1 associations

Human Disease Mouse Models
       Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 2; PHOAR2   OMIM: 614441
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    48
  • Gene trapped
    45
  • Targeted
    3
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit preinatel or early psotnatal lethality due to a patent ductus arteriosus and abnormal protaglandin metabolism.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048443 VEGA Gene Model | MGI Sequence Detail 107291 C57BL/6J ±  kb
transcript OTTMUST00000124161 VEGA | MGI Sequence Detail 7122 Not Applicable  
polypeptide OTTMUSP00000067602 VEGA | MGI Sequence Detail 643 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    629 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000015226 solute carrier organic anion transporter family member 2A1
  • InterPro Domains
    IPR002350 Kazal domain
    IPR020846 Major facilitator superfamily domain
    IPR004156 Organic anion transporter polypeptide OATP
Molecular
Reagents
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  • All nucleic 17
    cDNA 15
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
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MGI:1915306
References
more
  • Summaries
    All 39
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:57568 Pucci ML, et al., Cloning of mouse prostaglandin transporter PGT cDNA: species-specific substrate affinities. Am J Physiol. 1999 Sep;277(3 Pt 2):R734-41
  • Latest
    J:233880 Chi Y, et al., Inhibition of the Prostaglandin Transporter PGT Lowers Blood Pressure in Hypertensive Rats and Mice. PLoS One. 2015;10(6):e0131735

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory