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Slco2a1
Gene Detail
 Symbol
Name
ID
Slco2a1
solute carrier organic anion transporter family, member 2a1
MGI:1346021
Synonyms 2310021C19Rik, mPgt, Pgt, Slc21a2
Feature Type protein coding gene
Genetic Map
Chromosome 9
54.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:103008489-103087849 bp, + strand
From NCBI annotation of GRCm38

  79361 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38077  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Slco2a1

Human
homologs
Human Homolog SLCO2A1, solute carrier organic anion transporter family, member 2A1
NCBI Gene ID 6578
neXtProt AC  NX_Q92959
Human Synonyms  MATR1, OATP2A1, PGT, PHOAR2, SLC21A2
Human Chr (Location)  3q21; chr3:133932696-134030076 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SLCO2A1
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit preinatel or early psotnatal lethality due to a patent ductus arteriosus and abnormal protaglandin metabolism.
 
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process ion transmembrane transport, prostaglandin transport, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function prostaglandin transmembrane transporter activity, transporter activity
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (172)    Tissues (172)    Images (8)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 172
cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(17) cDNA(15) Primer pair(2)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000032548 (Evidence)
Entrez Gene24059 (Evidence)
DFCITC1578147, TC1582531, TC1597516, TC1612133, TC1688002
DoTSDT.101387992, DT.101387996, DT.536773, DT.87064584, DT.94363138, DT.97406785
NIA Mouse Gene IndexU010940, U172588
Consensus CDS ProjectCCDS23448.1
International Mouse Knockout Project StatusSlco2a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 24059 NCBI Gene Model | MGI Sequence Detail 79361 C57BL/6J ±  kb
transcript NM_033314 RefSeq | MGI Sequence Detail 4033 C57BL/6 
polypeptide Q9EPT5 UniProt | EBI | MGI Sequence Detail 643 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(4) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(529 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002350 Kazal domain
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR016196 Major facilitator superfamily domain, general substrate transporter
InterPro IPR004156 Organic anion transporter polypeptide OATP
Protein Ontology PR:000015226 solute carrier organic anion transporter family member 2A1
Graphical View of Protein Domain Structure
References (Earliest) J:57568 Pucci ML, et al., Cloning of mouse prostaglandin transporter PGT cDNA: species-specific substrate affinities. Am J Physiol. 1999 Sep;277(3 Pt 2):R734-41
(Latest) J:185546 Syeda MM, et al., Prostaglandin transporter modulates wound healing in diabetes by regulating prostaglandin-induced angiogenesis. Am J Pathol. 2012 Jul;181(1):334-46
All references(35)
Other
accession IDs
MGI:1915306

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory