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Vax2 Gene Detail
Summary
  • Symbol
    Vax2
  • Name
    ventral anterior homeobox 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346018
    NCBI Gene: 24113
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:83711264-83738304 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 35.94 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    80 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346018
protein coding gene Chr6:83711264-83738313 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030937
protein coding gene Chr6:84736994-84766830 (+)
A/J MGP_AJ_G0030906
protein coding gene Chr6:81516708-81543688 (+)
AKR/J MGP_AKRJ_G0030834
protein coding gene Chr6:83874029-83900848 (+)
BALB/cJ MGP_BALBcJ_G0030916
protein coding gene Chr6:81538979-81566131 (+)
C3H/HeJ MGP_C3HHeJ_G0030794
protein coding gene Chr6:100503789-100530602 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031376
protein coding gene Chr6:87082364-87112979 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028562
protein coding gene Chr6:79877876-79906003 (+)
CAST/EiJ MGP_CASTEiJ_G0030025
protein coding gene Chr6:83897040-83926930 (+)
CBA/J MGP_CBAJ_G0030603
protein coding gene Chr6:90510127-90537052 (+)
DBA/2J MGP_DBA2J_G0030756
protein coding gene Chr6:80828342-80855361 (+)
FVB/NJ MGP_FVBNJ_G0030709
protein coding gene Chr6:80040818-80068217 (+)
LP/J MGP_LPJ_G0030835
protein coding gene Chr6:84741483-84770115 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030745
protein coding gene Chr6:94774251-94802630 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031400
protein coding gene Chr6:83706649-83734456 (+)
PWK/PhJ MGP_PWKPhJ_G0029740
protein coding gene Chr6:79745191-79773102 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029568
protein coding gene Chr6:82526251-82554932 (+)
WSB/EiJ MGP_WSBEiJ_G0030106
protein coding gene Chr6:84119665-84148832 (+)



Homology
more
  • Human Ortholog
    VAX2, ventral anterior homeobox 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    VAX2, ventral anterior homeobox 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DRES93
  • Links
    NCBI Gene ID: 25806
    neXtProt AC: NX_Q9UIW0
    UniProt: Q9UIW0

  • Chr Location
    2p13.3; chr2:70900551-70933446 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8048
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: VAX2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants for one allele show incomplete closure of optic fissure leading to coloboma, the frequency of which is strongly influenced by genetic background. Homozygous null mutants for 2 different alleles have abnormal projections of ventralretinal ganglion cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 24113 NCBI Gene Model | MGI Sequence Detail 27041 C57BL/6J ±  kb
    transcript NM_011912 RefSeq | MGI Sequence Detail 1267 C57BL/6  
    polypeptide Q9WTP9 UniProt | EBI | MGI Sequence Detail 292 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 10
      Primer pair 3
      Other 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 49
      Gene Ontology 8
      Phenotypes 12
    • Earliest
      J:57663 Barbieri AM, et al., A homeobox gene, vax2, controls the patterning of the eye dorsoventral axis. Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10729-34
    • Latest
      J:249800 Burnett JB, et al., Proper ciliary assembly is critical for restricting Hedgehog signaling during early eye development in mice. Dev Biol. 2017 Oct 1;430(1):32-40

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    05/14/2019
    MGI 6.14
    The Jackson Laboratory