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Clpx Gene Detail
Summary
  • Symbol
    Clpx
  • Name
    caseinolytic mitochondrial matrix peptidase chaperone subunit
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346017
    NCBI Gene: 270166
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:65201542-65237940 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 35.22 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    189 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346017
protein coding gene Chr9:65201533-65237940 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034953
protein coding gene Chr9:65016878-65057739 (+)
A/J MGP_AJ_G0034933
protein coding gene Chr9:62830918-62866835 (+)
AKR/J MGP_AKRJ_G0034863
protein coding gene Chr9:64306208-64349551 (+)
BALB/cJ MGP_BALBcJ_G0034926
protein coding gene Chr9:62552338-62588915 (+)
C3H/HeJ MGP_C3HHeJ_G0034636
protein coding gene Chr9:64838264-64875509 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035445
protein coding gene Chr9:66789490-66827289 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032356
protein coding gene Chr9:62479685-62518254 (+)
CAST/EiJ MGP_CASTEiJ_G0033957
protein coding gene Chr9:65030489-65067827 (+)
CBA/J MGP_CBAJ_G0034607
protein coding gene Chr9:69116137-69156519 (+)
DBA/2J MGP_DBA2J_G0034766
protein coding gene Chr9:62602144-62638109 (+)
FVB/NJ MGP_FVBNJ_G0034708
protein coding gene Chr9:61922876-61960128 (+)
LP/J MGP_LPJ_G0034849
protein coding gene Chr9:65296681-65332101 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034750
protein coding gene Chr9:70356746-70395319 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035467
protein coding gene Chr9:64411992-64448678 (+)
PWK/PhJ MGP_PWKPhJ_G0033661
protein coding gene Chr9:62802054-62840356 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033495
protein coding gene Chr9:64700627-64738714 (+)
WSB/EiJ MGP_WSBEiJ_G0034070
protein coding gene Chr9:64312155-64348868 (+)



Homology
more
  • Human Ortholog
    CLPX, caseinolytic mitochondrial matrix peptidase chaperone subunit X
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLPX, caseinolytic mitochondrial matrix peptidase chaperone subunit X
  • Synonyms
    EPP2
  • Links
    NCBI Gene ID: 10845
    neXtProt AC: NX_O76031
    UniProt: O76031

  • Chr Location
    15q22.31; chr15:65148219-65185342 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human CLPX associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete lethality prior to organogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015357 Ensembl Gene Model | MGI Sequence Detail 36399 C57BL/6J ±  kb
    transcript ENSMUST00000015501 Ensembl | MGI Sequence Detail 2885 Not Applicable  
    polypeptide ENSMUSP00000015501 Ensembl | MGI Sequence Detail 634 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 76
      cDNA 73
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2143186
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:55436 Santagata S, et al., Molecular cloning and characterization of a mouse homolog of bacterial ClpX, a novel mammalian class II member of the Hsp100/Clp chaperone family. J Biol Chem. 1999 Jun 4;274(23):16311-9
    • Latest
      J:341934 Guo C, et al., ClpP/ClpX deficiency impairs mitochondrial functions and mTORC1 signaling during spermatogenesis. Commun Biol. 2023 Oct 5;6(1):1012

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory