Clpx MGI Mouse Gene Detail - MGI:1346017 - caseinolytic mitochondrial matrix peptidase chaperone subunit

Symbol

Clpx
Name

caseinolytic mitochondrial matrix peptidase chaperone subunit

Feature Type

protein coding gene
IDs

MGI:1346017
NCBI Gene: 270166
Alliance

genome feature page
Transcription Start Sites

9 TSS

Sequence Map

Chr9:65201542-65237940 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 35.22 cM
Mapping Data

3 experiments

SNPs within 2kb

823 from dbSNP Build 142
Strain Annotations

19
PCR

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346017	protein coding gene	Chr9:65201533-65237940 (+)
129S1/SvImJ	ENSMUSG00200041253	protein coding gene	Chr9:62304820-62339777 (+)
A/J	ENSMUSG00195023925	protein coding gene	Chr9:62029278-62065170 (+)
AKR/J	ENSMUSG00220040502	protein coding gene	Chr9:62164574-62203572 (+)
BALB/cJ	ENSMUSG00180014789	protein coding gene	Chr9:62152792-62191800 (+)
C3H/HeJ	ENSMUSG00175012257	protein coding gene	Chr9:62162974-62198860 (+)
C57BL/6NJ	ENSMUSG00215017914	protein coding gene	Chr9:62139830-62178831 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032356	protein coding gene	Chr9:62479685-62518254 (+)
CAST/EiJ	ENSTCUG00005028418	protein coding gene	Chr9:62053859-62091156 (+)
CBA/J	ENSMUSG00210013834	protein coding gene	Chr9:62235816-62276123 (+)
DBA/2J	ENSMUSG00185031076	protein coding gene	Chr9:62265835-62301763 (+)
FVB/NJ	ENSMUSG00205020858	protein coding gene	Chr9:62589967-62627374 (+)
JF1/MsJ	ENSUMUG00000025348	protein coding gene	Chr9:62326980-62364259 (+)
LP/J	ENSMUSG00230025152	protein coding gene	Chr9:62503843-62538795 (+)
NOD/ShiLtJ	ENSMUSG00190019247	protein coding gene	Chr9:62357336-62393223 (+)
NZO/HlLtJ	ENSMUSG00225043934	protein coding gene	Chr9:62572321-62608295 (+)
PWK/PhJ	ENSLUMG00010024546	protein coding gene	Chr9:62288045-62325546 (+)
SPRET/EiJ	ENSMSPG00010018393	protein coding gene	Chr9:63342330-63379629 (+)
WSB/EiJ	ENSIUOG00005024822	protein coding gene	Chr9:61748636-61784622 (+)

Human Ortholog

CLPX, caseinolytic mitochondrial matrix peptidase chaperone subunit X

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CLPX, caseinolytic mitochondrial matrix peptidase chaperone subunit X
Synonyms

EPP2
Links

HGNC:2088

NCBI Gene ID: 10845

UniProt: O76031
Chr Location

15q22.31; chr15:65148219-65185393 (-) GRCh38

MGI Vertebrate Homology

Clpx stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CLPX
Gene Tree

Clpx

Diseases

1 with human CLPX associations

				Human Disease	Mouse Models
				erythropoietic protoporphyria IDs erythropoietic protoporphyria DOID:13270 ICD10CM:E80.0 MESH:D046351 NCI:C84698 OMIM:177000 OMIM:300752 ORDO:79278 UMLS_CUI:C0162568

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

10 phenotypes from 1 allele in 2 genetic backgrounds
1 images
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

2
Targeted

2
Genomic Mutations

1 involving Clpx
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete lethality prior to organogenesis.

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All GO Annotations

37
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

667
Tissues

60
cDNA Data

73
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase clpx

ZFIN clpxa, clpxb

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All Sequences

58
RefSeq

6
UniProt

7
CCDS

CCDS23288.1, CCDS40669.1

Ensembl

ENSMUSG00000015357 (Evidence)
NCBI Gene

270166

			Length	Strain/Species	Flank
genomic	ENSMUSG00000015357	Ensembl Gene Model \| MGI Sequence Detail	36399	C57BL/6J	± kb
transcript	ENSMUST00000015501	Ensembl \| MGI Sequence Detail	2885	Not Applicable
polypeptide	ENSMUSP00000015501	Ensembl \| MGI Sequence Detail	634	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000005604 ATP-dependent clpX-like chaperone, mitochondrial

(term hierarchy)
EC

3.6.4.10
InterPro Domains

IPR003593 AAA+ ATPase domain

IPR003959 ATPase, AAA-type, core

IPR050052 ATP-dependent Clp protease ATP-binding subunit ClpX

IPR059067 ATP-dependent ClpX-like chaperone, zinc ribbon domain

IPR019489 Clp ATPase, C-terminal

IPR004487 Clp protease, ATP-binding subunit ClpX

IPR059188 ClpX-like, zinc ribbon domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase
GlyGen

Q9JHS4 1 site, 1 O-linked glycan (1 site)

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All nucleic 76

cDNA 73

Primer pair 3

Microarray probesets 5

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MGI:2143186

Summaries

All 51

Developmental Gene Expression 2

Gene Ontology 11

Phenotypes 14
Earliest

J:55436 Santagata S, et al., Molecular cloning and characterization of a mouse homolog of bacterial ClpX, a novel mammalian class II member of the Hsp100/Clp chaperone family. J Biol Chem. 1999 Jun 4;274(23):16311-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Clpx:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr85679	Chr9:65201439-65201451 (+)	-97 bp
Tssr85680	Chr9:65201461-65201486 (+)	-68 bp
Tssr85681	Chr9:65201557-65201623 (+)	48 bp
Tssr85682	Chr9:65201652-65201657 (+)	113 bp
Tssr85683	Chr9:65201677-65201699 (+)	146 bp
Tssr85684	Chr9:65201709-65201719 (+)	172 bp
Tssr85685	Chr9:65201722-65201726 (+)	182 bp
Tssr85686	Chr9:65201839-65201858 (+)	307 bp
Tssr85687	Chr9:65220096-65220117 (+)	18,565 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24