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Clpx Gene Detail
Summary
  • Symbol
    Clpx
  • Name
    caseinolytic mitochondrial matrix peptidase chaperone subunit
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346017
    NCBI Gene: 270166
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:65294260-65330658 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 35.22 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    189 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346017
protein coding gene Chr9:65294250-65330658 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034953
protein coding gene Chr9:65016878-65057739 (+)
A/J MGP_AJ_G0034933
protein coding gene Chr9:62830918-62866835 (+)
AKR/J MGP_AKRJ_G0034863
protein coding gene Chr9:64306208-64349551 (+)
BALB/cJ MGP_BALBcJ_G0034926
protein coding gene Chr9:62552338-62588915 (+)
C3H/HeJ MGP_C3HHeJ_G0034636
protein coding gene Chr9:64838264-64875509 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035445
protein coding gene Chr9:66789490-66827289 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032356
protein coding gene Chr9:62479685-62518254 (+)
CAST/EiJ MGP_CASTEiJ_G0033957
protein coding gene Chr9:65030489-65067827 (+)
CBA/J MGP_CBAJ_G0034607
protein coding gene Chr9:69116137-69156519 (+)
DBA/2J MGP_DBA2J_G0034766
protein coding gene Chr9:62602144-62638109 (+)
FVB/NJ MGP_FVBNJ_G0034708
protein coding gene Chr9:61922876-61960128 (+)
LP/J MGP_LPJ_G0034849
protein coding gene Chr9:65296681-65332101 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034750
protein coding gene Chr9:70356746-70395319 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035467
protein coding gene Chr9:64411992-64448678 (+)
PWK/PhJ MGP_PWKPhJ_G0033661
protein coding gene Chr9:62802054-62840356 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033495
protein coding gene Chr9:64700627-64738714 (+)
WSB/EiJ MGP_WSBEiJ_G0034070
protein coding gene Chr9:64312155-64348868 (+)



Homology
more
  • Human Ortholog
    CLPX, caseinolytic mitochondrial matrix peptidase chaperone subunit
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CLPX, caseinolytic mitochondrial matrix peptidase chaperone subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EPP2
  • Links
    NCBI Gene ID: 10845
    neXtProt AC: NX_O76031
    UniProt: O76031

  • Chr Location
    15q22.31; chr15:65148219-65185420 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000015357 Ensembl Gene Model | MGI Sequence Detail 36399 C57BL/6J ±  kb
transcript ENSMUST00000015501 Ensembl | MGI Sequence Detail 2885 Not Applicable  
polypeptide ENSMUSP00000015501 Ensembl | MGI Sequence Detail 634 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 75
    cDNA 73
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGI:2143186
References
more
  • Summaries
    All 38
    Gene Ontology 9
    Phenotypes 7
  • Earliest
    J:55436 Santagata S, et al., Molecular cloning and characterization of a mouse homolog of bacterial ClpX, a novel mammalian class II member of the Hsp100/Clp chaperone family. J Biol Chem. 1999 Jun 4;274(23):16311-9
  • Latest
    J:231201 Al-Furoukh N, et al., ClpX stimulates the mitochondrial unfolded protein response (UPRmt) in mammalian cells. Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2580-91

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory